Method for producing a protein of interest at the site of a clot

a clot site and protein technology, applied in the direction of peptide/protein ingredients, immunological disorders, metabolism disorders, etc., can solve the problems of cytokine and interferon production and ultimately cell death, and achieve rapid elimination of lipid nanoparticles, increase hemoglobin, and therapeutic
US20130237592A1Inactive Publication Date: 2013-09-12MODERNA THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MODERNA THERAPEUTICS INC
Publication Date
2013-09-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and / or activity.
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Description

REFERENCE TO SEQUENCE LISTING

[0001] The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing file, entitled M11CON5SQLST.txt, was created on May 17, 2013 and is 25,618 bytes in size. The information in electronic format of the Sequence Listing is incorporated herein by reference in its entirety.CROSS REFERENCE TO RELATED APPLICATIONS

[0002] This application is a continuation of U.S. patent application Ser. No. 13 / 714,458, filed Dec. 14, 2012, entitled Modified Nucleoside, Nucleotide, and Nucleic Acid Compositions which claims priority to U.S. Provisional Patent Application No. 61 / 576,705, filed Dec. 16, 2011, entitled Modified Nucleoside, Nucleotide, and Nucleic Acid Compositions, U.S. Provisional Patent Application No. 61 / 618,957, filed Apr. 2, 2012, entitled Modified Nucleoside, Nucleotide, and Nucleic Acid Compositions, U.S. Provisional Patent Application No. 61 / 648,244, filed May 17, 2012, entitled Modified Nucleoside, Nucleoti...

Claims

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