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Application of human interferon alpha 2a in preparation of medicine for preventing and treating SARS

A technology for atypical pneumonia and interferon α, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., and can solve the problems of unmanned interferon α 2a

Inactive Publication Date: 2005-03-09
MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, no one has reported that interferon α2a is used to prevent and treat SARS.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] Anti-SARS Virus Test of Human Interferon α2a

[0014] 1. Test materials:

[0015] 1. Cells: African green monkey kidney cells (Vero E6), provided by the Molecular Biology Laboratory of the Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences.

[0016] 2. Virus: SARS virus, BJ-01 strain, provided by the Virus Room of the Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, the virus strain has been preserved in the General Microbiology Center of China Microbiological Culture Collection Management Committee, and the preservation number is SARS virus BJ01 CGMCC NO .0936.

[0017] 3. Culture medium: DMEM medium plus 10% calf serum.

[0018] 4. Drugs and sources: human interferon α2a, produced by Shenyang Sansheng Pharmaceutical Co., Ltd., batch number GR020901, 9.58×10 7 IU / ml;

[0019] 2. The basic conditions of the experiment: Viruses were tested in a biosafety level 3 laboratory.

[0020] 3....

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PUM

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Abstract

An application of human interferon alpha-2a, which has high antivirus power, in preparing the medicines for preventing and treating SARS is disclosed.

Description

technical field [0001] The invention relates to a new medical application of human interferon alpha 2a, in particular to the application of interferon alpha 2a in the preparation of drugs for the prevention and treatment of atypical pneumonia. Background technique [0002] Interferon (IFN) is a natural protein that has a therapeutic effect on viral infections and certain tumor diseases. In the treatment of viral infections, interferon is currently recognized as the drug of choice. According to different sources, interferon can be divided into IFNα, IFNβ, IFNγ and IFNω and other types, among which α-type interferon has multiple subtypes such as α1b, α2a, α2b and so on. [0003] Human α2a-type interferon (IFN-α2a) is a single-chain polypeptide composed of 165 amino acids with a molecular weight of 19.219kD. It is an antiviral and antitumor polypeptide drug that has been mass-produced and widely used in the world. It has anti-proliferative effects on different human tumors, ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/21A61P11/00A61P31/14
Inventor 王京燕赵艳红纪晓光李晓萸张敏赵京花张永祥
Owner MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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