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Gene marker for esophageal cancer prognosis evaluation

A gene marker and prognosis assessment technology, applied in the field of medical molecular biology, can solve the problems of abnormal molecular changes, relatively few studies on the relationship between esophageal cancer gene mutation and prognosis, etc.

Active Publication Date: 2021-05-11
GENESEEQ TECH INC +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Although many studies have found that there may be a large number of molecular abnormalities in the development of esophageal cancer, among which genes with high frequency include TP53, NOTCH1, PIK3CA, RB1, CDKN2A, etc., but the relationship between gene variation and prognosis of esophageal cancer relatively little research

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  • Gene marker for esophageal cancer prognosis evaluation
  • Gene marker for esophageal cancer prognosis evaluation
  • Gene marker for esophageal cancer prognosis evaluation

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Embodiment Construction

[0027] In the study of the present invention, targeted panel sequencing was performed on tumor tissues from 69 Asian patients with esophageal cancer. Using univariate analysis, 6 gene variants were shown to be potential prognostic biomarkers of overall survival in patients with esophageal cancer. To improve the accuracy of prediction, a multivariate joint model was constructed and analyzed in an independent TCGA cohort of 143 patients with esophageal cancer verified in .

[0028] The amplification mentioned in the present invention refers to the variation of gene copy number, specifically refers to the amplification of DNA fragments ranging in size from 1 kb to 3 Mb in a local region of the chromosome, resulting in the overexpression of the encoded protein.

[0029] The deletion mentioned in the present invention refers to the gene copy number variation, specifically refers to the deletion of DNA fragments with a size ranging from 1 kb to 3 Mb in a local region of the chromoso...

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Abstract

The invention relates to a gene marker for esophageal cancer prognosis evaluation, and belongs to the technical field of medical molecular biology. The gene marker for esophageal cancer prognosis evaluation is found through screening and analysis of a large number of samples, and comprises the following genes: YAP1, MYC, BAP1, BRIP1, WRN and RB1; and a combined marker for evaluating the total survival time (OS) of esophageal cancer patients is constructed, and can effectively predict high-risk / low-risk esophageal cancer patients.

Description

technical field [0001] The invention relates to a gene marker for evaluating the prognosis of esophageal cancer, and belongs to the technical field of medical molecular biology. Background technique [0002] The morbidity and mortality of esophageal cancer (Esophageal cancer, EC) in my country are higher than the global average, and the successful rate of incidence and death in men (16.50 / 100,000 and 12.66 / 100,000) is higher than that of women (5.92 / 100,000 and 4.17 / 100,000). More than 95% of patients with esophageal cancer in China are esophageal squamous cell carcinoma (ESCC), while in European and American countries, most of them are esophageal adenocarcinoma (EAC). Smoking and drinking are two high risk factors for ESCC. Other risk factors include betel nut chewing and hot food consumption. Obesity is an important risk factor for EAC. The 5-year survival rate of esophageal cancer depends on many factors, including tumor size, degree of differentiation, clinical stage, ...

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Application Information

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IPC IPC(8): C12Q1/6886C12Q1/6858
CPCC12Q1/6886C12Q1/6858C12Q2600/118C12Q2600/156C12Q2535/122C12Q2537/165Y02A90/10
Inventor 杨哲戴洪海邵阳汪笑男逄娇慧刘璟文
Owner GENESEEQ TECH INC
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