Method for plaque detection

A technology of bacterial plaque and dental plaque, which is applied in the fields of pharmaceutical formulation, diagnostic recording/measurement, analysis using fluorescence emission, etc., can solve problems such as difficulty in developing new antibiotics, and achieve the effect of short lifespan

Pending Publication Date: 2022-02-01
科伊特健康有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Antibiotics have helped humans deal with bacterial infections so far, however pathogens have become resistant to most antibiotics, and the difficulty in developing new antibiotics has the potential to return humanity to a pre-antibiotic era

Method used

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  • Method for plaque detection
  • Method for plaque detection
  • Method for plaque detection

Examples

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Embodiment approach

[0102] One embodiment includes

[0103] - subjecting the target tooth region to light having a peak wavelength of about 405 nm or 810 nm or both (optionally sequentially);

[0104] - measuring the first autofluorescence produced by the target tooth region in response to such light, optionally using filtering to distinguish predetermined autofluorescence; then

[0105] - subjecting the target tooth region to light having a peak wavelength of about 405 nm or 810 nm or both in the presence of a plaque-specific photosensitizer (optionally sequentially);

[0106] - measuring the secondary autofluorescence produced by the target tooth region in response to such light, optionally using filtering to distinguish predetermined autofluorescence; and

[0107] - determining the ratio of the first autofluorescence and the second autofluorescence.

[0108] Typically, the rate of adsorption and optionally photobleaching of plaque-specific photosensitizers is determined.

[0109] In one emb...

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Abstract

Method of detecting dental plaque, comprising the steps of subjecting a dental area of interest to high and low energy photons in the presence of a photosensitizer. The invention can be used antimicrobial and antiviral and antifungal detection and therapy. Thus, generally, viral or fungal infections in biofilm, plaque and on teeth surfaces can be detected and optionally treated. The method can also be used for detecting, determining or analysing the quantity or quality or both of the dental pellicle.

Description

technical field [0001] The present invention relates to plaque detection. In particular, the method of the present invention relates to a method for detecting dental plaque comprising the step of subjecting the target tooth area to photons in the presence of a chemical agent, preferably contacting the plaque. Background technique [0002] In biofilms, microorganisms are less sensitive to antimicrobial agents than planktonic bacteria. Mechanisms behind biofilm tolerance and resistance include slow penetration of antimicrobial agents through the biofilm matrix, changes in the microenvironment within the biofilm, differential stress responses of bacterial cells, and the formation of so-called persistent cell subpopulations. In biofilms, potential resistance can be easily transferred between different species through horizontal gene transfer. It is estimated that nearly 80% of microbial infections are caused by biofilms. This is also associated with drug resistance, where sus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B5/107A61B5/145
CPCA61B5/0088A61B5/0075A61B5/0077A61B5/4547A61B5/7225A61B5/1072A61B5/14539A61B5/0071A61B2562/0233A61B2576/02A61K49/0034
Inventor 撒卡里·尼金玛汤米·帕提拉朱哈·兰塔拉
Owner 科伊特健康有限公司
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