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Pharmaceutical composition used for preventing and controlling atherosclerosis and application thereof

An atherosclerosis and composition technology, which is applied in the field of medicine, can solve the problems of no obvious advantage in long-term curative effect and unsatisfactory curative effect, so as to improve aortic lesions, eliminate the formation of aortic plaques, and increase HDL- Effect of C content

Active Publication Date: 2014-07-09
HUNAN YEARTH BIOTECHNOLOGICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the main treatment for AS is the use of angiogenesis inhibitors and lipid-lowering drugs, but the efficacy is not ideal
Although interventional therapy can recanalize blood vessels, restenosis is still a medical problem that cannot be solved at present, especially the long-term efficacy has no obvious advantage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 The treatment of ezetimibe / warfarin sodium on atherosclerosis model rats

[0018] SPF grade SD rats, male, weighing 200±20g. 85 SD rats were taken, and after being adaptively fed with common feed for 1 week under the experimental conditions, the experimental animals were randomly divided into 6 groups: 10 rats in the blank group, 15 rats in the model group, 15 rats in the ezetimibe group, and 15 rats in the Xinhua group. Fifteen rats in the farin sodium group, 15 rats in the compound A group and 15 rats in the compound B group were injected intraperitoneally with vitamin D3 injection (600,000 IU / kg) and fed high-fat feed (formula: 3 % cholesterol + 0.5% sodium cholate + 0.2% propylthiouracil + 5% sugar + 10% lard + 81.3% basal feed) for modeling; the blank group was injected with the same volume of normal saline and fed with normal feed. After feeding high-fat feed for two months, each drug group was given the corresponding drug by intragastric administration...

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Abstract

The invention discloses a pharmaceutical composition used for preventing and controlling atherosclerosis and application thereof. Active components of the pharmaceutical composition comprise ezetimibe and warfarin. According results of experimental investigation, a combination of ezetimibe and low-dosage warfarin sodium is capable of substantially adjusting lipid metabolism, reducing the content of TG, TC, LDL-C and MDA in serum, improving activity of SOD, increasing the content of HDL-C, inhibiting lipid peroxidative damage, suppressing and eliminating plaque formation of aortas, improving conditions of aortic lesions and achieving an unexpected curative effect of cooperative antiatherosclerosis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for preventing and treating atherosclerosis and its application. Background technique [0002] Cerebrovascular disease is a disease with high morbidity, high disability and high mortality. The main pathological process is based on vascular wall lesions, changes in blood components and (or) hemodynamics, resulting in ischemic or hemorrhagic diseases. There are many causes, one of which is atherosclerosis (AS), which can lead to narrowing of the arterial lumen, insufficient blood supply to the brain tissue, and even serious consequences due to plaque shedding and blockage of cerebral blood vessels. [0003] The main pathological feature of AS is the subintimal lipid deposition in certain parts of the artery, accompanied by the proliferation of smooth muscle cells and fiber components, and gradually develops into local plaques, which thicke...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/397A61P9/10A61K31/37
Inventor 于法周
Owner HUNAN YEARTH BIOTECHNOLOGICAL CO LTD
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