Monoclonal antibody against podocalyx-like protein precursor subtype 2 functionally expressed on the surface of gastric cancer cells and its preparation method and use

A monoclonal antibody, functional technology, applied in the field of biopharmaceuticals, can solve problems such as limiting the research and application of Brichory ideas
CN105504060BActive Publication Date: 2018-10-26ι™†ζ’…η”Ÿ +3
3 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
ι™†ζ’…η”Ÿ
Publication Date
2018-10-26

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

Provided are a monoclonal antibody of a podocalyxin-like protein precursor subtype 2 (PODXL-v2) functionally expressing an anti-gastric cancer cell surface and a preparation method and use thereof, wherein the amino acid sequence of the light chain variable region of the antibody is SEQ ID NO: 2 or the conservative variation sequence thereof, and the amino acid sequence of the heavy chain variable region is SEQ ID NO: 4 or the conservative variation sequence thereof.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to the field of biopharmaceuticals, in particular to a monoclonal antibody (named MS17-38) against the functional expression of procalyx-like protein subtype 2 (PODXL-v2) on the surface of gastric cancer cells and its preparation method and use. Background technique

[0002] As the inventor Lu Meisheng et al. previously applied for the patent "anti-cell surface ectopically expressed monoclonal antibody MS17-57 and its preparation method and use" (patent application number: 201310090565.9, published and approved), Gastric cancer (GC) is the most common malignant tumor of the digestive system in humans and one of the leading causes of tumor-related death. Countries such as China and Japan have the highest incidence rate of gastric cancer in the world, with nearly 600,000 to 700,000 new cases each year, accounting for the majority of the world's cases. Many patients with gastric cancer are already in the late clinical stage...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More