45 results about "Disulfur dioxide" patented technology

The invention provides a preparation method of 1, 3-propane sultone, which comprises the following steps: introducing an allyl alcohol aqueous solution, a sodium hydroxide aqueous solution, sulfur dioxide and a slow-release peroxide into a continuous fluid reactor, reacting to obtain a 3-hydroxy propane sodium sulfonate crude product, acidifying the crude product to obtain 3-hydroxy propane sulfonic acid, concentrating to remove water, separating out salt by using methanol, and filtering to obtain 1, 3-propane sultone. And finally carrying out reduced pressure distillation on the filtrate to obtain 1, 3-PS. The slow-release peroxide is used for replacing conventional hydrogen peroxide or benzoyl peroxide to serve as an initiator, the preparation process conditions of the slow-release peroxide are controlled, calcium peroxide is embedded through stearic acid firstly, then surface modification polydopamine is subjected to secondary embedding, and the slow-release peroxide of a special structure is obtained; the selectivity of the 3-hydroxypropane sodium sulfonate is obviously improved while the reaction efficiency is not excessively influenced, and the method has industrial advantages.

The present application relates to a kind of catalyst for preparing ethylene sulfite, the preparation method of ethylene sulfite, the catalyst includes organic aluminum compound and amine, the molar ratio of the organic aluminum compound and the amine is 1-5:1.The preparation method of ethylene sulfite includes the reaction of contacting ethylene oxide with sulfur dioxide in the presence of the catalyst.The quaternary ammonium salt in the catalyst of the present application and trialkylaluminum are excited by phase transfer and coordination, etc.Effect, monomer ring-opening of ethylene oxide, promote SO2 and ethylene oxide to react to generate ethylene sulfite, and then high-purity ethylene sulfite is prepared with high yield.

The invention belongs to the field of chemical reagent moisture detection, and particularly relates to a coulometry Karl Fischer reagent for aldehyde ketone moisture detection and a preparation method of the coulometry Karl Fischer reagent. The coulometry Karl Fischer reagent for aldehyde ketone moisture detection is prepared from the following components in parts by weight: 1 to 15 percent of imidazole, 1 to 15 percent of 2-methylimidazole, 25 to 70 percent of ethylene glycol monomethyl ether, 5 to 30 percent of trichloromethane, 2 to 30 percent of trifluoroethanol, 2 to 10 percent of sulfur dioxide, 1 to 10 percent of methyl iodide, 0.1 to 5 percent of tetrabutylammonium iodide and 0.1 to 5 percent of iodine. The method does not contain hydroxyl compounds, effectively inhibits the generation of side reactions in detection, ensures the detection accuracy, and improves the product stability and effectively shortens the instrument equilibrium time by adding iodomethane and tetrabutylammonium iodide.

The application belongs to the technical field of chondroitin sulfate preparation, and particularly relates to application and application method of liquid sulfur dioxide in preparation of chondroitin sulfate or chondroitin sulfate salt. In the application, liquid sulfur dioxide is used as a solvent to perform sulfonation modification treatment on unsulfated chondroitin, on the one hand, the use of traditional high-boiling organic reagents is avoided, the difficulty of three-waste treatment is reduced, and the process is more green and environmentally friendly; on the other hand, the post-treatment operation of the sulfonation reaction is simpler, and sulfur dioxide can be removed from the system by only temperature control or pressure adjustment, so that solvent residues possibly existing in the final product are avoided, and the product is safer. In addition, by adjusting the key conditions of the sulfonation reaction, the proportion of chondroitin sulfate with 6 independent sulfation in the disaccharide unit of the sulfonation product is 70% to 90%, the reaction is stable and reliable, and the sulfonation rate is high.

The invention provides a method and a device for measuring the purity of a medicine for seawater desalination, and the method comprises the following steps: titrating a sodium hypochlorite sample by using a first reducing agent, detecting the change of a platinum electrode in the process, reading the consumption of the first reducing agent when the sodium hypochlorite sample is in redox equilibrium, and calculating the concentration of the first reducing agent; calculating in combination with a formula I to obtain the available chlorine concentration in the sodium hypochlorite sample; titrating the sodium hydrogen sulfite sample by using a second reducing agent, detecting the change of the platinum electrode in the process, reading the consumption of the second reducing agent when the sodium hydrogen sulfite sample is in redox equilibrium, and calculating by combining a formula II to obtain the mass fraction of sulfur dioxide in the sodium hydrogen sulfite sample. According to the present invention, by using the redox titration principle, the mark of the titration end point is accurately set and identified so as to solve the problems of poor detection result accuracy, high reagent consumption, low detection efficiency and tedious operation process of the existing manual titration analysis method.

The application provides a novel ratio near-infrared fluorescent probe for detecting sulfur dioxide, a preparation method and application of the fluorescent probe, the fluorescent probe is Cou-Oxo, the preparation method comprises the following steps: dissolving a compound Cou-CN and a compound 3 in toluene, adding piperidine to catalyze a reaction, refluxing at 114-116 DEG C under a nitrogen atmosphere for 4.8-5.2 hours, and after the reaction is completed, the fluorescent probe Cou-Oxo is obtained through purification.The ratio fluorescent probe has good light emitting characteristics, can effectively detect sulfur dioxide derivatives, has the potential of quantitative detection, and the lower limit of detection is 0.942 muM.The ratio fluorescent probe has a fast response to the detection of sulfur dioxide derivatives, has good light emitting characteristics and stability, and can detect HSO3 ‑ in a physiological pH range of 7-9; the ratio fluorescent probe has lower biological toxicity and is suitable for cell imaging.

The synthesis method comprises the following steps: adding a methylthio phenyl alkynone compound as shown in a formula (I), 2-bromo-2, 2-difluoro-N-aryl acetamide as shown in a formula (II) and DABSO as shown in a formula (III) into a reaction solvent, carrying out stirring reaction under the conditions of nitrogen protection and illumination, and carrying out filtering, washing and drying, thereby obtaining the methylsulfonyl thioflavone derivative as shown in the formula (I). The synthesis method comprises the following steps: adding a methylthio phenyl alkynone compound as shown in the formula (I), 2-bromo-2, 2-difluoro-N-aryl acetamide as shown in the formula (II) and DABSO as shown in the formula (III) into the reaction solvent; after the reaction is finished, the reaction liquid is subjected to post-treatment to obtain a target compound, namely the methylsulfonyl-containing thioflavone derivative with the anti-tumor activity, shown as a formula (IV), the reaction equation is # imgabs0, and DABSO is a bis (sulfur dioxide)-1, 4-diazabicyclo [2.2. 2] octane adduct; in the formula (I) and the formula (IV), R is selected from a bromine atom or a pyridine ring; r1 is selected from a cyano group, a halogen group or a thienyl group. The method has the advantages of simple operation process, cheap and easily available raw materials, mild reaction conditions, environmental protection, atom economy and high yield.

The invention discloses a novel phosphoric acid purifier and a preparation method thereof. The novel phosphoric acid purifier comprises the following mass percentages of hydrosulfate 34-40.0%, sodium carbonate 21-24%, sulfate 3%, sulfur dioxide about 1%, and the balance water. A method for preparing a novel phosphoric acid purifier comprises the following steps: step 1: adding a measured amount of sodium thiosulfate to a reactor, heating and dissolving it; step 2: adding a measured amount of catalyst and an organic flocculant to prepare it under a temperature of 60°C-80°C. Sodium thiosulfate is used to replace sodium sulfide, sodium thiosulfate is used as a basic raw material, sodium thiosulfate is modified, and a suitable catalyst is added to increase the decomposition rate of S2-, so as to reduce the arsenic ions in a high arsenic-containing phosphoric acid solution from 60ppm to below 0.5ppm, thereby achieving the purpose of phosphoric acid dearsenicization.

The application discloses a method for continuously preparing high-purity sulfolane, and belongs to the technical field of organic synthesis. By introducing a solvent and a stable free radical type polymerization inhibitor, the self-polymerization of butadiene is effectively inhibited. By adopting a cooling crystallization mode to remove sulfur dioxide, the thermal decomposition of sulfolene sulfone is avoided, high yield and high purity are realized, the service life of a hydrogenation catalyst is not affected, and the catalyst can be completely reused. The cooling crystallization also realizes the separation of the polymerization inhibitor and sulfolene sulfone. The polymerization inhibitor is dissolved in the solvent and recycled, and does not enter the hydrogenation system, so that the final sulfolane product has a purity of above 99.9% and has no chromaticity problem. The process saves energy consumption, the solvent has wide universality, operation is simple, the process is safe and environment-friendly, easy to scale up, and meets the green production requirements.

The invention relates to a method for manufacturing sulphuric acid, which involves converting sulphur dioxide SO2 into sulphur trioxide SO3, by injecting gaseous sulphur dioxide into a converter (1) inside which at least one mass (2) of a catalyst for the conversion is present, and according to which, during phases in which the injection of the gaseous sulphur dioxide is stopped, the space inside the converter (1) is heated in such a way as to maintain a minimum temperature of 200° C., and preferably 250° C., within each catalyst mass (2), characterized by the fact that the stopping of the injection of the sulphur dioxide is slaved to the starting of the heating, and vice versa.

The invention discloses a preparation method of light-mediated aryl / heteroaryl sulfonamide and derivatives thereof, the reaction route is shown in the following formula, and the reaction comprises the following steps: (1) under the irradiation of blue light, reacting carboxylic acid active ester shown in the formula I with a sulfur dioxide source under the catalysis of a photocatalyst; and (2) acidifying the reaction product obtained in the step (1) to obtain the aryl / heteroaryl sulfonamide product as shown in the formula II. The method for catalyzing the reaction of the carboxylic acid active ester and the sulfur dioxide source under the action of the photocatalyst and the blue light to obtain the corresponding sulfonamide derivative has the advantages of simple reaction process operation, mild reaction conditions, recoverable raw materials, strong compatibility and adaptability, and wide substrate range and universality. # imgabs0 #

A method can include: introducing sulfur dioxide in an anolyte flow path of an electrolyzer; optionally, introducing water in the catholyte flow path of the electrolyzer; operating the electrolyzer; optionally: processing the products; and optionally: using the products. In some variants of the method, the amount of water introduced can be balanced such as to achieve a target sulfuric acid concentration.

The invention belongs to the technical field of fluorescent probes, and particularly discloses a fluorescent probe capable of detecting sulfur dioxide derivatives and viscosity. The invention also discloses a synthesis method of the fluorescent probe. The fluorescent probe provided by the invention has the advantages of simple synthesis route, mild reaction conditions, simple and convenient post-treatment, good selectivity, high sensitivity and the like, and can be used for dual detection of in-vivo and in-vitro SO2 derivatives and viscosity.

The invention provides a Karl-Fischer reagent for anisole moisture detection and a preparation method thereof, and the Karl-Fischer reagent comprises the following components by mass: 2-6% of iodine, 8-12% of sulfur dioxide, 70-80% of an ether solvent, and 10-20% of an alkaline buffer agent. The solvent of the Karl Fischer reagent is an ether solvent, and an alkaline buffer agent is added, so that interference of peroxide in anisole can be effectively avoided, and the accuracy of anisole moisture detection is ensured; moreover, the Karl Fischer reagent does not contain toxic and environment-polluting components such as methanol, pyridine and the like, and is safer and more environment-friendly.

The utility model belongs to the technical field of sulfuryl fluoride preparation equipment, and particularly relates to a reactor for preparing sulfuryl fluoride, which comprises a bottom frame, an outer barrel fixedly connected to the top of the bottom frame, a reaction barrel fixedly connected to the inside of the outer barrel, a bearing fixedly connected to the inner side of the reaction barrel, and a rotating frame fixedly connected to the inner side of the bearing. The rotating shaft drives the inner ring to rotate so as to drive the connecting rods to enable the outer ring to drive the spiral columns to rotate, the spiral columns are rotated by starting the motor, and the upper and lower adjacent spiral columns are arranged in a staggered manner, so that potassium fluoride particles attached to the outer sides of the spiral columns can be in full contact with sulfur dioxide and fluorine gas, and the reaction is more thorough; therefore, the preparation efficiency is improved.

The present application relates to a method for preparing sulfuryl fluoride, the method comprising: (1) providing a reaction stream comprising an organic base-hydrogen fluoride complex; (2) introducing sulfur dioxide and chlorine into the reaction stream comprising the organic base-hydrogen fluoride complex, and reacting to form a product stream comprising sulfuryl fluoride. The method described in the present application has mild reaction conditions, high product yield and purity, material recycling, less waste, etc., and is suitable for industrial production.

The present invention relates to a reducing scale inhibitor and a preparation method thereof, comprising the following components in mass percentages: thiourea dioxide 1-1.5%, sodium bisulfite or sodium metabisulfite 10-15%, urea 3-5%, sodium hexametaphosphate 10-20%, hydrolyzed maleic anhydride 8-10%, oxalic acid 5-10%, and the balance being water. The reducing scale inhibitor of the present invention can significantly reduce the ORP and residual chlorine in wastewater with only a small dosage, and at the same time has a good scale inhibition effect on calcium ions, iron ions, manganese ions, etc. in the wastewater.

A method for preparing cyano sulfonyl fluoride compounds is provided. Oxime ether compounds are used as free radical precursors, and under the condition of photocatalyst regulation, and in combination with the strategy of free radical sulfur dioxide insertion, the process involves photocatalytic oxidation, C—C bond cleavage rings, free radical SO2 insertion and fluorination to achieve cyano / fluorosulfonyl reaction of oxime ether, yielding cyano sulfonyl fluoride products.

The application discloses a synthesis method of a beta-fluorosulfonyl sulfone compound and application thereof, and belongs to the technical field of chemical synthesis and medicinal chemistry. The method comprises the following steps: under a protective atmosphere, potassium trifluoroborate compound, a photocatalyst, a sulfur dioxide source, a hydrogen source and ethylenesulfonyl fluoride are mixed in an organic solvent, and reaction is carried out under light irradiation to obtain the beta-fluorosulfonyl sulfone compound. The application can realize preparation of a series of beta-fluorosulfonyl sulfone compounds, provides a new synthesis method for synthesis of the beta-fluorosulfonyl sulfone compound, and sulfone groups and sulfonyl fluoride groups are part of the structures of various drug molecules, so that the application is expected to be widely applied in the fields of organic synthesis, drug development and polymer materials.

1. The name of the product of this design: packaging box (selenium disulfide lotion). 2. Purpose of this design product: used for outer packaging of sulfur dioxide lotion. 3. The design key point of this appearance design product lies in the combination of pattern and color. 4. The picture or photo that best illustrates the key points of the design: main view. 5. The design for which protection is sought includes color.

The invention relates to the technical field of chemical preparation, in particular to a production method and a production system of sodium sulfite, and discloses a production method of sodium sulfite, which comprises the following steps: introducing tail gas containing sulfur dioxide into the system, and then enabling the tail gas to enter a first-stage falling film absorption tower, a second-stage falling film absorption tower and a third-stage falling film absorption tower; the method comprises the following steps: carrying out circulating absorption by using a sodium hydroxide solution containing ethylene glycol, introducing a sodium sulfite solution into a neutralization kettle by using a primary circulating pump, adding liquid caustic soda to adjust the pH value of the sodium sulfite solution to 8-9, and carrying out reduced pressure concentration on water by using a falling-film evaporator to obtain a high-concentration ethylene glycol suspension containing sodium sulfite, introducing the high-concentration ethylene glycol suspension into a centrifugal machine, and ethylene glycol is recycled and reused, so that a sodium sulfite solid containing a trace amount of ethylene glycol is obtained. The problem that when sodium sulfite is prepared in winter in an existing method, the sodium sulfite solution is prone to crystallization, and consequently pipelines are blocked is solved, and the effects of preventing the sodium sulfite solution from crystallization in winter and avoiding pipeline blocking are achieved.

A process for the production of glycolaldehyde by thermolytic fragmentation of a carbohydrate feedstock including mono- and / or di-saccharide(s) and a system suitable for performing the process. The process and the system are suitable for industrial application, and the process may be performed in a continuous process. The salt-depleted carbohydrate feedstock may include one or more impurities selected from the group of arsenic, lead, sulfate, sulfur dioxide, and 5-(hydroxymethyl)furfural.

The invention discloses a synthesis method of 18F-labeled alkyl sulfonyl fluoride molecules based on hypervalent iodine (III) carboxylate, which comprises the following steps: in a solvent, in the presence of an 18F-fluorination reagent, a sulfur dioxide source and copper salt, carrying out a reaction shown as follows on a compound shown as a formula II to obtain a compound shown as a formula I, namely the 18F-labeled alkyl sulfonyl fluoride molecules # imgabs0, in which R is # imgabs1 # imgabs2 #, R1 is phenyl or cyano, R2 is phenyl or cyano, and R3 is phenyl or cyano; r1 is methyl, methoxy, nitro, methyl formate and bromine; and R2 is phenyl. The problem of limitation of an existing < 18 > F sulfonyl fluoride labeling method is solved, a novel method which is simple in reaction condition, efficient and good in substrate applicability is developed, synthesis of < 18 > F labeled alkyl sulfonyl fluoride is achieved, raw materials are easy to obtain, and operation is easy.

The invention relates to a method for continuously preparing ethylene sulfate, and belongs to the field of organic chemical industry. The method comprises the following steps: firstly, modifying titanium silicalite molecular sieve particles by adopting a silane coupling agent and nano aluminum trifluoride to obtain titanium silicalite molecular sieve particles with a hydrophobic acidic shell as a catalyst, filling the catalyst into a tower reactor, and adding ethylene oxide and sulfur dioxide into a first mixer and a first preheater; feeding into a tower type fixed bed reactor from the tower bottom under a certain pressure, and reacting under the catalysis of a catalyst hydrophobic acidic shell to obtain ethylene sulfite; hydrogen peroxide and chloroform enter the fixed bed tower reactor from the tower top after passing through a second mixer and a second preheater, and are subjected to oxidation reaction with ethylene sulfite to obtain ethylene sulfate. The ethylene sulfate is prepared in a continuous manner, so that the reaction time is shortened, and the production efficiency and the production safety are improved.

The application provides a kind of construction of indole derivative fluorescent probe for detecting viscosity and sulfur dioxide in vivo, and belongs to the field of biological detection.The fluorescent probe (denoted as BIC) of the application utilizes the strong nucleophilicity of sulfur dioxide, and realizes the specificity selection of sulfur dioxide by generating new product BIC-SO2 through Michael addition reaction with double bond in the structure of probe; in addition, benzene ring and indole in BIC structure can freely rotate in low viscosity environment, resulting in non-radiation consumption of excited state energy, showing very weak fluorescence; in high viscosity solution, the free rotation of probe is inhibited, resulting in the recovery and enhancement of probe fluorescence, showing very strong fluorescence. Therefore, the fluorescent probe of the application can simultaneously detect viscosity and sulfur dioxide in vivo.

The invention discloses a method for efficiently preparing methanesulfonic acid from methane, which comprises the following reaction processes: introducing methane, sulfur dioxide and oxygen into a fixed bed reactor filled with a catalyst, and carrying out gas-liquid separation on reaction components to obtain methanesulfonic acid, the catalyst is a supported catalyst comprising an active metal and a carrier; the active metal comprises at least one noble metal selected from palladium, platinum and iridium and at least one other metal selected from vanadium, molybdenum, iron and potassium. The method has the advantages of simple process, high product yield, mild reaction conditions, easiness in industrialization and the like.

The present application relates to a kind of nickel cobalt hydroxide mass promotion method, the present application directly uses sulfur dioxide and air oxidation after removing iron aluminum, manganese in the liquid after removing iron aluminum, directly convert into manganese dioxide and other manganese oxides, remove manganese first, save the cost of continuous reducing agent;After removing manganese, the liquid is treated to form conversion alkali crystal slurry, itself contains little manganese, and the insoluble and non-reactive manganese oxide caused by excessive alkali problem will not be brought, so that the manganese content in nickel cobalt hydroxide product is reduced, and the quality of nickel cobalt hydroxide product is improved.

The present invention relates to an arylsulfonyl fluoride and a preparation method using an aryliodonium salt as a raw material, comprising: mixing the aryliodonium salt, a sulfur dioxide source, a fluorine source, and a photosensitizer in an organic solvent in an inert gas atmosphere, and stirring the mixture for reaction under light conditions to obtain the arylsulfonyl fluoride; wherein the aryliodonium salt has the following structural formula: #imgabs0# wherein R 1 、R 2 wherein the anion X is H, alkyl, halide, methoxy, cyano, or trifluoromethyl, respectively; and the anion X is a hexafluorophosphate anion, a trifluoromethanesulfonate anion, or a p-toluenesulfonate anion, etc. Compared with the prior art, the present invention, based on a novel strategy of "free radical sulfur dioxide insertion fluorination," achieves efficient, metal-free photocatalytic synthesis of arylsulfonyl fluorides at room temperature. This method has the advantages of mild reaction conditions, simple operation, and good yields. It is also highly applicable to both symmetrical and asymmetrical aryliodonium salts, and the gram-scale reaction provides more possibilities for introducing sulfonyl fluoride groups into drug molecules.

The present invention provides a method for determining the water content in a radioactive suspension, comprising: taking the radioactive suspension and determining the mass of the radioactive suspension; adding the radioactive suspension to a Karl Fischer reagent, causing the water in the radioactive suspension to react with the Karl Fischer reagent and oxidizing iodine to iodide ions, wherein the Karl Fischer reagent at least comprises: iodine, sulfur dioxide, and pyridine; subjecting the iodide ions to electrolytic treatment to reduce the iodide ions to iodine and obtaining the amount of electricity consumed when reducing the iodide ions; and calculating the water content in the radioactive suspension according to the mass of the radioactive suspension and the amount of electricity consumed when reducing the iodide ions. The solution of the present invention can quickly and accurately determine the water content in the radioactive suspension.

The invention relates to the technical field of chemical synthesis, and particularly discloses a preparation process of thionyl chloride. Sulfur, chlorine and sulfur dioxide enter a fixed bed to react, mixed gas obtained after the reaction is subjected to two-time sulfur preparation reaction, the content of sulfur dichloride in thionyl chloride is reduced, a composite catalyst is used in the second-time sulfur preparation reaction, decomposition of dichlorosulfuryl is promoted, and the content of dichlorosulfuryl in thionyl chloride is reduced. The thionyl chloride prepared by the method has the advantages of few impurities and high purity.