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Rapid Quantitative Screening Method and Application of Antioxidant Active Components of Glycyrrhizae

A technology for antioxidant activity and screening methods, applied in measuring devices, material separation, analytical materials, etc., can solve the problems of licorice medicinal substances such as unclear basis and quality

Active Publication Date: 2022-01-11
THE SECOND HOSPITAL OF SHANDONG UNIV
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  • Description
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Problems solved by technology

[0003] At present, the chemical composition analysis of licorice includes GC-MS, HPLC content determination, HPLC fingerprint and HPLC-MS technology, etc., and more and more abundant composition information can be obtained. The index components of the drug are often not related to the efficacy of the drug, so the content of the index components does not really represent its quality

Method used

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  • Rapid Quantitative Screening Method and Application of Antioxidant Active Components of Glycyrrhizae
  • Rapid Quantitative Screening Method and Application of Antioxidant Active Components of Glycyrrhizae
  • Rapid Quantitative Screening Method and Application of Antioxidant Active Components of Glycyrrhizae

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Experimental program
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Embodiment 1

[0029] Preparation of the test solution Take 0.75 g of licorice sample powder from different origins, accurately weigh the weight, put it in a stoppered Erlenmeyer flask, add 15 mL of methanol precisely, seal it up, ultrasonicate for 30 min, filter, and the filtrate passes through 0.45 μm Microporous membrane, stored in a refrigerator at 4°C, for later use.

[0030] Preparation of DPPH solution Accurately weigh the DPPH standard, add methanol to the mark, and configure the solution to be 80 μmol L -1 The DPPH methanol solution was stored in a refrigerator at 4 °C until use.

[0031] Preparation of Vc reference substance solution: take an appropriate amount of L(+)-ascorbic acid standard substance, accurately weigh the weight, add distilled water to make the concentration 0.05mg·mL -1 The stock solution was stored in a 4°C refrigerator for later use.

[0032] HPLC-UV-DPPH online system Chromatographic conditions HPLC system chromatographic conditions: Agilent Eclipse XDB-C 1...

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Abstract

The invention relates to a rapid quantitative screening method of licorice antioxidative active ingredients and an application thereof, belonging to the technical field of quality evaluation and control of traditional Chinese medicines. Aiming at the existing problems in the quality control of the efficacy of licorice at the present stage, using its antioxidant activity, a rapid screening method for its active components and a rapid quantitative determination method for the antioxidant activity of each component were established. Screen the antioxidant active ingredients in the traditional Chinese medicine licorice, and make a quantitative evaluation of the antioxidant activity of each ingredient, research and optimize the quality evaluation method of licorice, realize the correlation between quality evaluation and drug efficacy, and more truly reflect the quality of decoction pieces. The study can also provide some data support for the research on the basis of licorice antioxidant substances.

Description

technical field [0001] The invention relates to a rapid quantitative screening method of licorice antioxidative active ingredients and an application thereof, belonging to the technical field of quality evaluation and control of traditional Chinese medicines. Background technique [0002] Licorice is the dry root and rhizome of Glycyrrhizauralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhizaglabra L. of the leguminous plant Glycyrrhizauralensis Fisch., mainly distributed in Northeast China, North China, Gansu, Xinjiang and other places. Licorice has the functions of invigorating the spleen and replenishing qi, clearing heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and relieving pain, and harmonizing various medicines. Relieves drug toxicity and potency. Modern pharmacological studies have shown that licorice has strong antioxidant activity, and as a natural antioxidant, it has been widely used in many fields. And its anti-inflammatory...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/72G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/72G01N30/8675G01N30/8686G01N2030/047
Inventor 周蒙周倩戴衍朋蒋海强化敏
Owner THE SECOND HOSPITAL OF SHANDONG UNIV
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