Sulfony lated acetylglucosamine medicinal composition and its use

A technology of sulfonylated acetamido and polysulfonylated acetamido, applied in the field of preparation of drugs for the treatment of degenerative osteoarthritis, to delay the progress of degenerative changes, with good toxicological safety and strong hygroscopicity Effect

Inactive Publication Date: 2005-05-04
ZHUHAI CLEANSTAR CLEANING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report about the pharmaceutical composition of sulfonylated ac

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Embodiment 1 (oral capsule and tablet)

[0067] Under dry environmental conditions, weigh each component according to the proportion (by weight), i.e., 70% sulfonylated acetylglucosamine oligosaccharide, 20% acetylglucosamine oligopolyglucosamine, and 10% hydroxylysine, and mix well According to conventional methods, granulate, encapsulate moisture-proof, pack in capsules, each capsule contains 0.5g of medicine, or add appropriate amount of compressive agent to press into tablets, apply moisture-proof film, each tablet contains 0.5g of medicine, and the usage is oral administration of 0.5g, 2 -4 times / day.

Embodiment 2

[0068] Embodiment 2 (oral capsule and tablet)

[0069] The preparation method is the same as that of Example 1, only the distribution ratio of each component is changed, that is, 90% of sulfonylated acetylglucosamine, 1% of glucosamine and 9% of hydroxylysine.

Embodiment 3

[0070] Embodiment 3 (oral capsule and tablet)

[0071] The preparation method is the same as in Example 1, only the distribution ratio of each component is changed, that is, 1% of oligosulfonylated acetylglucosamine, 90% of oligoacetylglucosamine, and 9% of hydroxylysine.

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PUM

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Abstract

The present invention relates to a sulfonyl acetylglucosamine medicine composition and its application in preparation of medicine for curing retrograde osteoarthropathy. Said medicine composition is formed from 1-90% of sulfonyl acetylglucosamine, 90-1% of acetylglucosamine and 1-10% of hydroxylysine. Said invented oral preparation or fluid infusion preparation has the notable therapeutical effect for curing the diseases of senile osteoarthropathy, scapulohumeral periarthritis, articular cartilage synovial injury by collision, cartilage synovial injury and chondronecrosis of head of femur, cartilaginous synvium restoration of rheumatoid arthritis in stable stage and fatigue osteoarthritis, etc.

Description

technical field [0001] The invention relates to a sulfonylated acetylglucosamine pharmaceutical composition and application thereof. More specifically, the present invention relates to a pharmaceutical composition of sulfonylated acetylglucosamine and its application in the preparation of medicines for treating degenerative osteoarthritis. Background technique [0002] Everyone knows the phenomenon of "legs get old first when people get old". Physiologically, cartilage degenerative changes begin to occur after the age of 30, and most people begin to have symptoms of joint discomfort after the age of 40, especially when the joints are subjected to a strong impact when long jumping or jumping from a high place. The old man has a narrow stride, and the clinical manifestations are joint pain and stumbling, narrowing of the bone joint space, and obvious joint pain when going up and down stairs. In the past, it was believed that this kind of systemic bone and joint degeneration ...

Claims

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Application Information

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IPC IPC(8): A61K31/7008A61P19/08
Inventor 王浦林
Owner ZHUHAI CLEANSTAR CLEANING TECH
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