Polypeptide medicine for inhibiting SARS coronavirus, and derivatives and use thereof

A coronavirus and derivative technology, applied in the direction of viral peptides, biochemical equipment and methods, positive-sense single-stranded RNA viruses, etc.
CN1488641AInactive Publication Date: 2004-04-14INST OF MICROBIOLOGY - CHINESE ACAD OF SCI +1
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
Publication Date
2004-04-14
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention provides a method for blocking SARS coronavirus to infect cell with polypeptide or its derivative. The cistine series of polypeptide comes from two heptad repeat districts HR1 and HR2 of SARS coronavirus spike(S) protein. The invention also provides a method for producing the functional similarity with HR1 and HR2. the invention provides a method for producing HR polypeptide and its derivant with coalescence expression method. All the peptides have rejection capability to SARS.
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Description

Field of invention:

[0001] The invention belongs to the field of molecular biology of viruses. Specifically, it involves the use of the heptad repeat (HR) HR1 and HR2 polypeptides of the SARS coronavirus spike (S) protein and their derivatives to prevent and treat SARS coronavirus infection. Background technique:

[0002] Recently, a contagious severe acute respiratory syndrome (Severe Acute Respiratory Syndrome, SARS) or "atypical pneumonia" broke out all over the world, and its pathogen has been preliminarily identified as a novel coronavirus (Coronavirus). Coronavirus is an enveloped RNA virus. Similar to other enveloped viruses, it needs to release genetic material into the cell through the fusion of the virus envelope and the cell membrane to complete the infection of the cell. Studies on the fusion mechanism of most enveloped viruses have found that they use envelope fusion glycoproteins to mediate the fusion of the viral envelope and the host cell membrane through co...

Claims

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