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30 results about "Hyperplasia Suppressor Gene" patented technology
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Detection method and kit of single nucleotide polymorphism locus rs7550536 of susceptibility gene of hypertension
InactiveCN101892311ASimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneIntein
The invention belongs to the molecular biology and medicine field and relates to a method for detecting a susceptibility gene of hypertension and a detection kit thereof. The invention provides a method for detecting a susceptibility gene of essential hypertension, comprising the step of detecting the genetype of a mitochondrion fusion gene 2(Mfn2) / hyperplasia suppressor gene (HSG) locus rs7550536. The individual, rs7550536 of which carries the T genetype has obviously higher susceptibility of hypertension than the common people. The invention also discloses the corresponding detection kit which contains a primer amplifying the locus rs7550536 and a primer amplifying the region of the locus rs7550536 contained in the No.14 intron of the Mfn2 gene. Being used for detecting the genetype of the locus rs7550536, the method is simple and practicable, fast and efficient and low in cost and provides a simple and direct new way for hypertension diagnosis and treatment.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Method for detecting rs2295281 locus of hypertension susceptibility gene and detection kit
InactiveCN101892305ASimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneMFN2
The invention belongs to the field of molecular biology and medicine, relating to a method for detecting a hypertension susceptibility gene and a detection kit thereof. The method for detecting a primary hypertension susceptibility gene comprises the following step of: detecting the genotype of the rs2295281 locus of a mitochondrion fusion gene 2(Mfn2) / a hyperplasia suppressor gene (HSG). The hypertension susceptibility of an rs2295281 individual with a genotype C is remarkably higher than that of the general public. The invention also discloses the corresponding detection kit. The detection kit contains a primer for amplifying the rs2295281 locus and can also contain the primer for amplifying a region comprising the rs2295281 locus in an eighth intron of the Mfn2 gene. The genotype of the rs2295281 locus is detected by adopting the method. The invention has simple and easy method, quick speed and high efficiency and low cost and provides a novel shortcut approach for diagnosing and treating hypertension.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Detection method and kit of locus rs2336384 of susceptibility gene of hypertension
InactiveCN101892302ASimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneIntein
The invention belongs to the molecular biology and medicine field and relates to a method for detecting a susceptibility gene of hypertension and a detection kit thereof. The invention provides a method for detecting a susceptibility gene of essential hypertension, comprising the step of detecting the genetype of a mitochondrion fusion gene 2(Mfn2) / hyperplasia suppressor gene (HSG) locus rs2336384. The individual, rs2336384 of which carries the G genetype has obviously higher susceptibility of hypertension than the common people. The invention also discloses the corresponding detection kit which contains a primer amplifying the locus rs2336384 and a primer amplifying the region of the locus rs2336384 contained in the No.2 intron of the Mfn2 gene. Being used for detecting the genetype of the locus rs2336384, the method is simple and practicable, fast and efficient and low in cost and provides a simple and direct new way for hypertension diagnosis and treatment.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Method for detecting mononucleotide polymorphism locus rs2236058 of hypertension susceptibility genes and detection kit
InactiveCN101886125ASimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneIntein
The invention belongs to the fields of molecular biology and medicine and relates to a method for detecting hypertension susceptibility genes and a detection kit thereof. The method for detecting the essential hypertension susceptibility genes comprises the step of detecting the gene type of the locus rs2236058 of mitochondria fusion genes 2 (Mfn2) / hyperplasia suppressor genes (HSG). People having the locus rs2236058 of the C gene type are more susceptible to the hypertension than the common crowd. The invention also discloses a relevant detection kit containing primers for amplifying the locus rs2236058 and primers for amplifying a zone containing the locus rs2236058 in the intron No.11 of the Mfn2 genes. The method is easy to operate, can be used for quickly and effectively detecting the gene type of the locus rs2236058 and has low cost, thereby being a simple new method for diagnosing and treating the hypertension.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Hypertension susceptibility relevant gene variation locus and detecting method thereof
InactiveCN104450884AMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneMFN2
The invention discloses a primary hypertension susceptibility relevant single-nucleotide locus and a method for detecting the single-nucleotide polymorphism of a primary hypertension relevant gene-mitofusin 2 gene(Mfn2 gene) / / hyperplasia suppressor gene (HSG), wherein the detecting method comprises detecting the genotypes of basic groups between -945bp and -946bp in a non-coding region at the 5' end of the individual mitofusin 2 (Mfn2) / hyperplasia suppressor gene (HSG). The invention also discloses a corresponding detecting kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Method for detecting mononucleotide polymorphism rs2236055 locus of hypertension susceptibility gene and kit thereof
InactiveCN101892298AIncreased susceptibilitySimple methodMicrobiological testing/measurementHyperplasia Suppressor GeneIntein
The invention belongs to the field of molecular biology and medicine, relating to a method for detecting primary hypertension susceptibility and a kit thereof. The method for detecting primary hypertension susceptibility comprises the following step of: detecting the genotype of the rs2236055 locus of a mitochondrion fusion gene 2(Mfn2) / a hyperplasia suppressor gene (HSG) of an individual. The hypertension susceptibility of the rs2236055 individual with an genotype A is remarkably higher than that of the general public. The invention also discloses the corresponding detection kit. The kit contains a primer for amplifying a primer of a region in the second intron of the Mfn2 gene. The genotype of the rs2236055 locus is detected by adopting the method. The invention has simple and easy method, quick speed and high efficiency and low cost and provides a novel shortcut approach for diagnosing and treating hypertension.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Hypertension susceptibility related gene locus and detection method thereof
InactiveCN104099329AMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneMFN2
The invention discloses a locus related to essential hypertension susceptibility, and discloses a method for detecting the single nucleotide polymorphism of an essential hypertension related gene mitofusin gene 2 (Mfn2) / hyperplasia suppressor gene (HSG). The method includes detecting the genotype of a 5' non-coding region-1248 locus of an individual mitofusin gene 2 (Mfn2) / hyperplasia suppressor gene (HSG). The invention also discloses a corresponding detection kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Method for detecting hypertension susceptible gene and detection kit
InactiveCN101892296AIncreased susceptibilitySimple methodMicrobiological testing/measurementHyperplasia Suppressor GeneMFN2
The invention belongs to the field of molecular biology and medicine and relates to a method for detecting susceptibility of essential hypertension and a kit thereof. The method for detecting the susceptibility of the essential hypertension comprises a step of detecting genotypes of mitochondrion fusion gene 2 (Mfn2) / hyperplasia suppressor gene (HSG) rs4240897 sites of an individual. For an individual of which the rs4240897 carries a G genotype, the susceptibility of hypertension of is obviously higher than that of general people. The invention further discloses a corresponding detection kit which contains a primer of which a No.2 amplification Mfn2 gene comprises a sub-area. By using the invention to detect the genotypes of the rs4240897 sites, the method is simple and easy, has a high speed, high efficiency and a low cost, and provides a new simple approach for hypertension diagnosis and treatment.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Method and kit for detecting rs2878677 locus of susceptibility gene of hypertension
InactiveCN101979657ASimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneMitochondrial fusion
The invention belongs to the field of molecular biology and medicine and relates to a method and a kit for detecting a susceptibility gene of hypertension. The invention provides a method for detecting a susceptibility gene of essential hypertension. The method comprises a step of detecting the gene type of a mitochondria fusion gene 2 (Mfn2) / hyperplasia suppressor gene (HSG) rs2878677 locus, wherein the hypertension susceptibility of an individual of which the rs2878677 locus carries a T gene type is obviously higher than that of common people. The invention also discloses a corresponding kit for detecting the susceptibility gene of hypertension. The kit comprises a primer for amplifying the rs2878677 locus and a primer for amplifying an area comprising the rs2878677 locus in the No.2 intron of Mfn2 gene. When used for detecting the gene type of the rs2878677 locus, the method is simple and is easy to implement, is fast and efficient, and has low cost and provides a simple and direct new way for the diagnosis and treatment of hypertension.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Primary hypertension susceptibility gene variation locus and detecting method thereof
InactiveCN104450690ASimple methodLow costMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneMFN2
The invention discloses a primary hypertension susceptibility relevant locus and a method for detecting the single-nucleotide polymorphism of a primary hypertension relevant gene- mitofusin 2 gene(Mfn2 gene) / hyperplasia suppressor gene (HSG), wherein the detecting method comprises detecting the genotypes of basic groups between -945bp and -946bp in a non-coding region at the 5' end of the individual mitofusin 2 (Mfn2) / hyperplasia suppressor gene (HSG). The invention also discloses a corresponding detecting kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Method for detecting rs4846085 locus of hypertension susceptibility gene and detection kit thereof
InactiveCN101892303ASimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneMFN2
The invention belongs to the field of molecular biology and medicine, relating to a method for detecting a hypertension susceptibility gene and a detection kit thereof. The method for detecting a primary hypertension susceptibility gene comprises the following step of: detecting the genotype of the rs4846085 locus of a mitochondrion fusion gene 2(Mfn2) / a hyperplasia suppressor gene (HSG). The hypertension susceptibility of an rs4846085 individual with a genotype T is remarkably higher than that of the general public. The invention also discloses the corresponding detection kit. The detection kit contains a primer for amplifying the rs4846085 locus and can also contain the primer for amplifying a region comprising the rs4846085 locus in a third intron of the Mfn2 gene. The genotype of the rs4846085 locus is detected by adopting the method. The invention has simple and easy method, quick speed and high efficiency and low cost and provides a novel shortcut approach for diagnosing and treating hypertension.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Detection method of single nucleotide polymorphism sites of hypertension susceptibility gene and kit thereof
InactiveCN101892297BSimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneMitochondrial fusion
The invention relates to the molecular biology and medicine field, in particular to a method for detecting essential hypertension susceptibility, which comprises the following steps of detecting the genotype at a site of rs3753579 of an individual mitochondrion fusion gene 2 (Mfn2) / hyperplasia suppressor gene (HSG), and thus judging whether the risk of the individual to suffer from essential hypertension is larger than that of common people. The invention also discloses a corresponding detection kit. By detecting the genotype at the site of rs3753579, the method is simple, practicable, fast, high efficient and low-cost, and provides a new short-cut way to the diagnosis and the treatment of hypertension.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Method for detecting locus rs873457 of hypertension susceptibility genes and detection kit
InactiveCN101886121BIncreased susceptibilitySimple methodMicrobiological testing/measurementHyperplasia Suppressor GeneGene type
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Method for detecting rs4846085 locus of hypertension susceptibility gene and detection kit thereof
InactiveCN101892303BSimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneMFN2
The invention belongs to the field of molecular biology and medicine, relating to a method for detecting a hypertension susceptibility gene and a detection kit thereof. The method for detecting a primary hypertension susceptibility gene comprises the following step of: detecting the genotype of the rs4846085 locus of a mitochondrion fusion gene 2(Mfn2) / a hyperplasia suppressor gene (HSG). The hypertension susceptibility of an rs4846085 individual with a genotype T is remarkably higher than that of the general public. The invention also discloses the corresponding detection kit. The detection kit contains a primer for amplifying the rs4846085 locus and can also contain the primer for amplifying a region comprising the rs4846085 locus in a third intron of the Mfn2 gene. The genotype of the rs4846085 locus is detected by adopting the method. The invention has simple and easy method, quick speed and high efficiency and low cost and provides a novel shortcut approach for diagnosing and treating hypertension.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Method and kit for detecting rs2878677 locus of susceptibility gene of hypertension
InactiveCN101979657BSimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneMitochondrial fusion
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
-2786 locus variant of mitochondrial fusion gene 2 and detection method of -2786 locus variant
InactiveCN105349638ASimple methodLow costMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneMitochondrial fusion
The invention discloses a -2786 locus variant of mitochondrial fusion gene 2 and a detection method of the -2786 locus variant, discloses a single nucleotide locus related to primary hypertension susceptibility and discloses a method for detecting single nucleotide polymorphism of primary hypertension related gene-mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG). The method includes: detecting genotype of -2786 locus in a 5' end non-coding region of mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG) of an individual. The invention further discloses a corresponding detection kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Use and detection kit of locus rs2336384 of susceptibility gene of hypertension
InactiveCN101892302BSimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneMitochondrial fusion
The invention belongs to the molecular biology and medicine field and relates to a method for detecting a susceptibility gene of hypertension and a detection kit thereof. The invention provides a method for detecting a susceptibility gene of essential hypertension, comprising the step of detecting the genetype of a mitochondrion fusion gene 2(Mfn2) / hyperplasia suppressor gene (HSG) locus rs2336384. The individual, rs2336384 of which carries the G genetype has obviously higher susceptibility of hypertension than the common people. The invention also discloses the corresponding detection kit which contains a primer amplifying the locus rs2336384 and a primer amplifying the region of the locus rs2336384 contained in the No.2 intron of the Mfn2 gene. Being used for detecting the genetype of the locus rs2336384, the method is simple and practicable, fast and efficient and low in cost and provides a simple and direct new way for hypertension diagnosis and treatment.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
-2500 locus variant of mitochondrial fusion gene 2 and detection method of -2500 locus variant
InactiveCN105349635ASimple methodLow costMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneMFN2
The invention discloses a single nucleotide locus related to primary hypertension susceptibility and discloses a method for detecting single nucleotide polymorphism of primary hypertension related gene-mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG). The method includes: detecting genotype of a region of -2500 locus of a 5' end non-coding region of mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG) of an individual. The invention further discloses a corresponding detection kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Hypertension susceptibility gene locus rs61776496 and detection method thereof
InactiveCN105349639ASimple methodLow costMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneMFN2
The invention discloses a hypertension susceptibility gene locus rs61776496 and a detection method thereof, discloses a single nucleotide locus related to primary hypertension susceptibility and discloses a method for detecting single nucleotide polymorphism of primary hypertension related gene-mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG). The method includes: detecting genotype of mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG) rs61776496 locus of an individual, wherein rs61776496 carries an individual of C genotype, and hypertension susceptibility is higher than that of common people. The invention further discloses a corresponding detection kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Method for detecting hypertension susceptible gene and detection kit
InactiveCN101892296BIncreased susceptibilitySimple methodMicrobiological testing/measurementHyperplasia Suppressor GenePhysiology
The invention belongs to the field of molecular biology and medicine and relates to a method for detecting susceptibility of essential hypertension and a kit thereof. The method for detecting the susceptibility of the essential hypertension comprises a step of detecting genotypes of mitochondrion fusion gene 2 (Mfn2) / hyperplasia suppressor gene (HSG) rs4240897 sites of an individual. For an individual of which the rs4240897 carries a G genotype, the susceptibility of hypertension of is obviously higher than that of general people. The invention further discloses a corresponding detection kit which contains a primer of which a No.2 amplification Mfn2 gene comprises a sub-area. By using the invention to detect the genotypes of the rs4240897 sites, the method is simple and easy, has a high speed, high efficiency and a low cost, and provides a new simple approach for hypertension diagnosis and treatment.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Hypertension susceptibility relevant gene locus and detecting method thereof
InactiveCN104450689AMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneNucleotide
The invention discloses a primary hypertension susceptibility relevant single-nucleotide locus and a method for detecting the single-nucleotide polymorphism of a primary hypertension relevant gene-mitofusin 2 gene(Mfn2 gene) / hyperplasia suppressor gene (HSG), wherein the detecting method comprises detecting the genotypes of basic groups between -945bp and -946bp in a non-coding region at the 5' end of the individual mitofusin 2 (Mfn2) / hyperplasia suppressor gene (HSG). The invention also discloses a corresponding detecting kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
-2380 locus variant of mitochondrial fusion gene 2 and detection method thereof
InactiveCN105349631ASimple methodLow costMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneMFN2
The invention discloses a -2380 locus variant of mitochondrial fusion gene 2 and a detection method thereof, discloses a single nucleotide locus related to primary hypertension susceptibility and discloses a method for detecting single nucleotide polymorphism of primary hypertension related gene-mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG). The method includes: detecting genotype of a -2380 locus in a 5' end non-coding region of the mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG) of an individual. The invention further discloses a corresponding detection kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Method for detecting rs2295281 locus of hypertension susceptibility gene and detection kit
InactiveCN101892305BSimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneMitochondrial fusion
The invention belongs to the field of molecular biology and medicine, relating to a method for detecting a hypertension susceptibility gene and a detection kit thereof. The method for detecting a primary hypertension susceptibility gene comprises the following step of: detecting the genotype of the rs2295281 locus of a mitochondrion fusion gene 2(Mfn2) / a hyperplasia suppressor gene (HSG). The hypertension susceptibility of an rs2295281 individual with a genotype C is remarkably higher than that of the general public. The invention also discloses the corresponding detection kit. The detection kit contains a primer for amplifying the rs2295281 locus and can also contain the primer for amplifying a region comprising the rs2295281 locus in an eighth intron of the Mfn2 gene. The genotype of the rs2295281 locus is detected by adopting the method. The invention has simple and easy method, quick speed and high efficiency and low cost and provides a novel shortcut approach for diagnosing and treating hypertension.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Variation site of hypertension susceptibility gene Mfn2 and detecting method of variation site
InactiveCN105349628ASimple methodLow costMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneNucleotide
The invention discloses a single nucleotide site related to essential hypertension susceptibility and a method for detecting single nucleotide polymorphism of mitofusin 2 (Mfn2) / hyperplasia suppressor gene (HSG) which is related to essential hypertension. The method includes: detecting the genotype of a region between the 5'non-coding region-2517 site and the 5'non-coding region-2518 site of single Mfn2 and HSG. The invention further discloses a corresponding detection kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
-2459 locus variant of mitochondrial fusion gene 2 and detection method thereof
InactiveCN105349633ASimple methodLow costMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneMitochondrial fusion
The invention discloses a -2459 locus variant of mitochondrial fusion gene 2 and a detection method thereof, discloses a single nucleotide locus related to primary hypertension susceptibility and discloses a method for detecting single nucleotide polymorphism of primary hypertension related gene-mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG). The method includes: detecting genotype of a -2459 locus in a 5' end non-coding region of the mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG) of an individual. The invention further discloses a corresponding detection kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Hypertension susceptibility gene locus rs11553681 and detection method thereof
InactiveCN105349630ASimple methodLow costMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneMitochondrial fusion
The invention discloses a single nucleotide locus related to primary hypertension susceptibility and discloses a method for detecting single nucleotide polymorphism of primary hypertension related gene-mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG). The method includes: detecting genotype of mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG) rs11553681 locus of an individual, wherein rs11553681 carries an individual of C genotype, and hypertension susceptibility is higher than common people. The invention further discloses a corresponding detection kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Method for detecting mononucleotide polymorphism rs2236055 locus of hypertension susceptibility gene and kit thereof
InactiveCN101892298BIncreased susceptibilitySimple methodMicrobiological testing/measurementHyperplasia Suppressor GeneMitochondrial fusion
The invention belongs to the field of molecular biology and medicine, relating to a method for detecting primary hypertension susceptibility and a kit thereof. The method for detecting primary hypertension susceptibility comprises the following step of: detecting the genotype of the rs2236055 locus of a mitochondrion fusion gene 2(Mfn2) / a hyperplasia suppressor gene (HSG) of an individual. The hypertension susceptibility of the rs2236055 individual with an genotype A is remarkably higher than that of the general public. The invention also discloses the corresponding detection kit. The kit contains a primer for amplifying a primer of a region in the second intron of the Mfn2 gene. The genotype of the rs2236055 locus is detected by adopting the method. The invention has simple and easy method, quick speed and high efficiency and low cost and provides a novel shortcut approach for diagnosing and treating hypertension.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Method for detecting mononucleotide polymorphism locus rs2236058 of hypertension susceptibility genes and detection kit
InactiveCN101886125BSimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneMitochondrial fusion
The invention belongs to the fields of molecular biology and medicine and relates to a method for detecting hypertension susceptibility genes and a detection kit thereof. The method for detecting the essential hypertension susceptibility genes comprises the step of detecting the gene type of the locus rs2236058 of mitochondria fusion genes 2 (Mfn2) / hyperplasia suppressor genes (HSG). People having the locus rs2236058 of the C gene type are more susceptible to the hypertension than the common crowd. The invention also discloses a relevant detection kit containing primers for amplifying the locus rs2236058 and primers for amplifying a zone containing the locus rs2236058 in the intron No.11 of the Mfn2 genes. The method is easy to operate, can be used for quickly and effectively detecting the gene type of the locus rs2236058 and has low cost, thereby being a simple new method for diagnosing and treating the hypertension.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Detection method and kit of single nucleotide polymorphism locus rs7550536 of susceptibility gene of hypertension
InactiveCN101892311BSimple methodLow costMicrobiological testing/measurementHyperplasia Suppressor GeneIntein
The invention belongs to the molecular biology and medicine field and relates to a method for detecting a susceptibility gene of hypertension and a detection kit thereof. The invention provides a method for detecting a susceptibility gene of essential hypertension, comprising the step of detecting the genetype of a mitochondrion fusion gene 2(Mfn2) / hyperplasia suppressor gene (HSG) locus rs7550536. The individual, rs7550536 of which carries the T genetype has obviously higher susceptibility of hypertension than the common people. The invention also discloses the corresponding detection kit which contains a primer amplifying the locus rs7550536 and a primer amplifying the region of the locus rs7550536 contained in the No.14 intron of the Mfn2 gene. Being used for detecting the genetype of the locus rs7550536, the method is simple and practicable, fast and efficient and low in cost and provides a simple and direct new way for hypertension diagnosis and treatment.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
Hypertension susceptibility gene locus rs11587948 and detection method thereof
InactiveCN105349629ASimple methodLow costMicrobiological testing/measurementDNA/RNA fragmentationHyperplasia Suppressor GeneMFN2
The invention discloses a single nucleotide locus related to primary hypertension susceptibility and discloses a method for detecting single nucleotide polymorphism of primary hypertension related gene-mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG). The method includes: detecting genotype of mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG) rs11587948 locus of an individual, wherein rs11587948 carries an individual of C genotype, and hypertension susceptibility is higher than common people. The invention further discloses a corresponding detection kit.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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