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Medicament for treatment of nocturia

a technology for nocturia and nocturia, which is applied in the direction of biocide, drug composition, urinary disorder, etc., can solve the problems of insufficient sleep, and lower urinary tract symptoms (luts) becoming major health problems for elderly peopl

Inactive Publication Date: 2004-03-18
SANKYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lower urinary tract symptoms (LUTS) are becoming a major health problem for elderly people worldwide.
Nocturia, a cause of insufficient sleep and thus impaired quality of life, is one of the main problems in LUTS along with urinary incontinence and difficulty in urination.
However, in the inventor's experience, about one-half of such patients do not respond well to these medications.

Method used

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Embodiment Construction

[0015] The present invention will be explained more specifically by way of examples. However, the scope of the present invention is not limited to these examples.

[0016] Patients and Methods

[0017] One hundred forty one patients (136 men) aged 49 to 89 (mean 70.5) years with LUTS and =2 voids per night were enrolled in the study. Their main diseases were BPH (n=93), prostate cancer (n=24) and neurogenic bladder (NB) (n=13); 11 had other diseases. The majority of patients had failed to respond to anticholinergic drugs, hypnotics and / or other medications for nocturia prescribed in addition to their treatments for their main diseases. Patients who had asthma, gastrointestinal disorders, renal dysfunction and allergies to loxoprofen were excluded.

[0018] Patients took a single 60 mg loxoprofen tablet prior to sleeping at night for 4 to 14 days initially concurrently with their treatments for their main diseases. Numbers of voids / night as reported by each patient were evaluated and treatmen...

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Abstract

A method for preventive and / or therapeutic treatment of nocturia, which comprises the step of administering to a mammal including a human in need of such treatment a preventively and / or therapeutically effective amount of a nonsteroidal anti-inflammatory drug such as loxoprofen.

Description

FIELD OF THE INTENTION[0001] The present invention relates to a preventive and / or therapeutic treatment of nocturia.RELATED ART[0002] Lower urinary tract symptoms (LUTS) are becoming a major health problem for elderly people worldwide. Nocturia, a cause of insufficient sleep and thus impaired quality of life, is one of the main problems in LUTS along with urinary incontinence and difficulty in urination. The aetiology of nocturia is various and complex and obscure in many patients, although LUTS, insomnia, nocturnal polyuria due to cardiovascular or renal hypofunction and disorders of the central nervous system (CNS) may be among the causes (Resnick N. M., et al., Campbell's Urology, 7th edn, Vol.2. Chapt 31. Philadelphia: Saunders, 1998: 1044-68).[0003] The aetiology of nocturia is still obscure in many patients, even in those with BPH. In patients whose causes of nocturia are affirmable, such as those with LUTS, sleep disorder and nocturnal polyuria, nocturia may be improved by ef...

Claims

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Application Information

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IPC IPC(8): A61K31/192
CPCA61K31/192A61K31/19A61P13/00A61P29/00
Inventor ARAKI, TOHRU
Owner SANKYO CO LTD
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