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Wikipedia for application of altitude medicine

A technology of sildenafil and other aspects, applied in sildenafil, a new kind of medicine in the field of plateau medicine, can solve the problems of no patent application and acceptance reports, etc., to improve the body's resistance to acute and chronic hypoxia and The ability of hypoxia, the effect of good economic and social benefits

Inactive Publication Date: 2006-03-29
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no domestic research report on the ability of oral sildenafil to increase the body's ability to cope with altitude sickness, and there are no reports of foreign patent applications and acceptance in this regard

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment one: Sildenafil improves human body's ability to resist acute hypoxia

[0018] 1. Materials and Methods

[0019] Viagra tablets produced by Pfizer Pharmaceuticals of the United States contain 50 mg of sildenafil per tablet. 14 healthy young volunteers, male, in good health, were informed in advance of the administration method, adverse reactions and toxic side effects of sildenafil, and were aware of the hazards of hypoxia and hypoxia, and participated in the whole experiment completely voluntarily.

[0020] The test was carried out at sea level, using a low-pressure oxygen chamber with the partial pressure of oxygen set at 10% (equivalent to an altitude of 6500m). Using the experimental principle of self-control, measure relevant parameters and indicators before and after entering the hypobaric oxygen chamber, take sildenafil after a long enough interval, and enter the hypobaric oxygen chamber again for the same time to ensure that there is no inte...

Embodiment 2

[0026] Embodiment 2: Sildenafil improves human body's ability to resist acute hypoxia

[0027] 1. Materials and Methods

[0028] Viagra tablets produced by Pfizer Pharmaceuticals of the United States contain 50 mg of sildenafil per tablet. 14 healthy mountaineering athletes, male, in good health, were informed in advance of the administration method, adverse reactions and toxic side effects of sildenafil, and were also aware of the hazards of hypoxia and hypoxia, and participated in the entire experiment on a completely voluntary basis. Tablets with the same dosage form and similar or similar appearance are used as placebos.

[0029] The test was carried out at the Everest Mountaineering Camp for 8 days. The first day was at an altitude of 2880m, the second day at an altitude of 3440m, the fourth day after one day at an altitude of 3867m, the fifth day at an altitude of 4240m, and the sixth day at an altitude of 4930m. , on the 7th day to an altitude of 5...

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PUM

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Abstract

An application of sildenafil in improving the resistance of human body and other animals to altitude anoxia and low-oxygen environment by orally taking it is disclosed.

Description

technical field [0001] The invention relates to a new application of sildenafil in the field of plateau medicine. Sildenafil (English name Sildenafil, trade name Viagra, Viagra, viagra) can significantly increase the body's ability to resist plateau hypoxia and hypoxia under the condition of oral administration. Background technique [0002] The biggest difference in plateau areas is that the partial pressure of oxygen is lower than sea level, and the most direct reaction of the body after entering the plateau area is the lack of oxygen. According to the level of oxygen partial pressure, it is generally called hypoxia, and severe hypoxia is called hypoxia. Hypoxic or hypoxic conditions are also sometimes encountered by people working at sea level, such as diving and dry ice operations. The body's response to hypoxia and hypoxia has always been an important content of pathophysiology, applied physiology, altitude medicine and sports medicine research, and is also an importa...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61P43/00A23L1/30
Inventor 赵永岐范明刘淑红吴燕赵彤丁爱石王鲁明吴海涛
Owner INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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