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Application of rice bran active peptide in prevention or treatment of lipotoxicity related diseases

A technology of active peptides and lipotoxicity, applied in the field of proteins, to achieve good intervention and therapeutic effects, and the effect of less drug resistance

Pending Publication Date: 2022-05-31
长沙飞创生物技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no relevant literature research on rice bran active peptides in improving cell lipotoxicity in my count

Method used

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  • Application of rice bran active peptide in prevention or treatment of lipotoxicity related diseases
  • Application of rice bran active peptide in prevention or treatment of lipotoxicity related diseases
  • Application of rice bran active peptide in prevention or treatment of lipotoxicity related diseases

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Experimental program
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Embodiment 1

Embodiment 2

[0059] The program cooling box is taken out from the -80°C ultra-low humidity refrigerator, and the nematode cryopreservation tube is taken out after the natural thawing at room temperature. complete solution

[0060] After the recovery is completed, subculture is carried out in diced pieces. Prepare a petri dish containing a large number of C. elegans (called NGM A

Embodiment 3

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Abstract

The invention discloses an application of a rice bran active peptide in preparation of a preparation or food for preventing or treating lipid toxicity related diseases. The sequence of the rice bran active peptide is Lys-His-Asn-Arg-Gly-Asp-Glu-Phe or Lys-His-Asn-Arg-Gly-Asp-Glu. The invention further discloses a preparation method of the rice bran active peptide. Caenorhabditis elegans and C57BL/6J mice are used as model organisms, HepG2 cells are used as research objects, the effects of the rice bran active peptide on regulating lipid transport and improving dietary lipid toxicity are tested, and the result shows that the rice bran active peptide has the effects of reducing lipid toxicity and improving lipid metabolism on both the caenorhabditis elegans and the HepG2 cells. A new pharmacological mechanism of the rice bran active peptide is explained, and a new thought and means are provided for application of the rice bran active peptide in preparation of preparations or food for preventing or treating lipotoxicity related diseases.

Description

Application of rice bran active peptide in prevention or treatment of lipotoxicity related diseases technical field The present invention relates to protein field, particularly the application of rice bran active peptide in preventing or treating lipotoxicity related diseases. use. Background technique With the refinement requirements of people for food, the development and utilization of rice by-products has become a hot research topic. point. Rice bran is the main by-product produced in the process of processing brown rice into white rice, and its rice bran protein plays an important role in its nutritional and Sensitivity has a good advantage. Therefore, the rice bran bioactivity prepared by hydrolysis of rice bran protein has multiple biological activities. Sexual peptides have also gradually received attention. Rice bran active peptides have achieved good results in scavenging reactive oxygen species, anti-oxidation and anti-aging in the body. Effect. Cae...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61P3/04A61P1/16A61P3/10A61P9/10A61P13/12A23L33/18C12P21/06C07K7/06C07K1/18C07K1/16
CPCA61K38/08A61P3/04A61P1/16A61P3/10A61P9/10A61P13/12A23L33/18C12P21/06C07K7/06A23V2002/00A23V2250/55A23V2200/30
Inventor 梁盈陈雅娟王建强母健菲何彰华刘兴
Owner 长沙飞创生物技术有限责任公司
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