Protein Kinase Targeted Therapeutics

a protein kinase and targeted technology, applied in the field of protein kinase targeted therapeutics, can solve the problems of previous inhibitors having problems directly or indirectly related to the molecular properties of compounds, and the target (e.g., inhibiting) intracellular protein kinases

Inactive Publication Date: 2008-02-28
NORTHWESTERN UNIV
View PDF3 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006] The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1δ, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MA

Problems solved by technology

Previous efforts to target (e.g., inhibit) intracellular protein kinases related to MAPK (e.g., p38 MAPK, JNK, ERK) and CK (e.g., CK1δ) have b

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Protein Kinase Targeted Therapeutics
  • Protein Kinase Targeted Therapeutics
  • Protein Kinase Targeted Therapeutics

Examples

Experimental program
Comparison scheme
Effect test

example i

Compound Synthesis Schemes

[0070]FIG. 1 shows different exemplary routes of synthesis for the compounds, small molecules, and analogs thereof of the present invention.

[0071] 1-Phenyl-2-(pyridin-4-yl)ethanone: (2) To a stirred solution of lithium diisopropylamide (1.5 eq) in THF at −78° C. a solution of 4-picoline (1 eq) in THF is added slowly. After 15 min, a solution of N-methoxy-N-methylbenzamide (1.2 eq) in THF is added. The reaction mixture is allowed to warm to ambient temperature. The formation of product is monitored by HPLC. The reaction mixture is poured into a saturated aqueous sodium bicarbonate solution, then extracted with ethylacetate. The organic phase is washed with brine, dried over anhydrous magnesium sulphate and evaporated under reduced pressure to give the crude product. The crude product is then purified by flash column chromatography (25-100% EtOAc-hexane) to give the product ketone 2. Purity >90%, ESI m / z 198.18 (MH+).

[0072] Ethyl 4-oxo-4-phenyl-3-(pyridin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Compositionaaaaaaaaaa
Login to view more

Abstract

The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1δ, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or CK pathways (e.g., CK1δ, and upstream and downstream protein kinases).

Description

[0001] The present application claims priority to U.S. Provisional Application No. 60 / 834,962, filed Aug. 2, 2006, which is herein incorporated by reference in its entirety.[0002] This application was funded in part through a National Institute of Health Grant No. NS 047586. The government may have certain rights in this invention.FIELD OF THE INVENTION [0003] The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and / or casein kinase (CK) pathways (e.g., CK1δ, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and / or CK pathways (e.g., CK1δ, and upstream a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/50A61P43/00
CPCA61K31/50A61K45/06A61K2300/00A61P29/00A61P43/00
Inventor WATTERSON, D. MARTINVAN ELDIK, LINDA J.
Owner NORTHWESTERN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap