Mouse caudal vein injection fixing device and application method thereof

Abstract

The invention discloses a mouse caudal vein injection fixing device and an application method thereof. The mouse caudal vein injection fixing device comprises a base, a connecting plate, a fixed cylinder and a telescopic rod, wherein a first bearing seat and a second bearing seat are arranged on the base; the first bearing seat is hinged with the lower end of the connecting plate; a mounting plateis hinged at the upper end of the connecting plate; the fixed cylinder is hinged with a third bearing seat located on the mounting plate through a connecting piece; a fourth bearing seat is arrangedon the lower end surface of the mounting plate; two ends of the telescopic rod are hinged with the fourth bearing seat and the second bearing seat respectively; a tail blocking piece with a notch is hinged with an opening of the cylinder body of the fixed cylinder; a head blocking piece is arranged in the cylinder cavity of the cylinder body of the fixed cylinder and driven by a driving unit to slide; an annular air bag is arranged in the cylinder cavity of the cylinder body of the fixed cylinder and communicates with a pressure adjusting unit; and a tail placing block is slidably connected with and arranged in the sliding groove of the mounting plate. The objective of the invention is to provide the mouse caudal vein injection fixing device which is more convenient to operate, more flexible to adjust and better in adaptability to the body type of a mouse.

Description

technical field [0001] The invention relates to the technical field of animal experiments, in particular to a tail vein injection fixation device for mice and a use method thereof. Background technique [0002] Tail vein injection of mice is commonly used in drug screening and acute toxicity tests. Traditional mouse tail vein injection fixators are mostly cylindrical with an opening at one end that can be closed and the other end can be ventilated. When injecting, put the mouse into the cylinder, close one end of the cylinder, and expose the tail of the mouse through the opening at the end for tail vein injection. There are also some improved models that can adjust the space of the fixed cylinder according to the length of the mouse. [0003] A mouse tail vein injection fixation device disclosed in a Chinese invention patent application with the application publication number CN102451046A comprises a fixation plate and a fixation chamber fixed on the fixation plate, wherein...

AI Technical Summary

Problems solved by technology

[0005] 1. It is troublesome to use. The experimenter must first open the clamping part, unscrew the nut, remove the movable part, pull the mouse upside down into the fixed chamber, install the movable part, tighten the nut, and then close the clamping part. The operation is cumbersome ,Time-consuming;

[0006] 2. The radial space of the fixation chamber cannot be adjusted according to the size of the mice, resulting in a poor fixation effect on the mice. During the injection operation, because the mice are struggling violently, the operation of the intravenous injection becomes more difficult. Inexperience is prone to misoperation, and it is easy to cause accidents of stabbing experimenters

[0007] 3. Its angle cannot be adjusted and lacks flexibility

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