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Starch-stop nerve-soothing decoction-autism core action gene target spot and screening method thereof

A screening method and technology for autism, applied in the fields of genomics, biochemical equipment and methods, instruments, etc., can solve the problems of unclear active ingredients and pharmacological mechanism of Qiqi Anshen Decoction

Pending Publication Date: 2022-05-06
AIR FORCE MEDICAL UNIV
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Problems solved by technology

However, the specific effective active ingredients and pharmacological mechanism of Kaishu Anshen Decoction are still unclear.

Method used

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  • Starch-stop nerve-soothing decoction-autism core action gene target spot and screening method thereof
  • Starch-stop nerve-soothing decoction-autism core action gene target spot and screening method thereof
  • Starch-stop nerve-soothing decoction-autism core action gene target spot and screening method thereof

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Experimental program
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Embodiment Construction

[0040] The present invention will be further described below by specific examples.

[0041] Kaishu Anshen Decoction-Autism core gene targets, including the following genes:

[0042] VEGFA, IL6, TNF, INS, PTGS2, CXCL8, AKT1, MMP9, TP53, and EGF.

[0043] Application of the Kaishu Anshen Decoction-autism core function gene target in preparation or screening for treatment of autism.

[0044] The following active ingredients are screened as the preferred objects: quercetin, kaempferol, luteolin, 4'-methyl Hengzhou Wuaconitine, S-(2-carboxyethyl)-L-cysteine ​​and oil acid. .

[0045] A screening method for Kaishu Anshen Decoction-autism core action gene target, comprising the following operations:

[0046] 1) Screen the active ingredients of the whole components of Kaishu Anshen Decoction;

[0047] 2) Screen the targets of the active ingredients of Kaiguan Anshen Decoction, and normalize and standardize the naming of the targets to obtain the potential targets of the active in...

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Abstract

The invention discloses a start-stop nerve-soothing decoction-autism core action gene target spot and a screening method thereof.The screening method includes the steps that intersection target spots of active ingredients and diseases are obtained through database analysis of TCMSP, uniprot and the like, then a protein-protein interaction (PPI) network is constructed, and a result is visually analyzed through Cytoscape software to obtain important modules and core target spots in the PPI network; and carrying out gene GO and KEGG pathway enrichment analysis on the target spot by adopting Metascap, so as to obtain a visual graph of component-target spot-gene function-pathway-disease. The method solves the problems that the number of interactions between multiple active components and multi-target proteins is too large and screening is difficult, and has important application significance for guiding research and development of traditional Chinese medicine compounds.

Description

technical field [0001] The invention relates to the pharmacological research of traditional Chinese medicine compound, in particular to Kaishu Anshen Decoction-autism core action gene target and screening method thereof. Background technique [0002] Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that usually occurs before the age of 3, and the individual phenotypes vary greatly from mild to severe. In 2020, a research report released by the US Centers for Disease Control and Prevention (CDC) showed that the prevalence rate of children with autism has reached 1:54, and it is showing an increasing trend year by year. However, there is still a lack of clear diagnosis, prevention and treatment programs for autism clinically. Therefore, exploring the pathogenesis of autism, seeking practical and effective treatment strategies, and developing novel and effective therapeutic drugs have important research value and clinical significance for the treatment o...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883G16B20/30G16B50/00
CPCC12Q1/6883G16B20/30G16B50/00C12Q2600/136
Inventor 杨奇张梦佳刘庆庆于娇妍
Owner AIR FORCE MEDICAL UNIV
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