69 results about "Viricidal activity" patented technology

Non-flammable, VOC-free organosilane quaternary ammonium compositions are provided in the form of pure or substantially pure water-soluble products that have bactericidal, fungicidal and viricidal activity and which are capable of bonding to various surfaces to form durable hydrophobic coatings. The resulting compositions are free of unreacted chloropropyltrialkoxysilanes, alkylamines and organic solvents that would otherwise provide flammable, corrosive, and / or toxic properties thereby inhibiting their safe and effective use in surface care, personal care and coating products.

The present invention is directed to the treatment and prevention of nosocomial infections or MRSA infections utilizing soluble chitosan or chitosan derivative compounds. These chitosan-derivative compounds, e.g., chitosan-arginine and chitosan-acid amines, exhibit bactericidal activity against bacterial pathogens, e.g., drug resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA).

The invention relates to a fatty acid composition, which is diluted at normal temperature and in cold water to form solution used for cleaning of sterilization, fungicide and antivirus. The fatty acid composition comprises at least the following components: component A: food fatty acid comprising at least octyl decanoic acid and nonanoic acid; component B: surfactant comprising alkane sulfonate; component C: acid. The fatty acid composition has the advantages that the fatty acid composition or the diluted solution thereof has good stability, bactericidal and antiviral activity under the water temperature of 4-20 DEG C, no phase separation or crystallization, thus having safer use performance, and active components are low in cost, having more broad-spectrum bactericidal activity which can kill various bacteria, epiphytes and viruses. The fatty acid composition or the diluted solution thereof can be used for sterilization, fungicide and antivirus, which has high-efficient and quick killing effect; the sterilizing rate can reach more than 99.999 percent with contact time less than 1 minute; The fatty acid composition or the diluted solution thereof also has strong cleaning ability, and can keep effective even in hard water; the killing ratio for poliovirus reaches 99.9999 percent and the poliovirus can be killed immediately.

Disclosed herein are an anti-bacterial, anti-fungal and anti-viral composition with excellent sterilizing power, deodorization and adhesion activity, an application thereof, and a method for preparing the same. The composition with sterilizing activity against bacteria, fungus and virus comprises colloidal silver particles in an amount of from 11 wt % to 15 wt %, titanium dioxide nanoparticles in an amount of from 18 wt % to 25 wt %, a dispersion stabilizer in an amount of from 0.01 wt % to 10 wt %, a binder in an amount of from 0.1 wt % to 4 wt %, and a balance of water in an amount required to form 100 wt %.

The invention relates to a spirooxoindole acylhydrazone derivative and a preparation method thereof, and an application of the spirooxoindole acylhydrazone derivative in the aspects of controlling plant viruses and killing bacteria and pests. The spirooxoindole acylhydrazone derivative has a formula with groups defined in the specification. The spirooxoindole acylhydrazone derivative provided by the invention shows excellent plant-virus resisting activity and has broad-spectrum bactericidal and pesticidal activities.

The invention belongs to the field of biotechnology, and particularly relates to an endolysin derived from the Vibrio parahaemolyticus phage, and application of the endolysin. The endolysin is derived from the Vibrio parahaemolyticus phage of which the amino acid sequence is all or a part of the shown amino acid sequence SEQ ID No: 1. Sequence analysis shows that the endolysin is a lyase in the phase, and the lyase enables a bacterial cell wall to be cracked; test confirms that protein formed from the amino acid sequence is better in bactericidal activity. The endolysin has an obvious bactericidal effect on in vitro Vibrio parahaemolyticus after being expressed and purified by a suitable expression vector existing in the market, and can be applied to preparation of a Vibrio parahaemolyticus bacteriostat.

Non-flammable, VOC-free organosilane quaternary ammonium compositions are provided in the form of pure or substantially pure water-soluble products that have bactericidal, fungicidal and viricidal activity and which are capable of bonding to various surfaces to form durable hydrophobic coatings. The resulting compositions are free of unreacted chloropropyltrialkoxysilanes, alkylamines and organic solvents that would otherwise provide flammable, corrosive, and / or toxic properties thereby inhibiting their safe and effective use in surface care, personal care and coating products.

The invention relates to gossypol derivatives and preparation method thereof and application of the gossypol derivatives in plant virus prevention and control, insecticidal action, bactericidal action and anti-cancer action, wherein the significance of all groups in a formula is shown in the description. The gossypol derivatives show the excellent anti-plant virus activity, bactericidal activity, insecticidal activity and anti-cancer activity.

The present invention relates to a compound containing 4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-( trifluomethyl) pyrrol-3-formonitrile and one or several kinds selected from pyrazole, imidazole, triazole, pyrimidine amine and thiocarbamate, etc. Said invention can effectively be used for preventing and controlling the injurious insects, mites and diseases of cotton, fruit tree, tea, vegetable,flower and crops, etc.

The invention relates to a tetrahydroaza [4,5-b] indolylhydrazone derivative as well as a preparation method and application thereof to prevention and control of plant virtuses, sterilization and disinsection, and the meaning of each group in a general formula is shown as a specification. The tetrahydroaza [4,5-b] indolylhydrazone derivative disclosed by the invention has excellent anti-plant-virus activity and further has broad-spectrum bactericidal activity and insecticidal activity.

The invention discloses phage lytic enzymes as well as a gene recombinant expression vector and application thereof. The phage lytic enzyme expression gene is a nucleotide sequence shown as SEQ ID NO:1, and the nucleotide sequence can express phage lytic enzymes in a host cell by constructing a recombinant vector. The phage lytic enzymes obtained through purification have relatively high in-vitroand in-vivo bactericidal activity, acts quickly, is safe and harmless to organisms, can well treat multi-drug-resistance shigella infection, and also has a certain inhibition effect on staphylococcusaureus, vibrio parahaemolyticus and other pathogenic bacteria. The phage lytic enzymes have good lytic thallus activity within the range of 28-42 DEG C, and due to the characteristics, the phage lytic enzymes have a wide prospect in the aspect of preparing drug-resistant infectious disease medicaments and can be used as a substitute or supplement of conventional antibiotics.

The invention belongs to the technical field of biology and particularly relates to endolysin sourced from salmonella bacteriophage and an application thereof. The amino acid sequence of the endolysin sourced from the salmonella bacteriophage includes the total of the partial of the amino acid sequence represented as the SEQ ID No.1. Sequence structure analysis proves that the protease is a lyase which can lysing bacterial cell walls in the bacteriophage. A test proves that the protein formed by the amino acid sequence is good in bactericidal activity. The endolysin, when being expressed and purified by a suitable expression vector on market, can achieve a significant sterilization effect, so that the endolysin can be used for preparing a bacterial inhibitor of salmonella.

The invention provides a 3,4(6)-disubstituted-1,3-benzoxazine-2-ketone compound shown in a formula (I). In the formula (I), when a substituent group R1 is -CH3 and a substituent group R2 is H, R3 is H, or 3-CH3, or 4-CH3, or 2-OCH3, or 4-Cl; when the substituent group R1 is H and the substituent group R2 is -CH3, R3 is 3-CH3, or 4-CH3, 2-OCH3, or 3-OCH3, or 4-Cl. The 3,4(6)-disubstituted-1,3-benzoxazine-2-ketone compound has good bactericidal activity on pathogenic bacteria of crops. The formula (I) is described in the specification.

The invention relates to a glycosyl substituted genipin derivative (I) as well as a preparation method and an application as pesticides. The inhibition rate of a part of compounds in formulae (Ia andIb) to tobacco mosaic viruses exceeds that of commercial variety virazole, and is approximate to that of ningnanmycin. In addition, a part of the compounds in the formulae (Ia and Ib) have excellent sterilization activity on 14 plant pathogens, and fungus bacteriosis of multiple crops can be effectively prevented and treated. A part of the compounds in the formulae (Ia and Ib) have excellent insecticide activity on 4 common lepidoptera pests (plutella xylostella, oriental armyworm, ostrinia nubilalis and cotton bollworm), and lepidoptera pests of multiple crops can be effectively prevented andtreated. Specific synthesis steps and bioactivity are shown in the specification.

Antibacterial compositions effective against both gram positive and gram negative vegetative bacteria plus harmful gram positive sporeforming bacteria include propionibacterial metabolites in combination with two or more of the following: a lantibiotic; a lytic enzyme; and an organic acid or its salt. Methods of use are provided, as well as food products treated with these antibacterial compositions.

The invention provides a novel group of antibacterial peptide, which has stronger bactericidal activity than the natural antibacterial peptide and good bactericidal effect on various pathogenic bacteria. The invention further discloses a preparation method of the group of antibacterial peptide, which can be synthesized in a solid phase chemical method, and also can be obtained by genetic engineering expression. The antibacterial peptide synthesized by the invention can be used for preparing medicaments for curing diseases caused by gram-positive bacteria, gram-negative bacteria or fungal infection.

The invention provides a novel antimicrobial peptide MP1102 of anti-drug resistance staphylococcus aureus, which has strong bactericidal activity on the staphylococcus aureus including MRSA. An encoding gene of the antimicrobial peptide MP1102 is optimized to create a pPICZalphaA-MP1102 recombinant expression vector, pichia pastoris X-33 is linearly converted by BglII to obtain recombinant yeast strain M5 with high level expression of MP1102 so as to realize the high level secretory expression of MP1102 in the pichia pastoris X-33 and create an M5 transformant high density fermentation system, and as shown in detection results of total protein concentration, antimicrobial peptide MP1102 concentration and biomass, the total protein concentration reaches 809mg / L after being fermented at 25 DEG C for 120 hours, the antimicrobial peptide MP1102 concentration reaches 420mg / L, the antimicrobial peptide MP1102 accounts for 52% of the total protein, and the biomass reaches 353g / L. The MP1102 has the potential of being developed as a new generation of antibacterial agents.

The invention discloses a preparation method of a derivative of a natural product Streptochlorin. The invention also discloses an application of the natural product Streptochlorin and the derivative thereof in killing pathogenic bacteria of crops. The natural product Streptochlorin and the derivative thereof have the advantages that the bactericidal activity is good, can be applied to crop diseases caused by fungi, bacteria and viruses, and show efficient and / or broad-spectrum bactericidal activity.

The invention relates to a spirooxoindole (thio)hydantoin derivative as well as a preparation method and application thereof to aspects of plant virus prevention and control, sterilization and insect killing. A structural formula of the derivative is a structure shown as a general formula I. The spirooxoindole (thio)hydantoin derivative provided by the invention has excellent plant virus resisting activity and also has broad-spectrum sterilization activity and insect killing activity. (The formula I is shown in the description.).

The invention relates to a composition for killing harmful fungus, such as sigatoka disease and the like. The composition is characterized in that the composition contains two types of active components: epoxiconazole (chemical name: (2RS,3RS)-1-(3-(2-chlorphenyl)-2, 3-epoxy-2(4-fluorophenyl)propyl)-1-H-1, 2, 4-triazole) and carbendazim (chemical name: benzimidazole-2-benzimidazole methyl carbamate), and the weight ratio between the epoxiconazole and the carbendazim is between 1:0.01 to 1:95. The composition overcomes the defects existing in the prior art, has the extremely remarkable synergistic action, can control the sigatoka disease and other harmful fungi by applying smaller dosage and can display extremely strong bacteria resistance and bactericidal activity.

The invention relates to compounds represented by the formula, and preparation and application thereof in pesticide. The invention provides a novel structure that can inhibit tobacco mosaic virus andkill bacteria and pests. The industrialization is easy and the synthesis is simple. N-substituted-11-substitited matrine derivatives have a good performance on inhibiting the activity of tobacco mosaic virus (protection, treatment, and passivation), and the definition of R is represented in the description.

The invention provides honokiol and application of magnolol in preparation of an MCR-1 enzyme inhibitor, provides honokiol and novel medical application of magnolol in preparation of an MCR-1 enzyme inhibitor and discloses honokiol and magnolo which can inhibit the activity of an MCR-1 enzyme and restore the sterilization activity of polymyxin to MCR-1 enteric bacilli. In an in-vivo experiment, the honokiol and magnolol are combined and applied to bacterial infection of the polymyxin for MCR-1 expression, particularly have a good treatment effect on infection caused by MCR-1 positive enteric bacilli and have a wide medical application range.

The invention discloses a series of substituted azacytanthrin derivatives and application of the compounds as fungicides for preventing and controlling phytopathogen bacteria and fungi and plant virus resisting preparations, the general formula of the derivatives is shown in (I), and the definition of each substituent is detailed in the specification. The compound shown in the general formula has high bactericidal activity and plant virus resistance activity on phytopathogen bacteria such as rice bacterial blight and fungi such as rice blast, and can be used for preparing agricultural special-effect bactericides and tobacco mosaic virus resistance preparations.

The present invention provides a group of new antibacterial peptides which has stronger bactericidal activity than that of natural antibacterial peptides and has good killing effect on various pathogenic bacteria. The present invention also discloses a method for preparing the antibacterial polypeptides which can be synthesized by a solid phase chemical method or obtained through expression by a genetic engineering method. The synthesized antibacterial peptides of the present invention can be used for preparing medicines for treating diseases caused by the infection of gram-positive bacteria,gram-negative bacteria or fungi.

The invention provides a novel group of antibacterial peptide, which has stronger bactericidal activity than the natural antibacterial peptide and good bactericidal effect on various pathogenic bacteria. The invention further discloses a preparation method of the group of antibacterial peptide, which can be synthesized in a solid phase chemical method, and also can be obtained by genetic engineering expression. The antibacterial peptide synthesized by the invention can be used for preparing medicaments for cuing diseases caused by gram-positive bacteria, gram-negative bacteria or fungal infection.

The invention provides a novel group of antibacterial peptide, which has stronger bactericidal activity than the natural antibacterial peptide and good bactericidal effect on various pathogenic bacteria. The invention further discloses a preparation method of the group of antibacterial peptide, which can be synthesized in a solid phase chemical method, and also can be obtained by genetic engineering expression. The antibacterial peptide synthesized by the invention can be used for preparing medicaments for cuing diseases caused by gram-positive bacteria, gram-negative bacteria or fungal infection.

Non-flammable, VOC-free organosilane quaternary ammonium compositions are provided in the form of pure or substantially pure water-soluble products that have bactericidal, fungicidal and viricidal activity and which are capable of bonding to various surfaces to form durable hydrophobic coatings. The resulting compositions are free of unreacted chloropropyltrialkoxysilanes, alkylamines and organic solvents that would otherwise provide flammable, corrosive, and / or toxic properties thereby inhibiting their safe and effective use in surface care, personal care and coating products.

A detoxified recombinant E. coli heat-labile enterotoxin mutant, LTS61K, is employed as a carrier protein to conjugate polysaccharide. The LTS61K contains a mutated mature sub-unit A (LTA) that includes lysine at amino acid position 61 and a wild-type mature sub-unit B (LTB). Various types of bacterial capsular polysaccharide antigens were chemically conjugated with the LTS61K protein by a reductive amination reaction. The conjugated polysaccharide-LTS61K products were physically, chemically and biochemically identified as soluble form. Rabbits were immunized intramuscularly to determine the immunogenicity of conjugated vaccines by ELISA to detect anti- polysaccharide antigen IgG titers and serum bactericidal assay thereby determining the functional activity of the antibodies.; Study results show that conjugated polysaccharide-LTS61K vaccines induce higher polysaccharide-specific IgG titers and greater bactericidal activity in sera than that of polysaccharide alone or polysaccharide mixed with LTS61K. The presence of anti-LTS61K serum IgG antibody alleviates travel diarrhea caused by E. coli (ETEC enterotoxigenic E. coli).

A substituent thieno [3', 2':5,6] pyrido [4,3-d] pyrimidine-4(3H)-one with bactericiding activity and its preparing process is also disclosed. It can be used as the bactericide with high suppression activity to cotton wilt fungus, the sheath and culm blight bacteria of rice, gray mold of cucumber, etc.

The invention discloses a bacillus cereus bacterial strain MA23. The bacillus cereus bacterial strain MA23 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and thepreservation number is CGMCC No.16015. The invention further discloses an inoculant prepared from the MA23 bacterial strain and the preparation and application of the inoculant. The bacillus cereus MA23 can be used for preventing and treating agricultural plant diseases and has efficient and broad-spectrum bactericidal activity.