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Reduced nicotinamideribosides for treatment/prevention of liver disease

A technology of nicotinamide riboside and liver disease, applied in the field of reduced nicotinamide riboside for treating/preventing liver disease

Pending Publication Date: 2021-12-24
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, there is an urgent, unmet need to address liver diseases and / or disorders with new compounds, compositions, and methods of prevention and / or treatment that affect NAD+

Method used

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  • Reduced nicotinamideribosides for treatment/prevention of liver disease
  • Reduced nicotinamideribosides for treatment/prevention of liver disease
  • Reduced nicotinamideribosides for treatment/prevention of liver disease

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Embodiment approach

[0043] The present invention provides compounds and compositions comprising reduced nicotinamide riboside. Another aspect of the invention is a unit dosage form of a composition consisting of reduced nicotinamide riboside and comprising an amount effective to increase intracellular NAD in a subject in need thereof + reduced nicotinamide riboside.

[0044] In the prevention or treatment of liver disease, NAD + An increase in biosynthesis can be provided by an individual such as a human (e.g., a human undergoing medical treatment), a pet or a horse (e.g., a pet or horse undergoing medical treatment), or a cow or poultry (e.g., a cow or poultry used in agriculture). One or more beneficial effects.

[0045] For non-human mammals such as rodents, some embodiments include administering an amount of the composition that provides from 1.0 mg to 1.0 g reduced nicotinamide riboside per kg body weight of the non-human mammal, preferably from 10 mg to 500 mg Reduced nicotinamide ribosi...

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Abstract

The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and / or treatment of liver disease and / or conditions. In one embodiment of the invention, the compounds and compositions of the invention improve liver by: maintaining or improving a liver function; maintaining or improving a hepatocyte function; and improving liver recovery and regeneration after injury, transplantation or surgery. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and / or treat liver diseases and / or conditions such as: non-alcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease, hepatic steatosis, cirrhosis and / or recovery and regeneration after liver injury, transplantation or surgery.

Description

technical field [0001] The present invention provides compounds and compositions comprising reduced nicotinamide riboside for use in methods of preventing and / or treating liver diseases and / or disorders. In one embodiment of the invention, the compounds and compositions of the invention improve the liver by: maintaining or improving liver function; maintaining or improving liver cell function; and improving liver recovery and regeneration after injury, transplantation or surgery . In another embodiment of the present invention, the compounds and compositions of the present invention are useful in methods of preventing and / or treating liver diseases and / or disorders, such as: non-alcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease, Recovery and regeneration after hepatic steatosis, cirrhosis and / or liver injury, transplantation or surgery. Background technique [0002] The liver plays an important role in protein production, blood clotting, cholesterol, glu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P1/16A61P31/22A61P43/00A23L2/00A23L2/52
CPCA61K31/706A61P1/16A61P31/22A61P43/00A23L2/00A23L2/52
Inventor C·坎托阿尔瓦雷斯S·克里斯滕M·P·吉内J·吉鲁-格贝坦特S·莫科M·米高
Owner SOC DES PROD NESTLE SA
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