Application of parthenolide in preparation of MCR-1 enzyme inhibitor

Abstract

The invention relates to application of parthenolide in preparation of an MCR-1 enzyme inhibitor. A checkerboard method and a time-sterilization curve method verify that parthenolide can recover the bactericidal activity of polymyxin on gram negative enterobacter such as MCR-1 escherichia coli, klebsiella pneumoniae and salmonella and the like; and establishment of a mouse pneumonia infection model proves that the combination of parthenolide and polymyxin has a good treatment effect on infection of MCR-1 positive bacteria. Therefore, parthenolide is an effective MCR-1 drug-resistant enzyme inhibitor, and has a good experimental therapeutic effect on infection with MCR-1 drug-resistant bacteria when being combined with polymyxin.

Description

technical field [0001] The invention discloses a new application of parthenolide, further relates to the medical application of parthenolide in the preparation of MCR-1 enzyme inhibitors, and belongs to the technical field of medical pharmacy. Background technique [0002] Existing antibiotics cannot effectively treat infections caused by multidrug-resistant Gram-negative bacteria. In addition, the development cycle of new antibiotics is long and very difficult. Colistin is used as the last resort in the treatment of Gram-negative "super bacteria" infections. first-line drugs. At present, the irrational use of broad-spectrum antibiotics has led to increased bacterial resistance to them, and the emergence of the plasmid-mediated colistin resistance gene mcr-1 (encoding the colistin-mediated protease MCR) has a significant impact on multidrug resistance. Serious infections of drug-resistant Enterobacteriaceae pose a great clinical threat. Therefore, it is urgent to find a ne...

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