Preparation method of concentrated type heat-clearing and detoxicating oral liquid

A technology for clearing away heat and detoxifying and taking oral liquid, which is applied in the directions of medical preparations, antiviral agents, and pharmaceutical formulations containing active ingredients, which can solve the problems of poor production safety, large amount of ethanol, and high energy consumption, and can ensure product quality and safety. The effect of stability, shortening production cycle and improving production efficiency

CN101628077BInactive Publication Date: 2011-05-04HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2011-05-04
Estimated Expiration
Not applicable · inactive patent
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Abstract

The invention relates to a preparation method of concentrated type heat-clearing and detoxicating oral liquid. The preparation contains twelve medicinal materials of gypsum, honeysuckle, figwort, rehmannia root, weeping forsythia, gardenia, herba gueldenstaedtiae, baikal skullcap root, rough gentian, radix isatidis, rhizoma anemarrhenae and ophiopogon root. When being prepared, an ultrasonic extraction method, a chitosan flocculation method for impurity removal and a microwave sterilization technology are adopted, so that the effective components of the medicinal materials are extracted completely, the medicine concentration is increased, and the content of the effective components is enhanced; the production efficiency is enhanced, and the production cost is lowered. As the effective concentration in the unit volume of the medicine in the invention is doubled, the oral dosage of the medicine is correspondingly reduced, taking and carrying can be more convenient, wrapping materials are saved, and the invention is beneficial to environmental protection.
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Description

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method of concentrated heat-clearing and detoxifying oral liquid. Background technique

[0002] Qingrejiedu Oral Liquid is a traditional Chinese medicine oral liquid preparation extracted and refined from gypsum, honeysuckle, scrophulariaceae, rehmannia, forsythia, gardenia, candiding, scutellaria baicalensis, gentian, isatis root, Anemarrhena anemarrhena, and Ophiopogon japonicus. , has the function of clearing heat and detoxifying. It is used for fever, flushed face, irritability and thirst, and sore throat caused by excessive heat and toxin; flu and upper respiratory tract infection see the above syndromes. The clinical application is wide, the curative effect is good, and there is no toxic or side effect, and it is welcomed by the majority of patients.

[0003] The preparation method of Qingrejiedu oral liquid recorded...

Examples

Embodiment 1

[0028] (a) By weight percentage: gypsum 42.83%, Scrophulariaceae 7.90%, Rehmannia glutinosa 6.10%, Forsythia 4.29%, Gardenia 4.29%, Sweet Diding 4.29%, Gentian 4.29%, Banlangen 4.29%, Anemarrhena 3.45% , Ophiopogon japonicus 3.45%, add the water of 10 times of amount of the sum of above-mentioned drug raw material weight, after heating to be boiled, stop heating, add honeysuckle 9.82%, Scutellaria baicalensis 5.00% after temperature is down to below boiling point, ultrasonic extraction (frequency 25KHz, Power 20kW) two times, 20min each time, filter, combine the filtrate, concentrate the filtrate under reduced pressure to a relative density of 1.05-1.10 (measured at 60°C), and obtain the extract concentrate.

[0029] (b) extract the concentrated solution obtained in step a, add chitosan flocculation clarifying agent with a concentration of 0.1% under the condition of 60 ° C, so that the chitosan content in the liquid reaches 0.10%, stir for 20 minutes, place for 24 hours, and t...

Embodiment 2

[0032] (a) By weight percentage: gypsum 44.64%, Scrophulariaceae 7.13%, Rehmannia glutinosa 5.33%, Forsythia 4.46%, Gardenia 4.46%, Sweet Diding 4.46%, Gentian 4.46%, Banlangen 4.46%, Anemarrhena 3.60% , Ophiopogon japonicus 3.60%, add the water of 12 times of amount of the sum of above-mentioned drug raw materials weight, after heating, after boiling, stop heating, add honeysuckle 8.93%, Scutellaria baicalensis 4.47% after temperature is down to below boiling point, ultrasonic extraction (frequency 40KHz, Power 15kW) two times, each time for 30min, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to about 1:1 of the sum of the weight of the medicinal solution and the weight percentage of each raw material to obtain the extraction concentrate.

[0033] (b) Add 0.1% chitosan flocculation clarifier to the extract concentrate at 55°C to make the liquid contain chitosan up to 0.11%, stir for 20 minutes, place for 24 hours, take the supernatant and f...

Embodiment 3

[0036](a) Taken by weight percentage: gypsum 45.10%, Scrophulariaceae 6.00%, Rehmannia glutinosa 6.50%, Forsythia 4.60%, Gardenia 4.60%, Sweet Diding 4.60%, Gentian 4.60%, Banlangen 4.60%, Anemarrhena 3.70% , Ophiopogon japonicus 3.70%, add the water of 14 times of amount of the sum of above-mentioned drug raw materials weight, after heating to be boiled, stop heating, add honeysuckle 8.00%, Scutellaria baicalensis 4.00% after temperature is down to below boiling point, ultrasonic extraction (frequency 75KHz, power 17kW) twice, each time for 40min, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.05-1.10 (measured at 60°C), or concentrate to the sum of the weight of the medicinal solution and the weight percentage of each raw material About 1:1, the extraction concentrate is obtained, and the extraction concentrate is obtained.

[0037] (b) Add 0.1% chitosan flocculation clarifier to the extract concentrate at 70°C to...