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Hypertension susceptibility gene locus rs11587948 and detection method thereof

An essential hypertension and locus technology, applied in the fields of molecular biology and medicine, can solve problems such as less research, decreased expression, abnormal expression regulation, etc.

Inactive Publication Date: 2016-02-24
BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the main characteristic of Mfn2 gene in the blood vessels and leukocytes of patients with essential hypertension and spontaneously hypertensive rats is the decreased expression, this should be due to the abnormality of its expression regulation. few

Method used

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  • Hypertension susceptibility gene locus rs11587948 and detection method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The rs11587948 site of the essential hypertension susceptibility gene MFn2 gene was detected by sequencing method. 30 cases of each of the above hypertension cases and control groups were selected for sequencing to determine the genotype of the rs11587948 locus.

[0029] 1. Experimental method

[0030] The above PCR primers were still used as primers for PCR sequencing, and the amplified products were directly sequenced after purification. The sequencing instrument is ABI's 3130xl genetic analyzer, which is analyzed with sequenceanalysis5.2 analysis software, and the results can also be viewed with chromas.

[0031] 2. Experimental results

[0032] The screenshot of the sequencing result is as follows: figure 1 shown.

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Abstract

The invention discloses a single nucleotide locus related to primary hypertension susceptibility and discloses a method for detecting single nucleotide polymorphism of primary hypertension related gene-mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG). The method includes: detecting genotype of mitochondrial fusion gene 2 (Mfn2) or hyperplasia suppressor gene (HSG) rs11587948 locus of an individual, wherein rs11587948 carries an individual of C genotype, and hypertension susceptibility is higher than common people. The invention further discloses a corresponding detection kit.

Description

technical field [0001] The present invention relates to the fields of molecular biology and medicine. More specifically, it involves detection of the single nucleotide polymorphism (Singlenucleotidepolymorphism, SNP) site rs11587948 of human mitochondrial fusion gene 2 (Mitofusin2, Mfn2gene) and its correlation with essential hypertension. The invention also relates to a kit for detecting the SNP site. Background technique [0002] Essential hypertension (Essential hypertension, EH) is a common and frequent multifactorial and polygenic disease caused by environmental and genetic factors, which has a great impact on human health. With the development of molecular medicine, more than 150 hypertension-related genes have been discovered, but the pathogenesis of EH is still not completely clear, and the early diagnosis and prevention of hypertension have not been fully resolved. EH is the result of the joint action of genetic factors and the environment, and 30%-60% of changes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 魏永祥王佐广孙东东彭晓云靳飞刘洁琳李闯李梅刘雅牛秋丽
Owner BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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