The invention discloses a method of making external health-care massage wine, comprising the following steps: (1), preparing materials: 49 black soybean kernels, 49 small red bean kernels, 20 g of Radix Saposhnikoviae, 20 g of Radix Notoginseng, 10 g of Rhizoma seu Radix Notopterygii, 20 g of frankincense and 20 g of myrrh; (2), roughly soaking; loading 1000 ml of baijiu higher than 50 international alcohols by volume into a container, and roughly soaking in the container, the black bean and small red bean prepared in step (1) for 24 hours; (3), soaking: pouring the Radix Saposhnikoviae, Radix Notoginseng, Rhizoma seu Radix Notopterygii, frankincense and myrrh prepared in step (1) into another container, filtering wine made in step (2), pouring into the container, soaking for 49 days, and sealing to obtain the finished massage wine. The massage wine made by the method can expel wind and remove cold, activate blood to dredge collaterals and subside swelling to arrest pain, has great regulatory effect for various bone and joint pains such as rheumatism, rheumatoid, cervical pain and lumbar pain, gout, arthroncus of knee, and removal of wind, cold, damp and the like in body, is free of any side effect and is safe, reliable and effective.