Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of cobimetinib in preparation of medicine for treating ischemia/reperfusion injury and cell protection medicine

A reperfusion injury, cobimetinib technology, applied in the field of biomedicine, has achieved good application prospects

Active Publication Date: 2022-01-28
CENT SOUTH UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is suitable for advanced melanoma that carries BRAFV600E or V600K gene mutation, has spread to other parts of the body, or cannot be surgically removed, but whether Cobitinib has an anti-ischemia / reperfusion injury effect has not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of cobimetinib in preparation of medicine for treating ischemia/reperfusion injury and cell protection medicine
  • Application of cobimetinib in preparation of medicine for treating ischemia/reperfusion injury and cell protection medicine
  • Application of cobimetinib in preparation of medicine for treating ischemia/reperfusion injury and cell protection medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Animal experiment: the protective effect of cobimetinib on rat model of myocardial ischemia / reperfusion injury.

[0053] Experimental animals:

[0054] A number of healthy male SD rats weighing 250-300 g. The experimental animals were fed for one week in an environment with a temperature of 25° C., a relative humidity of 60%, free access to drinking water, and regular and quantitative amounts, and then administered according to the requirements of each group in the experiment.

[0055] Rat myocardial ischemia / reperfusion model establishment method: SPF grade Sprague-Dawley rats were anesthetized by intraperitoneal injection of 3% pentobarbital sodium (0.1mL / kg), fixed on the mouse board, and the neck and left chest hair. Connect the rat limbs to the electrocardiogram machine, and observe the changes of the rat electrocardiogram during the operation. Bluntly dissect the neck muscles to expose the trachea, cut a "T"-shaped incision on the trachea, insert the other end ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of cobimetinib in preparation of a medicine for treating ischemia / reperfusion injury and a cell protection medicine. The cobimetinib is used for preparing the medicine for treating ischemia / reperfusion injury, especially the medicine for treating myocardial cell and nerve cell injury, and the medicine has a good protection effect on heart and cerebral ischemia / reperfusion injury (myocardial infarction and cerebral arterial thrombosis), and can obviously relieve the heart and cerebral ischemia / reperfusion injury.

Description

technical field [0001] The invention relates to the application of cobitinib in the preparation of medicines for treating or preventing ischemia / reperfusion injury, which belongs to the field of biomedicine. The present invention provides new uses and administration methods of cobitinib, including the protective effect on heart and cerebral ischemia / reperfusion (especially myocardial infarction and ischemic stroke), and reducing ischemia / reperfusion injury; And cytoprotective drugs are used to protect organs, tissues or cells against cell damage and dysfunction, which expands the scope of indications of Cobitinib; in addition, the present invention also covers Cobitinib in the preparation of myocardial Application of cell damage protection drugs. Background technique [0002] Myocardial infarction is mainly caused by cardiac ischemia. Without timely reperfusion or the absence of collateral circulation, cardiomyocytes are irreversibly damaged and replaced by fibrous scar ti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4523A61P9/10A61P25/00A61P1/16A61P13/12A61P9/00A61P27/02
CPCA61K31/4523A61P9/10A61P25/00A61P1/16A61P13/12A61P9/00A61P27/02
Inventor 彭军罗秀菊彭靖杰杨晓妍张议月彭雅威蒋雅倩段丹清
Owner CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com