Medicament for treating atherosclerosis and application of Sirt6

A technology for atherosclerosis and medicament, which can be applied to medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, which can solve the problems of death and disability of patients.

Active Publication Date: 2021-08-10
华中科技大学同济医学院附属梨园医院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its induced complications can kill or disable the patient

Method used

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  • Medicament for treating atherosclerosis and application of Sirt6
  • Medicament for treating atherosclerosis and application of Sirt6
  • Medicament for treating atherosclerosis and application of Sirt6

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Embodiment Construction

[0030] The principles and features of the present invention are described below in conjunction with the accompanying drawings, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.

[0031] 1. Subendothelial lipid deposition and related molecular levels in GDM patients

[0032] The umbilical cord tissues of patients with gestational diabetes mellitus (GDM) and non-diabetic patients during pregnancy were collected, and the subendothelial lipid deposition was detected by oil red O staining of the umbilical cords.

[0033] The result is as figure 1 As shown, those with GDM showed larger areas of lipid deposition compared with those without GDM, suggesting that high glucose in the body promotes LDL deposition under the endothelium.

[0034] The acetylation levels of lysine 9 (H3K9) and lysine 56 (H3K56) of histone 3 in umbilical cord tissues of GDM patients were detected by immunohistochemical stai...

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Abstract

The invention relates to an application of Sirt6 in regulating cell autophagy. The invention further relates to application of the Sirt6 in preparation of a medicament for treating atherosclerosis caused by diabetes. The invention also relates to a medicament for treating atherosclerosis caused by diabetes. The medicament comprises an expression vector with a Sirt6 gene overexpression cassette. According to the application, the influence of the Sirt6 on the deacetylation of the Caveolin-1 protein in the vascular endothelial cells is found for the first time, and the condition that the deacetylation level of the Caveolin-1 protein in the vascular endothelial cells can be changed by adjusting the expression quantity of the Sirt6, so that the autophagy effect and the atherosclerosis process in the cells are influenced is found. Therefore, the invention has important significance and enlightenment for treating atherosclerosis caused by diabetes.

Description

technical field [0001] The present invention relates to the field of treating atherosclerosis caused by diabetes, more particularly, relates to the application of Sirt6 in treating atherosclerosis caused by diabetes. Background technique [0002] Type 2 diabetes is one of the most common age-related chronic diseases, with a high incidence both domestically and globally. Generally speaking, people with diabetes are not life-threatening. However, its induced complications can lead to death or disability of patients. For example, atherosclerotic cardiovascular disease is the leading cause of death and disability in patients with type 2 diabetes. [0003] The mechanism by which diabetes accelerates the formation of atherosclerosis (AS) is unclear, and the "lipid-retention" response hypothesis has received extensive attention in the current research on AS. In this hypothesis, the process of low-density lipoprotein LDL passing through vascular endothelial cells and depositing u...

Claims

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Application Information

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IPC IPC(8): A61K38/50A61P9/10A61P3/10
CPCA61K38/50C12Y305/01098A61P9/10A61P3/10
Inventor金肆赵颖贾雄
Owner华中科技大学同济医学院附属梨园医院