System and method for producing 90Y based on electron accelerator and 89Y2O3

Abstract

The invention discloses a system and method for producing 90Y based on an electron accelerator and 89Y2O3. The system comprises an electron generation section, an electron acceleration section, an electron-photon conversion part, a photon-neutron conversion part, a neutron shaping and moderating part, a target irradiation part, a first cooling part, a second cooling part, a third cooling part anda collection part. The invention provides a novel 90Y production mode based on an electron accelerator, the defects of the existing production mode are avoided, and the portability and safety of 90Y production are improved.

Description

technical field [0001] The invention belongs to the application field of nuclear technology, in particular to an electron accelerator-based 90 Y production system. Background technique [0002] 90 Y is an important medical radionuclide and has broad application prospects in radioimmunotherapy (RIT) of tumors. It has an appropriate physical half-life (T=64.0h), emits pure β ﹣ Particles; high β energy (maximum energy 2.3MeV, average energy 0.93MeV); average tissue range 2.5mm, maximum 11.9mm, calculated on the basis of a cell diameter of 20um, can kill cells within the range of 150-200 cell diameters, at 500 - 600 cell diameters have a killing effect and decay fonts 90 Zr is stable and non-toxic. [0003] 90 There are two production methods for Y: one is to use neutron irradiation in the reactor to irradiate high-purity 89 Y 2 o 3 target production 90 Y. Reactor Irradiation Production 90 Y is to use 89 Y(n,γ) 90 Y response, will 89 Y 2 o 3 The target is irradi...

AI Technical Summary

Problems solved by technology

from 90 Separation in Sr decay equilibrium system 90 The operation of Y is relatively simple, no neutron source is required, and it can be produced in a place far away from the reactor, and the resulting 90 The specific activity of Y is higher, but this method will inevitably bring a small amount of highly toxic 90 Defilement of Sr, causing harm to the human body

[0004] Patent CN108028086A proposes an electron accelerator-based 90 The Y production method is to bombard high atomic number substances with electron beams to generate photoneutrons, which further interact with natural zirconium or concentrated zirconium materials. 90 Y, pass 90 Zr(n,p) 90 Y response produces 90 Y, but in natural zirconium 90 The content of Zr is only 51.45%, and the direct bombardment of natural zirconium or concentrated zirconium materials with neutrons will cause 90 The yield of Y is not high, if 91 Extracting Zr will increase the cost and equipment complexity of production

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