Application of hyaluronic acid in influence of hemorheology
A technology of hyaluronic acid and blood rheology, applied in flow characteristics, scientific instruments, surface/boundary effects, etc., can solve problems such as resistance to clinical application of drag reducers, achieve inhibition of flow separation, reduce CFL thickness, increase blood The effect of perfusion
Pending Publication Date: 2020-05-12
HARBIN INST OF TECH
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- Abstract
- Description
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- Application Information
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Problems solved by technology
[0005] However, the current research on medical drag reducing agents is still limited to animal experiments, and the effectiveness of drag reducing agents can only be judged by the living conditions of animals
The basic issues related to the drag reduction of medical drag reducers have not been studied in detail, which has caused a major obstacle to the clinical application of drag reducers
Method used
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specific Embodiment approach 1
[0045] Specific Embodiment 1: This embodiment provides the application of hyaluronic acid in the effect on blood rheology.
specific Embodiment approach 2
[0046] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the influence on blood rheology is specifically that hyaluronic acid makes the shear viscosity of blood decrease with the increase of the shear rate. Others are the same as in the first embodiment.
specific Embodiment approach 3
[0047] Embodiment 3: This embodiment differs from Embodiment 1 in that: the effect on blood rheology is specifically that hyaluronic acid can increase blood flow velocity. Others are the same as in the first embodiment.
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Abstract
The invention discloses an application of hyaluronic acid in the influence of hemorheology, and relates to a new application of hyaluronic acid. The invention aims to provide a new application of hyaluronic acid so as to expand the application of the hyaluronic acid in treating some peripheral vascular diseases. The hyaluronic acid enables the shear viscosity of blood to decrease along with the increase of the shear rate of a wall surface; the flow velocity of the blood can be increased, the deformability and aggregation degree of red blood cells in the blood can be increased, the thickness ofCFL generated when the blood flows in a straight pipeline can be reduced, the thickness of CFL generated when the blood flows in a T-shaped pipeline can be reduced, and blood perfusion can be increased. The application is applied to the field of polymer drag reducers.
Description
technical field [0001] The invention relates to a new application of hyaluronic acid. Background technique [0002] When a certain water-soluble, long-chain polymer is added to the fluid, the resistance of the fluid flowing in the pipeline is significantly reduced, and the flow rate is significantly increased. The drag reduction phenomenon observed in the restricted flow of the pipeline is called the Toms phenomenon, and the polymer with the drag reduction effect is called the drag reducing polymer (DRP). Water-soluble, long-chain polymer drag reducer has the characteristics of trace amount and high efficiency. It only needs to add ppm level polymer drag reducer to the fluid to produce obvious drag reduction effect. [0003] In recent years, research on biocompatible drag reducing agents has gradually increased, and drag reducing agents have potential important value for patients suffering from ischemic diseases. When the blood circulation system is obstructed, it will lea...
Claims
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Login to View More IPC IPC(8): G01N11/00G01N13/04G01N15/00
CPCG01N11/00G01N13/04G01N15/00G01N15/01
Inventor 张科李冠颉时家奎赵九蓬李垚
Owner HARBIN INST OF TECH