Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Buccal interferon tablet and preparation method thereof

A technology of interferon and interferon α, applied in the direction of medical preparations containing active ingredients, pill delivery, antiviral agents, etc., can solve the problem of unfinished sublingual lozenges, achieve safe and reliable drug administration, and smooth taste , the effect of being willing to accept

Active Publication Date: 2014-08-13
FUJIAN COSUNTER PHARMA CO LTD
View PDF12 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In conclusion, although there are above-mentioned research works on HuIFNα-1b, HuIFNα-2b, and HuIFNβ buccal tablets, the preparation of HuIFNα-2a and HuIFNα-2b into sublingual tablets that maintain interferon activity, facilitate interferon absorption, and have medicinal effects The lozenge study was not done

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Buccal interferon tablet and preparation method thereof
  • Buccal interferon tablet and preparation method thereof
  • Buccal interferon tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 Preparation of recombinant human interferon alpha-2a buccal tablet

[0059] Material composition: recombinant human interferon alpha-2a (outsourced, the same below) 300 IU

[0060] A total of 100 grams of accessories, including:

[0061]

[0062] Preparation Process:

[0063] The entire preparation process is carried out in a sterile room.

[0064] Take each auxiliary material according to the above prescription, first mix each auxiliary material evenly, pass through an 80-mesh sieve, and sterilize by ultraviolet irradiation for later use.

[0065] Weigh recombinant human interferon alpha 2a, mix well with 50 g of the adjuvant mixture, and then add 50 g of the adjuvant mixture and mix evenly for use.

[0066] The mixed raw and auxiliary material mixture is directly compressed with a 6mm concave die, and the tablet weight is adjusted to be about 100mg, the hardness is 3-4kg, and 1000 tablets are made.

Embodiment 2

[0067] Example 2 Preparation of recombinant human interferon alpha-2b buccal tablet

[0068] Material composition: recombinant human interferon alpha-2b (purchased) 300 IU

[0069] A total of 100 grams of accessories, including:

[0070]

[0071] The preparation process is the same as in Example 1.

Embodiment 3

[0072] Example 3 Preparation of recombinant human interferon alpha-2a buccal tablet

[0073] Material composition: Recombinant human interferon alpha-2a 500 IU

[0074] A total of 100 grams of accessories, including:

[0075]

[0076] The preparation process is the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
hardnessaaaaaaaaaa
Login to View More

Abstract

The invention relates to a peptide-contained medical product and a preparation method thereof, particularly to a recombinant human interferon alpha-2a and alpha-2b sublingual tablet and a preparation method thereof. The sublingual tablet provided by the invention has the characteristics of good stability, easy absorption for a human body, safe and reliable administration, simple and convenient preparation method and the like.

Description

technical field [0001] The present invention relates to a pharmaceutical preparation containing peptides and a preparation method thereof, in particular to human recombinant interferon α-2a, α-2b sublingual tablets and a preparation method thereof. Background technique [0002] Interferon research has become an important field in virology, cytology, immunology, clinical medicine, molecular biology and oncology. It has a wide range of antiviral activities. In 1957, Isaacs and Lindenmann discovered this substance when they were studying the interference phenomenon of influenza virus: when inactivated influenza virus acts on cells, the cells will produce a soluble substance, which makes the living virus cells soluble. Reproduction is disturbed, so it is called interferon (Interferon, abbreviated IFN). Interferon has been proved to be a class of active proteins with broad-spectrum antiviral, antiproliferative and immunomodulatory functions. It is clinically used to treat viral...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K38/21A61K47/38A61K47/34A61K47/10A61P31/12A61P1/16A61P1/02A61P21/00A61P37/06
Inventor 姚建堤陈首鹤陈仕魁杨喜鸿苏葳
Owner FUJIAN COSUNTER PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com