Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compounds having heat shock heat protein 70 inhibitory activity and applications thereof

A heat shock protein and inhibitory activity technology, applied in the field of compounds with heat shock protein 70 inhibitory activity, can solve the problem of weak GSH reaction performance, etc., and achieve the effect of low side effects and high activity

Active Publication Date: 2022-05-17
PEKING UNIV SHENZHEN GRADUATE SCHOOL
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PES can selectively kill tumor cells, but has no toxicity to normal cells at the same concentration, and can inhibit the activity of tumor cells such as leukemia, lymphoma, bladder cancer, pancreatic cancer, non-small cell lung cancer, and cervical cancer. Glutathione (GSH), which exists in large quantities in the body, also has strong responsiveness, so it is necessary to develop inhibitors that have weak responsiveness to GSH and maintain or improve the binding ability to Hsp70, so as to improve the activity of compounds in complex biological systems and reduce possible side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compounds having heat shock heat protein 70 inhibitory activity and applications thereof
  • Compounds having heat shock heat protein 70 inhibitory activity and applications thereof
  • Compounds having heat shock heat protein 70 inhibitory activity and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A compound with heat shock protein 70 inhibitory activity, the chemical structural formula of the compound is as follows:

[0022]

[0023] The compound of this example is prepared by the route of the above reaction formula.

Embodiment 2

[0025] A compound with heat shock protein 70 inhibitory activity, the chemical structural formula of the compound is as follows:

[0026]

[0027] The compound of this example is prepared by the route of the above reaction formula.

Embodiment 3

[0029] A compound with heat shock protein 70 inhibitory activity, the chemical structural formula of the compound is as follows:

[0030]

[0031] The compound of this example is prepared by the route of the above reaction formula.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine, and specifically provides compounds with heat shock protein 70 inhibitory activity and applications thereof. The compound includes at least one of the three compounds in the specification. The compound of the present invention has weak response ability to glutathione and strong binding ability to heat shock protein 70, and has high activity and low side effect in complex biological system, so it can be used as an inhibitor.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a compound with heat shock protein 70 inhibitory activity and application thereof. Background technique [0002] Heat shock protein 70 (Hsp70) is widely distributed in various organisms, and its sequence and structure are highly conserved from lower bacteria to higher mammals. Hsp70 consists of an amino-terminal nucleotide-binding domain, a carboxy-terminal substrate-binding domain (SBD), and a hydrophobic flexible chain of about ten amino acid residues connecting between the nucleotide-binding domain and the substrate-binding domain. Among them, the substrate-binding domain (SBD) can be further divided into β-sheet-rich SBDβ subdomain and α-helix-rich SBDα subdomain. [0003] There are literature reports, (PES) is an inhibitor of Hsp70 and is thought to possibly bind to the SBD of Hsp70. PES can selectively kill tumor cells, but has no toxicity to normal cells at the same c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D213/34C07D295/26C07C311/13A61P35/00A61K31/4406A61K31/40A61K31/18
CPCC07D213/34C07D295/26C07C311/13A61P35/00Y02A50/30
Inventor 潘峥婴杨杰
Owner PEKING UNIV SHENZHEN GRADUATE SCHOOL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com