8 results about "Artery dissection" patented technology

This invention discloses a targeted nanocarrier for the diagnosis and treatment of arterial dissection and its preparation method. The targeted nanocarrier is composed of a macromolecular prodrug self-assembly constructed by covalently linking the NLRP3 inhibitor CY-09 and oxidized fucoidan through phenylboronic acid ester bonds and imine bonds, using iodine contrast agent ICA as a connecting bridge. The targeted nanocarrier prepared by this invention possesses good stability, drug release characteristics, excellent dissection targeting, and dual responsiveness to reactive oxygen species and acidic microenvironments, demonstrating significant imaging diagnostic and therapeutic effects on arterial dissection.

The application provides an aortic dissection postoperative cardiopulmonary function rehabilitation device, and belongs to the technical field of cardiopulmonary rehabilitation. The aortic dissection postoperative cardiopulmonary function rehabilitation device comprises a fixing structure and a clamping structure, the fixing structure comprises a first gasket, a second gasket, a U-shaped frame, a fixing assembly, a rectangular shell, an adjusting assembly, an arc-shaped clamping plate and two connecting belts, the first gasket is rotationally connected with the second gasket, the U-shaped frame is slidingly connected with the first gasket, the fixing assembly is connected with the U-shaped frame, and the rectangular shell is connected with the fixing assembly. In the application, the aortic dissection postoperative cardiopulmonary function rehabilitation device can conveniently avoid foot deviation during rehabilitation training, improve the training effect, and conveniently adjust the position of the U-shaped frame according to the height of a user, thereby improving the practicability of the device.

This invention provides a method and system for predicting the risk of aortic remodeling after aortic dissection, comprising the following steps: receiving CTA images of the patient's chest and abdomen at multiple time points, such as preoperative and short or mid-operative postoperatively, and obtaining aortic segmentation results based on the CTA images; obtaining the displacement field of each voxel point between the two time points based on the aortic segmentation results, and obtaining vascular deformation mapping results based on the displacement field; extracting multi-dimensional features from the three-dimensional aortic segmentation model and the vascular deformation mapping results respectively; and predicting the risk of adverse aortic remodeling after surgery based on the multi-dimensional features. The beneficial effects of this invention are: by comprehensively utilizing multi-dimensional, dynamic, and static features, the prediction model constructed by this invention theoretically has higher discrimination and calibration than existing single-index models. Therefore, this invention can detect early, local abnormal deformations that cannot be detected by traditional diameter measurement, significantly advancing the risk identification time point.

The application provides an aortic dissection rupture sealing device, which comprises an anchoring part, a hollow flow channel, and an intima around the rupture, so as to prevent the fluid communication between the true lumen of the aorta and the false lumen formed at the rupture; a stent, which is adjustably coupled to the anchoring part, has a connecting end and a free end, and at least the free end of the stent is located in a branch blood vessel; and the stent has a hollow structure in communication with the hollow flow channel and is supported in the branch blood vessel to communicate the true lumen and the branch blood vessel. The above scheme can avoid the continuous expansion of the false lumen caused by the incomplete sealing of the rupture and residual shunt, and at the same time, the blood supply of the blood vessel channel is retained to ensure the stability of the blood supply of the branch blood vessel, which is beneficial to meet the blood supply demand of the internal organs, spinal cord and the like supplied by the branch blood vessel.

An explainable artificial intelligence system for early prediction of missed severe diagnoses in intensive care unit patients is provided. The system comprises a data processing module configured to receive and process electronic health record data including patient demographics, vital signs, laboratory results, and diagnostic codes. A machine learning module with ensemble, deep learning, and large language models analyzes processed data to predict likelihood of severe diagnoses including acute myocardial infarction, acute pulmonary embolism, bacterial pneumonia, aortic dissection, meningitis, spinal abscess, bacterial endocarditis, and arterial thromboembolism. An explainability module generates feature importance rankings and provides interpretable explanations for predictions.

This invention discloses a method and system for predicting in-hospital mortality risk in patients undergoing acute type A aortic dissection surgery based on interpretable machine learning. The method includes: collecting clinical data from patients undergoing acute type A aortic dissection surgery and constructing an original feature dataset; evaluating the feature importance of each feature in the original feature dataset to obtain a score for each feature, and filtering based on the scores to obtain a core feature dataset; inputting the core feature dataset corresponding to the target patient into a pre-trained in-hospital mortality risk prediction model, and outputting the predicted in-hospital mortality probability of the target patient; calculating the feature contribution corresponding to the predicted in-hospital mortality probability, and generating an interpretable result for the mortality risk prediction of the target patient. The technical solution of this invention can reduce model complexity, improve model generalization ability, and improve prediction accuracy and interpretability.

The present invention provides a pharmaceutical composition containing ticagrelor for use in reducing or preventing thromboembolic events before and / or during and / or after neurovascular arterial procedures in a patient requiring the use of the pharmaceutical composition containing ticagrelor, comprising administering an effective amount of the pharmaceutical composition containing ticagrelor to a patient, wherein the pharmaceutical composition is an aqueous solution containing a solubilizing agent for ticagrelor and the pharmaceutical composition is administered intravenously; wherein the patient suffers from a cerebral aneurysm, cerebral arteriosclerosis, cervical arteriosclerosis, neurovascular carotid dissection or carotid dissection.

The application belongs to the technical field of disease diagnosis, and particularly relates to the use of CX3CL1 as a biomarker of acute type A aortic dissection. The application finds that CX3CL1 is a key inflammatory mediator of acute type A aortic dissection, and its plasma level is significantly positively correlated with neutrophil infiltration, IL-6, IL-8, IL-10, D-dimer and NT-proBNP. It is proved by characteristic curve analysis that there is a significant correlation between the CX3CL1 level and the severity of ATAAD. By evaluating the expression level of CX3CL1 protein in peripheral blood of a subject, an evaluation result related to the risk of suffering from acute type A aortic dissection is generated, non-invasive, fast and low-cost detection can be realized, and the problem that patients with renal dysfunction or contrast agent allergy cannot use CT angiography for diagnosis is solved.