32 results about "Peripheral Vascular Disorder" patented technology

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.

This invention relates to a method for prevention and treatment of Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, and age-related disorders including Osteoporosis, Arthritis, Type II Diabetes, Dementia and Alzheimer's disease in a subject comprising administering to said subject a therapeutically effective dosage of each component or combination of statins, bisphosphonates and/or cholesterol lowering agents or techniques, administered separately, in sequence or simultaneously. Cholesterol Metabolites (isoprenoids) are an integral component of the signaling pathway for Interleukin 6 mediated inflammation. Interleukin 6 inflammation is the common causative origin for Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, and age-related disorders including Osteoporosis, Arthritis, Type II Diabetes, Dementia and Alzheimer's disease. Said method for prevention and treatment of said disorders is based on inhibition of Interleukin-6 inflammation through regulation of cholesterol metabolism and isoprenoid depletion.

The present invention provides a portable device and method for enhancing blood flow in a limb and for reducing the risk of peripheral vascular disorders formation by applying periodic squeezing forces on a limb, in particular a lower limb. The device comprises an actuator and two rigid or semi-rigid flaps connected respectively to opposite sides of a housing such as to form an open closure around the limb. The housing contains machinery for actuating periodical change in the position of said flaps between contracted and relaxed positions.

Disclosed are single nucleotide polymorphisms (SNIps) associated with breast cancer, lung cancer, prostate cancer, non-insulin dependent diabetes, end stage renal disease due to non-insulin dependent diabetes, hypertension, end stage renal disease F due to hypertension, myocardial infarction, colon cancer, hypertension, atherosclerotic peripheral vascular disease due to hypertension, cerebrovascular accident due to hypertension, cataracts due to hypertension, cardiomyopathy with hypertension, myocardial infarction due to hypertension, non-insulin dependent diabetes mellitus, atherosclerotic peripheral vascular disease due to non-insulin dependent diabetes mellitus, cerebrovascular accident due to non-insulin dependent diabetes mellitus, ischemic cardiomyopathy, ischemic cardiomyopathy with non-insulin dependent diabetes mellitus, myocardial infarction due to non-insulin dependent diabetes mellitus, atrial fibrillations without valvular disease, alcohol abuse, anxiety, asthma, chronic obstructive pulmonary disease. cholecystectomy, degenerative joint disease, end stage renal disease and frequent de-clots, end stage renal disease due to focal segmental glomerular sclerosis, end stage renal disease due to insulin dependent diabetes mellitus, or seizure disorder. Also disclosed are methods for using SNPs to determine susceptibility to these diseases; nucleotide sequences containing SNPs; kits for determining the presence of SNPs; and methods of treatment or prophylaxis based on the presence of SNPs.

It is intended to provide a novel polypeptide having an activity of growing vascular endothelial cells, an activity of promoting transcription form c-fos promoter, an activity of promoting transciption from VEGF promoter and/or an angiogenic activity; a polynucleotide encoding this polypeptide; the above polypeptide and/or a pharmaceutical composition containing the polypeptide for treating a disease selected from the group consisting of obstructive arteriosclerosis, Buerger's disease, peripheral vascular disorder, angina, myocardial infraction, brain infarction, ischemic heart disease and ischemic brain disease; a method of treating these diseases; and an antibacterial composition. The above problems can be solved by isolating a novel peptide having the above-described activities and a nucleotide encoding this peptide.

The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain barrier functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides herein. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain barrier properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood-brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers.

The present invention provides methods for treating subjects having or at risk of having a neuropathological disorder or brain inflammatory diseases with and without vascular involvement, and systemic inflammatory vascular disease by administering a therapeutically effective amount of Activated Protein C (APC) to the subject. Brain disorders and brain inflammatory vascular diseases that can be treated by the invention method include all neurodegenerative diseases with different types of neuronal dysfunction, including stroke, Alzheimer's disease, Parkinson's disease, Huntington disease, neuroimmunological disorders such as multiple scelrosis and Gullian-Barre, encephalitis, meningitis, as well as other peripheral vascular diseases, such as diabetes, hypertension, artheriosclerosis. Also included are methods of treatment using APC in combination with a co-factor, such as Protein S.

Disclosed is a method for stimulating revascularization in a subject comprising the steps of:

• • (a) administering erythropoietin to the subject;
  • (b) collecting peripheral blood mononuclear cells from the subject; and
  • (c) administering the collected peripheral blood mononuclear cells to a target site of the subject. Peripheral blood mononuclear cells, and particularly CD34-positive cells, are mobilized into the peripheral blood of a subject by the administration of erythropoietin to the subject. The method of the present invention is useful for the treatment of ischemic diseases, such as peripheral vascular disorder.

The invention belongs to the technical field of medical instruments and particularly discloses a thermal image detection device for peripheral vascular diseases. The thermal image detection device for the peripheral vascular diseases comprises a computer, an operation table and a detection table, wherein the detection table is used for placement of a part to be detected of a person to be detected. A thermal infrared imager connected with the computer is installed on the operation table and is used for collecting infrared thermography image information of the person to be detected and transmitting the information to the computer for analysis and processing. A thermal image collecting and locating background device is arranged on the detection table. The detection device is fully combined with the infrared thermography technology, whether lesions exist in blood vessels of the person to be detected is judged through obtained infrared thermography distribution and temperature difference information for detecting the peripheral vascular diseases, and the detection device is quick in detection, free of wounds, easy to popularize, low in cost and suitable for early warning screening on the diseases for large-scale people; in addition, the detection device does not make contact with a human body in the process of detection, the detection process is free of wounds and pains and is in a non-contact mode, the detection device can be used for various simple and convenient stimulation detection methods and quick imaging, and the whole detection process is simple, quick and easy and convenient to operate.

The present invention is directed to a method for treating cardiovascular diseases such as acute myocardial infarction, atherosclerosis, heart failure, stroke, thrombosis, carditis (including acute myocarditis, acute pericarditis and complicated pericarditis), cardiac allograft rejection, cardiomyopathy, and peripheral vascular diseases. The method comprises administering to a subject in need thereof dapansutrile, in an effective amount. A preferred route of administration is oral administration.

The invention provides a traditional Chinese medicine composition for treating peripheral vascular diseases. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-10 parts of codonopsis pilosula, 2-5 parts of caulis spatholobi, 1-3 parts of rhizoma corydalis, 3-7 parts of radix bupleuri, 2-4 parts of blumea balsamifera, 5-15 parts of salvia miltiorrhiza, 10-20 parts of alangium platanifolium, 2-4 parts of alpine yarrow herb, 3-5 parts of lumbricus, 1-5 parts of ramuli euonymi and 1-3 parts of radix puerariae. The traditional Chinese medicine composition for treating the peripheral vascular diseases is prepared into a microsphere preparation, has a slow release effect, can play a long-acting treatment role, is wide in application range according to clinical verification, can be used for treating thromboangiitis obliterans, atherosclerosis obliterans, deep venous thrombosis of lower limbs, superficial thrombophlebitis, Raynaud's disease and the like, especially treating thromboangiitis obliterans, and has the advantages of quick response, good curative effect, convenience in use and the like.

The invention discloses a derivative of high veratryl alcohol and medical application of the derivative of high veratryl alcohol and belongs to the field of medicines. A compound with biological activity is a compound with a general formula (I), and salt, solvate or hydrate of the compound, wherein X1 is H or R4, X2 is H or R4, X3 is H or R4, but X1, X2 and X3 are not all H, and the X1, X2 and X3 can be R4 simultaneously; R4 is a group with a general formula (II), R5 is an alkyl group with 1 to 6 carbon atoms, or can be substituted by R6 optionally and contains a four to seven-membered ring of one or more of additional hetero atoms such as O, S(O)n and NR7; R7 is a C4-6 heterocyclic ring alkyl ring of one or more of hetero atoms such as O, NR8 and S(O)n; n is 0 to 2; and R8 is an alkyl group with 1 to 6 carbon atoms. The derivative of high veratryl alcohol is used for preparing medicines for treating or preventing cardiovascular disease, cerebrovascular disease and peripheral vascular disease, and medicines for preventing and delaying atherosis and relative diseases of atherosis, treating atherosis and relative diseases of atherosis, and delaying the progress of atherosis or preventing relapse of atherosis.

The invention discloses traditional Chinese medicine composition for preventing and treating arteriosclerosis. The composition is prepared from the following raw materials: 180 g of folium ginkgo, 180g of leech and 180 g of crab claw. The traditional Chinese medicine composition has the effects of promoting blood circulation and dredging the pulse, and is mainly used for treating symptoms such ashemiplegia, limb weakness or numbness and pain, dizziness and headache, chest distress and tingling, palpitation, limb cyanosis as well as blood stasis syndromes such as troke, coronary heart disease, peripheral vascular disease and diabetes complications. The composition is simple to prepare, convenient to take and free of toxic and side effects.

The invention discloses an application of hyaluronic acid in the influence of hemorheology, and relates to a new application of hyaluronic acid. The invention aims to provide a new application of hyaluronic acid so as to expand the application of the hyaluronic acid in treating some peripheral vascular diseases. The hyaluronic acid enables the shear viscosity of blood to decrease along with the increase of the shear rate of a wall surface; the flow velocity of the blood can be increased, the deformability and aggregation degree of red blood cells in the blood can be increased, the thickness ofCFL generated when the blood flows in a straight pipeline can be reduced, the thickness of CFL generated when the blood flows in a T-shaped pipeline can be reduced, and blood perfusion can be increased. The application is applied to the field of polymer drag reducers.

The invention relates to a nursing device for the vascular diseases around the lower limbs, pedal type movement is adopted, the lower limbs can be moved, a massage device is additionally arranged on a pedal according to the movement state of a patient, the massage device is placed on the pedal to compress a telescopic box, and a control rod presses an arc-shaped plate to contract so that a driving gear is meshed with ring teeth, so that the exercise amount is increased and the massage device is driven; the massage device is used for massaging when a patient treads the pedal to rotate, the massage force is adjusted through a cam, and the massage frequency changes along with the movement of the patient; a damping device is arranged and is composed of a fixed disc with a conical inner surface and a moving disc, a plurality of arc-shaped holes are formed in the moving disc, damping rods and damping springs are arranged in the holes, when the moving speed is too high, the damping rods slide outwards, meanwhile, the damping rods abut against the conical surface to enable the damping springs to be continuously compressed, and therefore the situation that a patient steps on a pedal too fast to injure the blood vessels and muscles of the legs is prevented; and the training intensity can be increased for the patient.

The invention provides a peripheral vascular disease detection assisting device, and relates to the technical field of peripheral vascular disease detection assisting, the peripheral vascular disease detection assisting device comprises a base, the main body of the base is of an annular structure, the inner side of the base is fixedly connected with a fan, the fan is also of an annular structure, a groove is formed in the base, and the groove formed in the base is used for air outlet of the fan; the problems that in the prior art, a patient needs to make corresponding posture cooperation during detection work, and good detection work cannot be conducted on the diseased limbs of the patient if the patient lacks to make a cooperation posture or does not cooperate for detection are solved, and surrounding personnel are prompted that the current device is conducting detection work through air outlet of turbulent flow holes; when the outer side of the device is covered with a covering object, a certain gap can be formed between the covering object and the device through the air flow sprayed out of the turbulent flow holes, and then the design that the device is protected against influence during detection work is achieved.