Implantable CLIPT illumination system

a clipt and illumination system technology, applied in the field of continuous low irradiance photodynamic therapy, can solve the problems of limited adoption of pdt as a form of cancer treatment, lack of penetration of energy, and complexity of therapy administration

Active Publication Date: 2017-05-16
ROGERS SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The IM-LDD achieves high tumor response with minimal side effects by providing precise, repeatable, and prolonged light delivery to deep-seated tumors, reducing morbidity and enabling chronic care with improved mechanical properties and optical efficiency.

Problems solved by technology

Widespread adoption of PDT as a form of cancer treatment has been limited by a number of factors, most notably excessive morbidity, lack of penetration of the energy and the complexity of administering the therapy.
This weaved fiber approach provides imprecise quantities of light at the treatment site because the bending (the mechanism of light leakage) of the fiber is not uniform from bend to bend and the location of bending along similarly aligned fibers can be random from fiber to fiber.
Not only is the light uniform inconsistent, the device is heavy, not flexible, has low optical efficiency, and is not scalable to larger areas.
This was a problem with both the 1st Gen LDD woven architecture and with the new 2nd Gen LDD.

Method used

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Embodiment Construction

[0022]The present invention aims to evolve already established light diffusion developments in CLIPT technology by creating an implantable light delivery device (IM-LDD) that can be inserted for temporary or extended periods into the cavities within the human body and along luminal surfaces, including, but not limited to the esophagus, upper and lower GI tract, genito-urinary tract, bladder, pelvis, peritoneum, pulmonary cavity, hepatobilliary tree, bronchial tree, blood vessels and calvarium / CNS.

[0023]The advancement of an IM-LDD will address the unmet need for developing low-morbidity, high-impact therapies for advanced-stage cancers in or around these luminal surfaces and body cavities. The IM-LDD can be used without drugs as an internal illumination and energy source only. Additionally, the IM-LDD could be used in binary therapies with drugs including photosensitizers for use in PDT and CLIPT, chemotherapeutic agents, nanoparticles including polyethylene glycol-coated gold nanor...

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Abstract

A light-based therapy device is provided that includes a controller mechanism that produces power and control signals to enable operation of one or more medical devices. An implantable light delivery device (IM-LDD) is coupled to the controller mechanism that receives the power and the control signals to enable a light source to emit sufficient illumination. The light source is implanted within body cavities enabling energy at one or more wavelengths to reach and provide therapy treatment to a selected region.

Description

PRIORITY INFORMATION[0001]This application claims priority from provisional application Ser. No. 61 / 723,526 filed Nov. 7, 2012, which is incorporated herein by reference in its entirety.BACKGROUND OF THE INVENTION[0002]The invention is related to the field of Continuous Low Irradiance Photodynamic Therapy (CLIPT), and in particular to an implantable CLIPT illumination system.[0003]Photodynamic Therapy (PDT) is a two-step, drug-device combination therapy that uses specific wavelengths of light to activate photosensitive drugs to kill cancer cells. Widespread adoption of PDT as a form of cancer treatment has been limited by a number of factors, most notably excessive morbidity, lack of penetration of the energy and the complexity of administering the therapy. CLIPT was introduced as a new therapeutic paradigm to reduce these standard PDT limitations and side-effects by delivering light at ultra-low dose-rates (0.1-0.5 mW) over a period of hours to days compared to traditional PDT deli...

Claims

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Application Information

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Patent Type & AuthorityPatents(United States)
IPC IPC(8): A61N5/06
CPCA61N5/0603A61N5/0601A61N5/062A61N2005/0602A61N2005/063A61N2005/0604A61N2005/0609A61N2005/0659
InventorROGERS, GARY S.HILL, SAMUEL L.
OwnerROGERS SCI