6 results about "Disulfur dioxide" patented technology

The application belongs to the technical field of chondroitin sulfate preparation, and particularly relates to application and application method of liquid sulfur dioxide in preparation of chondroitin sulfate or chondroitin sulfate salt. In the application, liquid sulfur dioxide is used as a solvent to perform sulfonation modification treatment on unsulfated chondroitin, on the one hand, the use of traditional high-boiling organic reagents is avoided, the difficulty of three-waste treatment is reduced, and the process is more green and environmentally friendly; on the other hand, the post-treatment operation of the sulfonation reaction is simpler, and sulfur dioxide can be removed from the system by only temperature control or pressure adjustment, so that solvent residues possibly existing in the final product are avoided, and the product is safer. In addition, by adjusting the key conditions of the sulfonation reaction, the proportion of chondroitin sulfate with 6 independent sulfation in the disaccharide unit of the sulfonation product is 70% to 90%, the reaction is stable and reliable, and the sulfonation rate is high.

The application discloses a synthesis method of a beta-fluorosulfonyl sulfone compound and application thereof, and belongs to the technical field of chemical synthesis and medicinal chemistry. The method comprises the following steps: under a protective atmosphere, potassium trifluoroborate compound, a photocatalyst, a sulfur dioxide source, a hydrogen source and ethylenesulfonyl fluoride are mixed in an organic solvent, and reaction is carried out under light irradiation to obtain the beta-fluorosulfonyl sulfone compound. The application can realize preparation of a series of beta-fluorosulfonyl sulfone compounds, provides a new synthesis method for synthesis of the beta-fluorosulfonyl sulfone compound, and sulfone groups and sulfonyl fluoride groups are part of the structures of various drug molecules, so that the application is expected to be widely applied in the fields of organic synthesis, drug development and polymer materials.

The application provides a kind of construction of indole derivative fluorescent probe for detecting viscosity and sulfur dioxide in vivo, and belongs to the field of biological detection.The fluorescent probe (denoted as BIC) of the application utilizes the strong nucleophilicity of sulfur dioxide, and realizes the specificity selection of sulfur dioxide by generating new product BIC-SO2 through Michael addition reaction with double bond in the structure of probe; in addition, benzene ring and indole in BIC structure can freely rotate in low viscosity environment, resulting in non-radiation consumption of excited state energy, showing very weak fluorescence; in high viscosity solution, the free rotation of probe is inhibited, resulting in the recovery and enhancement of probe fluorescence, showing very strong fluorescence. Therefore, the fluorescent probe of the application can simultaneously detect viscosity and sulfur dioxide in vivo.

The application provides a method for preparing sulfinic acid compounds, sulfinic acid salt compounds, sulfonic acid salt compounds and sulfonyl compounds through sulfinylation, comprising the following steps: under the conditions of a protective atmosphere and light, performing a sulfinylation reaction on an alkyl compound and a sulfur dioxide donor under the condition of a catalyst to obtain an alkyl sulfinic acid compound. The main catalyst comprises a metal salt, and the metal elements in the metal salt comprise one or more of Fe, Cu and Ce; the cocatalyst comprises one or more of chlorosilane, a tetraalkylammonium chloride, an alkali metal chloride and hydrochloric acid. The method in the application has high catalytic efficiency (TON>350000, TOF>50000 / h), high selectivity (the conversion selectivity of sulfinic acid is >99%), high conversion rate (sulfinic acid is close to complete conversion), and is low in cost, high in atomic economy, basically free of waste in the production process, and green, low-carbon and environmentally friendly.