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Reagent compositions and method for karl fischer titration

A kind of technology of composition and reagent, applied in measuring the amount of water in a sample, the application field of imidazole derivative and amino acid in this reagent composition

Pending Publication Date: 2021-10-29
HONEYWELL INT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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However, toxicity concerns remain

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  • Reagent compositions and method for karl fischer titration
  • Reagent compositions and method for karl fischer titration
  • Reagent compositions and method for karl fischer titration

Examples

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Embodiment

[0074] A series of titrations were performed according to the present disclosure and as a comparative example using a two-component system. The result is shown below.

[0075] In a first series of examples, repeated titrations of Hydranal Water Standard 10.0, No. 34849 with 10 mg / g water were done. The base used is 2-ethylimidazole. The alcohol used was ethanol. 10 individual titrations were performed for the comparative example not containing any amino acid. 10 separate titrations were also carried out for the examples of the invention comprising 0.23% by weight of proline as an amino acid. Standard deviations were then calculated for both the comparative examples and the inventive examples. As shown below, the standard deviations of the inventive examples are surprisingly better than those of the comparative examples. A Metrohm Titrando 888 with KF equipment was utilized as known in the art. The titration type is volumetric. SO that exists 2 The amount is about 8% (w...

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Abstract

A reagent composition for a Karl Fischer titration, disclosed by the present invention, includes (1) sulfur dioxide or a derivative thereof, (2) a derivative of imidazole, (3) an alcohol, and (4) at least one amino acid that is present in an amount that is greater than zero and up to about 10 weight percent based on a total weight of the reagent composition. Moreover, a molar ratio of the derivative of imidazole to the sulfur dioxide or derivative thereof is greater than 1:1. Iodine is optionally included in a one-component reagent and excluded in a two-component reagent. The disclosure further provides a method for determining an amount of water in a sample via Karl Fischer titration. The method includes the step of providing the sample, providing the reagent composition which optionally includes the iodine (I2), and titrating the sample with the reagent composition.

Description

technical field [0001] The present disclosure generally relates to one-component and two-component reagent compositions for Karl Fischer titration and methods of using these reagent compositions to determine the amount of water in a sample. The present disclosure relates more particularly to the use of imidazole derivatives and amino acids in such reagent compositions. Background technique [0002] The determination of moisture according to the Karl Fischer method (i.e. by Karl Fischer titration) utilizes the following reaction: [0003] (1) SO 2 +ROH+B→BHSO 3 R; [0004] (2)BHSO 3 R+I 2 +H 2 O+2B→BHSO 4 R+2BH; [0005] (3) SO 2 +I 2 +H 2 O+3B→BSO 3 +2BHI; [0006] (4)BSO 3 +H 2 O+B→BHSO 4 +BH [0007] where B is a base and ROH is an alcohol. The titration method is performed in two basic forms, namely: volumetric titration and coulometric titration. [0008] In a typical Karl Fischer titration, the reagents contain alkyl sulfites, which are oxidized in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N31/16
CPCC01B17/48C07D233/56C07D207/16G01N31/168
Inventor S·西坎普M·科诺帕茨基
Owner HONEYWELL INT INC
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