Penicillins medicine capsule and preparation method of same

Abstract

The invention provides a penicillin medicine capsule, wherein a capsule shell containing hydroxypropyl starch can maintain the capsule to be stable and prevent the materials in the capsule shell from being wetted and penicillin from being degraded, thereby increasing in-vitro dissolubility and bioavailability of the capsule and further improving quality stability of the capsule.

Description

Technical field

[0001] The invention relates to a penicillin capsule, specifically a capsule with a capsule shell containing hydroxypropyl starch, which belongs to the technical field of medicine. Background technique

[0002] Capsules are widely used in the pharmaceutical industry. As one of the main ingredients, the capsule shell is a kind of shell that protects the medicine. It not only protects the medicine from being destroyed, but also reduces the irritation of the medicine to the respiratory tract and digestive organs. Therefore, a capsule preparation that is safe, effective, quality controllable and has good pharmacoeconomic value has good economic value and pharmaceutical value.

[0003] Traditional gelatin capsules have many safety risks, because traditional gelatin capsules use animal protein colloidal gelatin prepared by hydrolysis of animal skin and bone as the capsule shell material. Due to limited sources, unscrupulous merchants use processed scraps of industrial le...

Examples

Embodiment 1

[0034] Example 1 Preparation of capsule shell containing hydroxypropyl starch

[0035] prescription:

[0036] Raw materials

Dosage

Hydroxypropyl starch

80g

Carrageenan

7g

Chitosan

5g

Sodium Citrate

3.5g

Triethyl Citrate

2.7g

Propylene Glycol

2g

[0037] Preparation:

[0038] (1) Gelatinization: Put purified water into the gelatinization tank, heat it to 80-100℃, then add hydroxypropyl starch, keep stirring for 90-180min; then add the remaining ingredients, stir for 10-15min, add activated carbon and stir for decolorization 15min, filter to the incubator for temporary storage;

[0039] (2) The obtained glue solution is processed into a hydroxypropyl starch hollow capsule shell by a fully automatic hollow capsule manufacturing machine.

Embodiment 2a-2d

[0060] Examples 2a-2d Preparation of amoxicillin capsule contents (0.25g specification, 1000 capsules)

[0061] excipient

[0062] Preparation Process:

Embodiment 2a

[0064] 1. Mix amoxicillin and magnesium stearate evenly and set aside.

Technical field

[0001] The invention relates to a penicillin capsule, specifically a capsule with a capsule shell containing hydroxypropyl starch, which belongs to the technical field of medicine. Background technique

[0002] Capsules are widely used in the pharmaceutical industry. As one of the main ingredients, the capsule shell is a kind of shell that protects the medicine. It not only protects the medicine from being destroyed, but also reduces the irritation of the medicine to the respiratory tract and digestive organs. Therefore, a capsule preparation that is safe, effective, quality controllable and has good pharmacoeconomic value has good economic value and pharmaceutical value.

[0003] Traditional gelatin capsules have many safety risks, because traditional gelatin capsules use animal protein colloidal gelatin prepared by hydrolysis of animal skin and bone as the capsule shell material. Due to limited sources, unscrupulous merchants use processed scraps of industrial le...

Examples

Embodiment 1

[0034] Example 1 Preparation of capsule shell containing hydroxypropyl starch

[0035] prescription:

[0036] Raw materials

Dosage

Hydroxypropyl starch

80g

Carrageenan

7g

Chitosan

5g

Sodium Citrate

3.5g

Triethyl Citrate

2.7g

Propylene Glycol

2g

[0037] Preparation:

[0038] (1) Gelatinization: Put purified water into the gelatinization tank, heat it to 80-100℃, then add hydroxypropyl starch, keep stirring for 90-180min; then add the remaining ingredients, stir for 10-15min, add activated carbon and stir for decolorization 15min, filter to the incubator for temporary storage;

[0039] (2) The obtained glue solution is processed into a hydroxypropyl starch hollow capsule shell by a fully automatic hollow capsule manufacturing machine.

Embodiment 2a-2d

[0060] Examples 2a-2d Preparation of amoxicillin capsule contents (0.25g specification, 1000 capsules)

[0061] excipient

[0062] Preparation Process:

Embodiment 2a

[0064] 1. Mix amoxicillin and magnesium stearate evenly and set aside.

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