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Anti-fungal-infection pharmaceutical composition and use thereof

A composition and antifungal technology, applied in the field of medicine, can solve the problems of high liver and kidney toxicity, difficult drug resistance, high price, etc., achieve high tissue concentration, reduce microbial drug resistance and human side effects, and low price

Active Publication Date: 2020-06-19
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are still many problems in the treatment of fungal infections clinically. On the one hand, the choice of clinical drugs is limited, and there are problems such as high liver and kidney toxicity or high prices; The drug phenomenon is becoming more and more serious, and the degree of drug resistance is also getting higher and higher. Drug resistance has brought serious difficulties to clinical antifungal treatment.

Method used

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  • Anti-fungal-infection pharmaceutical composition and use thereof
  • Anti-fungal-infection pharmaceutical composition and use thereof
  • Anti-fungal-infection pharmaceutical composition and use thereof

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Embodiment Construction

[0018] The following describes the technical solutions in the embodiments of the present invention clearly and completely. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention. The used materials, reagents, etc., unless otherwise specified, are reagents and materials available from commercial sources.

[0019] In vitro antifungal effects

[0020] 1. Experimental strains and materials

[0021] (1) Test strains: Cryptococcus neoformans ATCC 32609, Candida albicans ATCC 10231, Candida parapsilosis ATCC 22019, Saccharomyces cerevisiae ATCC 44076

[0022] (2) Test drug:

[0023] a. Compound of formula (I): provided by Shanghai Huzheng Biotechnology Co., Ltd.;

[0024] b. Itraconazole: Provided by Longshengda Bi...

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Abstract

The invention belongs to the technical field of drugs, and particularly relates to a anti-fungal-infection pharmaceutical composition and use thereof. An alkaloid compound of a formula (I) has the useof anti-fungal infections, and a new candidate drug is provided for the treatment of fungal infections. In addition, it is further found that the combined use of the compound of the formula (I) and itraconazole has a synergistic antifungal effect through a combined drug experiment, while the amount of active ingredients of the drug is reduced, the drug resistance of microorganisms and the human side effects are reduced, and a foundation is further laid for the screening research of novel antifungal drugs.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition for anti-fungal infection and its use. Background technique [0002] Fungi are widely found in nature. They are a kind of eukaryotic microorganisms with various forms and varieties, with more than 300,000 species. Among them, there are about 280 kinds of fungi that are pathogenic to humans. Mycosis refers to fungal infections caused by pathogenic fungi invading human skin, subcutaneous tissues, mucous membranes, and human tissues and organs. According to the different invasion sites, it can be divided into superficial fungal diseases and deep fungal diseases. Superficial mycosis mainly refers to infectious skin diseases of the epidermis, hair and nails (toe) caused by dermatophytes. It is a relatively common disease with a high incidence. Clinically, patients with superficial fungal infection account for more than 90% of patients with fungal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61K31/496C07D215/233A61P31/10
CPCA61K31/47A61K31/496A61P31/10C07D215/233A61K2300/00
Inventor 陈忠新牟景龙王子一李强韩雪王子函王时李雪房良
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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