Method and apparatus for monitoring coating on particle during manufacturing of pharmaceutical product

A technology of granules and equipment, which is applied in the field of monitoring the formation of coatings on granules, and can solve impossible and difficult problems

Inactive Publication Date: 2003-02-05
ASTRAZENECA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It is therefore difficult, or even impossible, to draw any conclusions from tests performed with known equipment for real particles

Method used

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  • Method and apparatus for monitoring coating on particle during manufacturing of pharmaceutical product
  • Method and apparatus for monitoring coating on particle during manufacturing of pharmaceutical product

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Experimental program
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Embodiment Construction

[0025] Description of the preferred embodiment

[0026] The monitoring equipment disclosed on the accompanying drawings includes a coating chamber 1 , a gas supply equipment 2 , a coating liquid distributor 3 , a spectroscopic testing equipment 4 and a main control equipment 5 . In the coating chamber 1, the coating process of the individual particles P can be monitored continuously and non-invasively under well-controlled conditions.

[0027] A vertical pipe 6 protrudes from the bottom 7 of the chamber 1 along the mid-perpendicular of the chamber 1 . The gas supply 2 is regulated to feed the chamber 1 in a controlled amount. The device 2 communicates with the tube 6 and the peripheral portion 8 of the chamber 1 . The gas flow through the tube 6 is used to levitate or fluidize the particles at a given location in the chamber 1 . The protective gas flow to the peripheral portion 8 serves to minimize any gradients between the measuring device 4 and the particles P, as these g...

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Abstract

In a method of monitoring the formation of a coating on a single particle (P), an apparatus is used which comprises means (2, 5, 6, 9) for arranging said particle (P) at a given spatial location, and a fluid supply unit (3) adapted to apply a coating fluid to the particle (P) such that the coating is formed. Further, the apparatus has a measurement unit (4) which is adapted to perform a spectrometric measurement on the coating during formation thereof, and to derive a measurement value of at least one principal parameter related to the coating. Thus, such principal parameters, for example thickness, thickness growth rate and physical and / or chemical properties related to the quality of the coating, as well as heat, mass and momentum transfer, can be continuously and non-invasively monitored during the coating process on the single particle (P). The results of such measurements can be used to understand the coating process on the single particle (P), and ultimately to control, up-scale and develop industrial full-scale coating plants.

Description

technical field [0001] The present invention relates to methods and apparatus for monitoring the formation of coatings on particles. The present invention mainly focuses on controlling the process of forming coatings for pharmaceutical products such as pills, tablets, capsules and the like. technical background [0002] Typically, the coating of a drug product consists of one or more films and each film contains one or more layers. In the following, "coating" is understood as a general expression covering all cases from a single layer to a combination of several different films. Each film is the result of a film coating step, usually carried out in a coating vessel in which, for example, the layers of the film are formed. The coating process takes place either in a fluidized bed, where the granules, the so-called cores, are sprayed with a special coating liquid, or by transporting these granules through a spray dust of said liquid. Several other common coating methods are...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): G01N21/64B01J2/00B01J2/16G01N21/27G01N21/33G01N21/35G01N21/65G01N21/84G01N21/85
CPCG01N2021/8427G01N21/3563B01J2/16B01J2/006G01N21/359
InventorS·福勒斯塔B·I·尼克拉松A·拉斯穆松D·斯特伦
OwnerASTRAZENECA AB