7 results about "Casein kinases" patented technology

The present application relates to compounds of Formula (I) or an enantiomer thereof, or a pharmaceutically acceptable salt, solvate and / or prodrug thereof. The application relates to compositions comprising these compounds, to processes for their preparation, and their use in therapy such as in the treatment or prevention of fungal-related diseases, disorders or conditions.

The invention belongs to the technical field of plant genetic engineering, and particularly relates to application of corn casein kinase ZmCK2 beta or a coding gene thereof in regulation and control of corn resistance to corn yellow mosaic virus. The host protein ZmCK2 beta interacting with the CP is obtained through screening, it is found that ZmCK2 beta and ZmCK2 alpha can interact inside and outside a plant body, and CP and ZmCK2 alpha only interact in the plant body; the ZmCK2 beta and the ZmCK2 alpha-ZmCK2 beta complex in the plants are respectively silenced, and after the MaYMV is inoculated, the virus accumulation amount on the silenced plants is reduced, which indicates that the silenced ZmCK2 beta and the silenced ZmCK2 alpha-ZmCK2 beta complex can inhibit infection; a ZmCK2 beta-knockout transgenic corn strain is constructed, and it is found that the virus accumulation amount on the plant is also reduced after ZmCK2 beta is knocked out. The invention provides a scientific basis for deeply analyzing the MaYMV pathogenic mechanism, and lays a theoretical foundation for formulating a virus prevention and control strategy.

The invention relates to the technical field of plant genetic engineering, in particular to a GhCKA1 protein and application thereof in regulating and controlling the disease resistance of cotton verticillium wilt. The invention provides a gene casein kinase GhCKA1 related to disease resistance of cotton verticillium wilt. According to the invention, the effect of the GhCKA1 gene in regulating and controlling the disease resistance of the cotton verticillium wilt is defined for the first time, and a new target gene is provided for preventing and controlling the cotton infected by the verticillium wilt. The GhCKA1 gene disclosed by the invention can be used for preventing and treating cotton verticillium wilt, and particularly can be used for genetic improvement or molecular breeding of cotton verticillium wilt resistance, such as cultivation of new varieties of cotton with verticillium wilt resistance. A new way is provided for cultivation of cotton verticillium wilt resistant plants, and theoretical guidance and genetic resources are provided for improvement of cotton disease resistance through molecular design breeding or genetic engineering.

The invention discloses application of casein kinase in regulation and control of flowering and leaf development of medicago sativa, and belongs to the technical field of biological genetic engineering. The multifunctionality of MsPPK3 as a key regulatory factor in coordination of vegetative growth and reproductive growth balance of medicago sativa is clarified for the first time, and specifically, MsPPK3 positively regulates plant reproductive growth and negatively regulates plant vegetative growth. Wherein the positive regulation and control of the reproductive growth of the plant is embodied in overexpression early flowering and silence late flowering. The negative regulation and control of plant vegetative growth is characterized in that the overexpressed plant is in a fine stem scattered form, and leaves are miniaturized, thinned and / or weakened form; the silent plants present a thick stem cluster type, a large leaf size, a thick leaf and / or a strengthened leaf. The method has great significance in the aspects of cultivation of different new varieties / new strains of alfalfa and the like.

This disclosure provides casein kinase inhibitors or pharmaceutically acceptable salts thereof. Corresponding compositions, treatment methods, and intermediates are also provided.

The present application relates conjugate compounds of Formula (I): A-L1-B(I) wherein: A is a moiety that increases fungal cell uptake and / or fungal cell permeability; B is a CK1 inhibiting moiety; and L1 is a linker; or pharmaceutically acceptable salts, solvates and / or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and / or prodrugs thereof, to processes for their preparation, and their use in therapy such as in the treatment or prevention of fungal-related diseases, disorders or conditions.

This invention discloses rice Hd6 Application of genes in enhancing broad-spectrum disease resistance in rice. The rice mentioned... Hd6 The gene has an open reading frame of 1167 bp, encoding an α subunit of casein kinase CK2 composed of 388 amino acids. This invention relates to the rice... Hd6 The open reading frame of the gene was constructed onto the pCXUN plasmid, transformed into Agrobacterium tumefaciens EHA105, and then obtained from the japonica rice variety Zhonghua 11 under the background of Agrobacterium-mediated transformation of mature rice embryos. Hd6 Overexpression plants. Inoculation experiments with *Bacillus oryzae* and *Bacillus oryzae* were conducted on wild-type and overexpression plants, respectively. The results showed that... Hd6 Overexpression significantly enhanced the resistance of plants to infection by rice blast fungus and bacterial blight fungus, indicating that... Hd6 Positive gene regulation of broad-spectrum disease resistance in rice can be applied to the breeding of disease-resistant rice varieties.