Application of n6022 in the preparation of drugs for preventing and treating aortic dissection and aortic aneurysm

A technology for the treatment of aortic dissection, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., to reduce the occurrence of hematoma, maintain the integrity, and reduce the excessive deposition of collagen on the vessel wall

Active Publication Date: 2021-08-24
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether N6022 can improve aortic dissection and aortic aneurysm and its mechanism has not yet been studied or reported.

Method used

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  • Application of n6022 in the preparation of drugs for preventing and treating aortic dissection and aortic aneurysm
  • Application of n6022 in the preparation of drugs for preventing and treating aortic dissection and aortic aneurysm
  • Application of n6022 in the preparation of drugs for preventing and treating aortic dissection and aortic aneurysm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Inhibitory effect of N6022 on occurrence and rupture of aortic dissection

[0020] In order to explore the effect of N6022 on the occurrence and rupture of aortic dissection, we selected SPF grade 4-week-old C57BL / 6 mice (purchased from the Medical Experimental Animal Center of Nanjing Medical University) and randomly divided them into five groups: solvent control group (Control+ DMSO), aortic dissection model solvent control group (BAPN+DMSO) and three different N6022 concentrations (0.01mg / kg / day, 0.1mg / kg / day, 1mg / kg / day) aortic dissection model administration groups. Wherein the aortic dissection model is when the mice are 4 weeks old, by infiltrating β-aminopropionitrile (BAPN) 1g / kg / day in the drinking water, and injecting different concentrations of N6022 (0.01mg / kg / day, 0.1mg / kg / day, 1mg / kg / day), the survival of the mice was observed every 5 days, and after 4 weeks, the aorta of the mice was isolated, and the incidence rate and rupture rate of aortic...

Embodiment 2

[0023] Example 2: Inhibitory effect of N6022 on formation and rupture of aortic aneurysm

[0024] In order to explore the effect of N6022 on tumor formation and rupture in aortic aneurysm model mice, we selected SPF grade 8-week-old male ApoE - / - Mice (purchased from Nanjing Junke Bioengineering Co., Ltd.) were randomly divided into three groups: solvent control group (Saline+DMSO), aortic aneurysm model solvent control group (AngII+DMSO) and aortic aneurysm model administration group ( AngII+N6022). That is, when the mice were 8 weeks old, an osmotic micropump (Alzet, USA, 2004 model) was implanted subcutaneously through the back, the control group was given normal saline, the aortic aneurysm model solvent control group and the aortic aneurysm model administration group were given Ang II ( 1000 ng / kg / min), and the control solvent DMSO or N6022 (0.1 mg / kg / day) was injected into the tail vein. The mortality rate of mice was observed every 5 days, and the formation of aortic a...

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Abstract

The application of N6022 in the treatment of aortic dissection and aortic aneurysm involves the cardiovascular field. In mouse models of aortic dissection and aortic aneurysm, tail vein injection of N6022 can inhibit the expansion of the aorta, reduce the incidence and mortality of arterial dissection and aortic aneurysm; and N6022 can reduce the rupture of aortic aneurysm, inhibit The occurrence of hematoma in the inner wall of the lumen and the excessive collagen deposition on the vessel wall maintain the integrity of the elastic fibers of the vessel wall and treat aortic dissection and tumor diseases. The invention opens up a new application field of N6022, and provides a meaningful reference for preventing and treating aortic dissection and aortic aneurysm diseases and improving vascular pathological changes.

Description

technical field [0001] The invention belongs to the technical field of aortic dissection and aortic aneurysm treatment, in particular to the application of N6022, a nitrosoglutathione reductase (GSNOR) inhibitor, in the prevention and treatment of aortic dissection and aortic aneurysm. Background technique [0002] Aortic dissection and aortic aneurysm are the most serious large-vessel diseases in aortic diseases, and their pathological manifestations are progressive dilation of the aorta. Due to their characteristics of insidious onset and fatal rupture, they have become a major public health problem. In the early stage of the disease, the middle layer of the blood vessel undergoes structural abnormalities such as degeneration and degeneration, and usually no specific symptoms or signs appear before the vessel ruptures; as the diameter of the tumor increases, the probability of rupture increases significantly, accompanied by intimal tear and false lumen After tumor rupture,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4178A61P9/00A61P9/14
CPCA61K31/4178A61P9/00A61P9/14
Inventor 季勇谢利平张曦月缪青张益华高婕
Owner NANJING MEDICAL UNIV
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