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Preparation method of luteolin

A technology of luteolin and monohydric alcohol, which is applied in the direction of organic chemistry, can solve the problems of cumbersome process, low yield, and long time-consuming, and achieve the effect of simple process, high yield, and short time-consuming

Active Publication Date: 2020-02-07
BONTAC BIO ENG SHENZHEN +2
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Problems solved by technology

[0004] In view of the above-mentioned deficiencies in the background technology, the purpose of the present invention is to solve the technical problems of the existing methods for preparing luteolin which are cumbersome, time-consuming, low yield and high cost, and provide a simple process, low cost, Semi-synthetic method for preparing luteolin with mild reaction conditions, high efficiency and high yield

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  • Preparation method of luteolin
  • Preparation method of luteolin

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Embodiment Construction

[0035] The present invention will be described in further detail below in conjunction with specific examples. The following examples are explanations of the present invention, and the present invention is not limited to the following examples.

[0036] The raw materials and reagents used in the following examples were purchased from the market unless otherwise specified. The sodium hydrosulfite (sodium dithionite) used in the following examples is purchased from Shanghai Aladdin Biochemical Technology Co., Ltd., and the batch number is LD1826075; the reducing agent used in the following examples is self-made, and the mass ratio of each component is thiourea dioxide : Potassium chloride: Potassium carbonate=9:10:1.

[0037] The following examples all prepare luteolin according to the following process steps, wherein, the step 3) in the embodiment 1 to the embodiment 7 is the above-mentioned self-made reducing agent, and the step 3) in the comparative example 1 and the comparati...

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Abstract

The invention discloses a preparation method of luteolin. The preparation method comprises following steps: fully dissolving rutin in an alkaline solution with a pH of 10 or more; adding a reducing agent composed of thiourea dioxide, potassium chloride, and potassium carbonate into the solution, wherein the ratio of the reducing agent to rutin is 5-24:1, stirring the solution until the solution becomes clear; and controlling the temperature in a range of 60 to 90 DEG C to carry out reactions for 1 to 2 hours to obtain luteolin. The preparation method has the advantages of simple technology, low cost, mild reaction conditions, short production time, and high yield, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of synthesis of pharmaceutical and chemical products, in particular to a semi-synthetic method for preparing luteolin. Background technique [0002] Luteolin is a natural flavonoid compound, named after it was originally isolated from the leaves, stems, and branches of the herb luteolin in the genus luteolin. It is widely distributed in nature and can be obtained from a variety of natural medicinal materials. , Vegetables and fruits isolated. Luteolin has a variety of pharmacological activities, such as anti-inflammatory, anti-allergic, uric acid-lowering, anti-tumor, anti-bacterial, anti-viral, etc. It is mainly used clinically for cough, expectorant, anti-inflammatory, uric acid-lowering, and treatment of amyotrophic lateral sclerosis Syndrome, SARS, hepatitis, cardiovascular and other diseases. [0003] The currently known common preparation methods of luteolin include plant extraction and separation me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40
CPCC07D311/30C07D311/40
Inventor 张琦李振伟韩魁元李冬玲
Owner BONTAC BIO ENG SHENZHEN
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