40 results about "Artery dissection" patented technology

The invention discloses a covered stent for an aortic dissection surgery, a delivery device and a use method thereof. The stent comprises a main body, wherein the main body decreases progressively from the heart near end with a large diameter to a far end with a small diameter, and the superior border of the middle piece of the main body is a rotary island; a tectorial membrane is arranged except the rotary island, and the two ends of the main body and the rotary island are provided with positioning marks. The delivery device comprises a delivery sheathing canal, a suture and a traction guide wire, wherein the suture is sewn on the outer side surface of the covered stent, and the two side edges of the covered stent at the near end of the left subclavian artery are sewn up by the suture; the stent is closed up to be in a semi-contraction state by the traction guide wire through the suture, and the covered stent is closed up and wrapped in the delivery sheathing canal; the delivery sheathing canal is provided with a steeple, and the far end of the traction guide wire penetrates through the handle of the delivery sheathing canal and is fixed. The covered stent for the aortic dissection surgery is used for a dissecting aneurysm surgery of the lesser curvature side of aortic arch and an interventional minimally invasive surgery of an aortic dissection near the brachiocephalic trunk, so that the trauma of a thoracotomy is avoided, and the athe lumen crevasse occlusion is directly implemented.

A bloodstream dilating device 1 is composed of an elastic member 2 extending in a direction of blood flow in a true lumen 115. The elastic member 2 pushes the inner wall of the true lumen 15 outward to dilate the bloodstream. An aortic dissection treating device includes an obturator and a fixing member for fixing the obturator to the inner layer of an aorta. The obturator is inserted up to the point that it can cover an entry port formed in the aorta. The obturator is deformed along the periphery of the entry port in the inner layer by blood pressure to occlude the entry port.

The invention discloses a plastic covered aortic dissection stent and an aortic dissection stent.The plastic covered aortic dissection stent comprises a tubular covering membrane and multiple annular supports sequentially sewn on the covering membrane in the axial direction and is characterized in that the annular supports on one part of the covering membrane are semi-sewn supports, the semi-sewn supports are provided with non-sewn areas which can be separated from the covering membrane, and the covering membrane corresponding to the internally-bent side of the non-sewn areas breaks away from the semi-sewn supports to be folded internally in a bent state.The semi-sewn supports are distributed at the bent positions after the plastic covered aortic dissection stent is implanted.The number of the semi-sewn supports is at least two sequentially-adjacent circles.When the plastic covered aortic dissection stent is bent, non-sewn areas of every two adjacent annular supports located on the internally-bent side can be overlapped, and the covering membrane in the non-sewn areas is folded towards the inside of the stent to maintain the bent state of the covered stent.

The invention discloses application of N6022 in treatment of aortic dissection and aortic aneurysm, and relates to the field of cardiovascular diseases. In mouse models of aortic dissection and aorticaneurysm, dilation of aorta can be inhibited after intravenous injection of the N6022 into tail veins, thereby reducing incidence and mortality of aortic dissection and aortic aneurysm; and moreover,the N6022 is capable of reducing rupture of aortic aneurysm, inhibiting occurrence of hematoma in inner walls of lumen and excessive collagen deposition on vascular walls, maintaining integrity of elastic fibers in the vascular walls, and treating the aortic dissection and the aortic aneurysm. The application of the N6022 in the treatment of the aortic dissection and the aortic aneurysm opens upa new application field of the N6022, and provides a meaningful reference for the prevention and the treatment of the aortic dissection and the aortic aneurysm diseases as well as improvement of vascular lesions.

Medical methods and devices for treating aortic dissections. A catheter-based cutting device permits cutting a septum of acute or chronic aortic dissections, in a retrograde manner. The catheter includes a base section having a central lumen therethrough, two flexible arms extending from a distal end thereof, where each arm has a channel therethrough for a passage of a guide wire. With distal ends of the two flexible arms separated, the two arms form a Y-shape with the base section. With distal ends of the two flexible arms together, the two arms have a longitudinal profile, about a periphery thereof, identical to a longitudinal profile of the base section. A non-mechanically actuated cutting component resides between the two arms in a vicinity of the distal end of the base section. The cutting component faces distally outward between the two arms with the distal ends of the two flexible arms separated.

The invention discloses an aortic dissection vascular stent and a manufacturing method thereof. The aortic dissection vascular stent comprises a stent body and a membrane attached to the outer side of the stent body, the stent body is formed by multiple coils in a spiraling mode, and each coil is formed by multiple waves. The manufacturing method includes the steps that a spatial continuous spiral wave curve is constructed through a spatial cylindrical coordinate system; a three-dimensional model of the stent body is obtained in a scanning mode; an entity model of the stent body is made according to the three-dimensional model; a metal wire is wound around the entity model to obtain the stent body; heat shaping and electropolishing are carried out on the stent body; the membrane is arranged on the outer side of the stent body in an electrospinning or hot-pressing mode. Bending of the vascular stent in the bent lumen is uniformly distributed in the whole vascular stent, so that the fitness of the vascular stent is improved, and the situation that the vascular wall is bent or damaged is avoided. Besides, the vascular stent is specially designed for the aortic dissection and is simple in structure, convenient to operate, appropriate in supporting force and suitable for the pathological characteristics of the aortic dissection.

The invention belongs to the technical field of medicine and discloses an aortic dissection detecting marker and a marker evaluation method. The aortic dissection detecting marker is MMP-9+D-Dimer+ET-1+Calponi. The evaluation method comprises the following steps: performing serological analysis on the selected marker MMP-9+D-Dimer+ET-1+Calponi with ELISA; drawing a ROC (receiver operating characteristic) curve and adopting statistical software SPSS21.0 for analysis. Specificity of three indexes including ET-1, D-Dimer and MMP-9 are higher and are 98.6%, 98.7% and 97.1% respectively, sensitivity of the three indexes are 80.0%, 81.7% and 81.7%, and diagnostic accuracy of the three indexes are also higher and are 86.4%, 87.5% and 87.5%.

The present invention discloses a diagnostic marker for aortic dissection. The diagnostic marker comprises at least one of a protein inhibitor 16 and fibrinogen-like protein 1. The present invention also discloses an application of the diagnostic marker for aortic dissection in diagnosis of the aortic dissection, an application of the diagnostic marker for aortic dissection in production of diagnostic products for diagnosis of the aortic dissection, an application of the diagnostic marker for aortic dissection for distinguishing the aortic dissection from acute coronary syndrome and an application of the diagnostic marker for aortic dissection in production of diagnostic products for distinguishing the aortic dissection from acute coronary syndrome. The diagnostic marker for aortic dissection is screened out by proteomic principles, and verified by a large number of samples. The diagnostic marker for aortic dissection can effectively improve diagnostic rate of the aortic dissection anddiagnostic rate for distinguishing the aortic dissection from acute coronary syndrome.

The invention discloses an aortic dissection surgery risk prediction method based on a lifting tree model. The method comprises the steps of 1, carrying out data preprocessing; complementing data loss parts in the operation records to form a database containing the operation records; step 2, carrying out data mining; processing the data in the database based on the decision tree model; 3, analyzing a result; analyzing a data mining processing result to evaluate the validity of a data mining algorithm; and 4, carrying out knowledge application; and applying the model to data corresponding to the current aortic dissection surgical operation to predict the risk of the current operation. The model has 100% accuracy rate for predicting the death risk after the aortic dissection surgery, compared with other prediction methods, the accuracy is higher, the prediction result can give key factors of death after the aortic dissection surgery, decision basis can be provided for doctors and patients in the future, and a medical policy maker can fully utilize and arrange medical resources.

The invention relates to a method for predicting ICU duration after aortic dissection cardiac surgery. The method comprises the following steps: acquiring ICU data from an ICU database after aortic dissection cardiac surgery, and preprocessing the data; on the basis of a kendall correlation coefficient, carrying out feature extraction on the preprocessed ICU data, and taking features with the correlation coefficient value higher than a preset threshold value; constructing a machine learning model, and training the constructed machine learning model based on the extracted ICU data features; after training is completed, predicting the ICU duration of the patient through real-time ICU data after the aortic dissection cardiac surgery. Through the method, the ICU duration of the patient after the arterial dissection cardiac surgery can be predicted, the mastery degree of the patient and family members on the illness state and the recovery process is improved; meanwhile, a powerful support can be provided for medical personnel to prepare a medical plan.

The invention belongs to the field of medical instruments and relates to a device for being implanted in the abnormal bulging position of an arterial canal wall. The device comprises a bag capable of being implanted in the abnormal bulging position of the arterial canal wall and bulging, when the bag bulges, the bag has 3D modeling anatomy three-dimensional morphological features conforming to the implanting position, and therefore blood cannot flow into the abnormal bulging position of the arterial canal wall from an arterial canal. According to the device, the blood cannot flow into the abnormal bulging position of the arterial canal wall from the arterial canal, blood flow smoothness in the tumor-carrying arterial canal is kept, blood flow smoothness of branch blood vessels of the arterial canal is kept, thus, the device can be used for treating the diseases such as intracranial aneurysms, visceral aneurysms, false aneurysms, aortic aneurysms, artery dissection and aortic dissection, and a new way for aortic disease interventional therapy is expected to be opened up.

The invention provides application of R-ketorolac in prevention and treatment of aortic dissection and aortic aneurysm. The R-ketorolac is orally taken to inhibit pathological expansion of aorta and reduce the occurrence rate and death rate of the aortic dissection and aortic aneurysm; and the R-ketorolac can inhibit the occurrence of vascular wall inflammatory reaction, reduce rupture of aortic aneurysm bodies, inhibit the occurrence of hematoma in the inner wall of a lumen, maintain the integrity of vascular wall elastic fibers and treat the aortic dissection and aortic aneurysm. The invention develops a new application field of the R-ketorolac, and provides a significant reference for preventing and treating aortic dissection and aortic aneurysm diseases and improving vascular lesion conditions.

The invention discloses a compound preparation containing benidipine hydrochloride and metoprolol tartrate and an application thereof; for the preparation, the benidipine hydrochloride and the metoprolol tartrate are taken as active pharmaceutical ingredients. The compound pressure-reducing preparation adopts drug combination and is good in efficacy, less in side effects and high in performance-price ratio; the compound preparation is taken once per day, the administration is convenient and the drug compliance of a patient can be improved. The preparation can be prepared into oral formulations in different forms, thereby realizing synergic and complementary action of drugs and enhancing the treatment effect of the compound preparation. The compound preparation has significant effects for treating hypertension and can also be used for treating angina pectoris, myocardial infarction and arrhythmia, as well as hypertrophic cardiomyopathy, aortic dissection, hyperthyroidism, cardiac neurosis, chronic stable heart failure and other symptoms. The compound preparation is low in price, simple to prepare and convenient to popularize and apply.

The invention provides a medicine for treating artery-related diseases and an application thereof. Specifically, the invention provides an application of the compound shown in the formula I in treating artery related diseases. Experiments show that the compound shown in the formula I has a remarkable curative effect on arterial lesions such as aneurysm, interwall hematoma and/or arterial dissection.

The invention discloses a method for constructing an aortic dissection model by using a biological material, which comprises the following steps of: 1, acquiring an aorta of an in-vitro mammal, and reserving a branch artery with a proper length on the aorta; 2, folding the aorta inwards and outwards to expose the aorta intima to the outer side; 3, selecting the position of a first dissection gap, cutting the aorta intima to form the first dissection gap with set depth and width, and separating the aorta intima at the first dissection gap from the aorta adventitia; 4, inserting a long sheet-shaped first punching tool into the first dissection gap, and punching towards the far end of the aorta, so as to separate the aorta intima and the aorta mesolamella on the punching path and manufacture an aorta dissection with set length and width; and 5, folding the aorta inwards and outwards again to expose the aorta adventitia to the outer side, thus completing aorta dissection construction. An aortic dissection model based on a biological material can be prepared through the method.

A system for treating aortic dissection includes a sinotubular junction magnetic array having a first plurality of magnetic elements, a counter-magnetic array having a second plurality of magnetic elements, and an ascending aortic stent graft comprising a third plurality of magnetic elements. A method for treating aortic dissection includes the steps of positioning a sinotubular junction magnetic array at the sinotubular junction, advancing counter magnetic constructs from the femoral vein and positioning them in the right atrium, expanding the sinotubular junction ring at a target position, advancing the counter magnetic array to form an at least partial circumferential seal, and advancing and positioning an ascending magnetic graft within an interior of the sinotubular junction magnetic array. A system for treating aortic dissection, a fixation device for anchoring an ascending aortic stent graft, and a transcatheter device for treating aortic dissection are also described.

The invention provides an aortic dissection endoluminal repair postoperative false lumen blood flow state evaluation method, which comprises the following steps of: recoding, naming and sequencing a .IMA format file in a four-dimensional blood flow magnetic resonance imaging original file, and respectively exporting anatomical information and blood flow information contained in the .IMA format file; importing exported anatomical information and blood flow information data into an MATLAB platform to be preprocessed, processing original data through an autonomous coding program, and generating an .ENCAS format file; selecting an interested target blood vessel plane needing to be processed for analysis; selecting different blood flow parameters to calculate a time-varying quantitative relation of different blood flow dynamic parameters passing through normal aorta or real and false cavities of a dissection; and comparing different hemodynamic parameters in the true cavity and the false cavity in different planes as well as difference changes at different time points in a cardiac cycle, and analyzing hemodynamic parameters and a blood flow distribution mode in the false cavity after the aortic endoluminal repair.