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45results about How to "Absorbed less rapidly" patented technology
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Phenyl guanidine sodium channel blockers
InactiveUS6858615B2Increased mucociliary clearanceAbsorbed less rapidlyBiocideSenses disorderStructural variableGuanidine
The present invention relates to a compound represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are as defined herein. The compounds are useful for blocking sodium channels.
Owner:PARION SCI DURHAM NC
Phenolic guanidine sodium channel blockers
InactiveUS6858614B2Increased mucociliary clearanceAbsorbed less rapidlyBiocideSenses disorderGuanidineSodium channel blocker
The present invention relates to compounds represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are defined herein. The compounds are useful for blocking sodium channels.
Owner:PARION SCI DURHAM NC
Sodium channel blockers
InactiveUS6903105B2More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsSenses disorderTreatment useCalcium channel blocker
The present invention relates to pyrazinoylguanidine compounds represented by formula (I): where at least one of R3 and R4 is a group represented by formula (A): where the other structural groups are defined herein. The present invention also includes a variety of methods of treatment using these sodium channel blockers.
Owner:PARION SCI DURHAM NC
Sodium channel blockers
InactiveUS7192958B2More potent and/or absorbed less rapidlyLess reversibleBiocideSenses disorderChannel blockerCalcium channel blocker
Owner:PARION SCI DURHAM NC
Sodium channel blockers
InactiveUS7186833B2More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsSenses disorderOrganic chemistryMedicinal chemistry
Owner:PARION SCI DURHAM NC
Sodium channel blockers
InactiveUS7192959B2More potent and/or absorbed less rapidlyLess reversibleBiocideSenses disorderStructural variableStereochemistry
Owner:PARION SCI DURHAM NC
Cyclic pyrazinoylguanidine sodium channel blockers
ActiveUS7317013B2More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsSenses disorderChannel blockerStructural variable
Owner:PARION SCI DURHAM NC
Soluble amide & ester pyrazinoylguanidine sodium channel blockers
ActiveUS7399766B2More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsBiocideChannel blockerStructural variable
Owner:PARION SCI DURHAM NC
Alaphatic pyrazinoylguanidine sodium channel blockers
ActiveUS7375107B2More potent and/or absorbed less rapidlyLess reversibleBiocideOrganic active ingredientsDiseasePyrazine
Owner:PARION SCI DURHAM NC
Capped pyrazinoylguanidine sodium channel blockers
InactiveUS7807834B2Prolonged pharmacodynamic half-lifeMore potent and/or absorbed less rapidlySenses disorderNervous disorderChannel blockerCalcium channel blocker
Owner:PARION SCI DURHAM NC
Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
ActiveUS20080090841A1More specificLess reversibleAntibacterial agentsOrganic active ingredientsOtic AgentsOsmolyte
The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
Owner:PARION SCI DURHAM NC
Sodium channel blockers
InactiveUS20060142306A1More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsSenses disorderTreatment useChemistry
Owner:CYFI
Alaphatic pyrazinoylguanidine sodium channel blockers
ActiveUS20050080092A1Absorbed less rapidlyMore potentOrganic active ingredientsSenses disorderChannel blockerTreatment use
Owner:PARION SCI DURHAM NC
Aliphatic amide and ester pyrazinoylguanidine sodium channel blockers
InactiveUS7956059B2More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsSenses disorderCombinatorial chemistryChannel blocker
The present invention relates to pyrazinoylguanidine compounds represented by formula (I):where the structural variables are defined herein. The compounds are useful as, for example, sodium channel blockers.
Owner:PARION SCI DURHAM NC
Poly aromatic pyrazinoylguanidine sodium channel blockers
ActiveUS8124607B2More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsSenses disorderChannel blockerTreatment use
Owner:PARION SCI DURHAM NC
Soluble amide & ester pyrazinoylguanidine sodium channel blockers
ActiveUS20060040954A1More potent and/or absorbed less rapidlyLess reversibleBiocideOrganic active ingredientsChannel blockerTreatment use
Owner:PARION SCI DURHAM NC
Cyclic amide and ester pyrazinoylguanidine sodium channel blockers
ActiveUS8143256B2More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsSenses disorderCombinatorial chemistryChannel blocker
The present invention provides compounds represented by formula (I):where the structural variables are defined herein. The compound of the present invention are useful as sodium channel blockers.
Owner:PARION SCI DURHAM NC
Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
InactiveUS8058278B2More specificAbsorbed less rapidlyAntibacterial agentsOrganic active ingredientsDiseaseOsmolyte
Owner:PARION SCI DURHAM NC
Phenyl substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity
ActiveUS8163758B2More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsSenses disorderDiseaseAgonist
Owner:PARION SCI DURHAM NC
New capped pyrazinoylguanidine sodium channel blockers
InactiveUS20070032509A1Less surfaceLess reversibleSenses disorderNervous disorderChemistryTreatment use
Owner:PARION SCI DURHAM NC
Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
Owner:PARION SCI DURHAM NC
Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity
ActiveUS8324218B2More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsSenses disorderDiseaseSinusitis
Owner:PARION SCI DURHAM NC
Cyclic pyrazinoylguanidine sodium channel blockers
ActiveUS20050059676A1More potentLess reversibleOrganic active ingredientsSenses disorderChannel blockerTreatment use
Owner:PARION SCI DURHAM NC
Cyclic Amide & Ester Pyrazinoylganidine Sodium Channel Blockers
ActiveUS20080096896A1More potentLess reversibleOrganic active ingredientsSenses disorderChannel blockerTreatment use
Owner:PARION SCI DURHAM NC
Capped pyrazinoylguanidine sodium channel blockers
ActiveUS20050228182A1More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsSenses disorderChannel blockerTreatment use
Owner:PARION SCI DURHAM NC
Soluble amide & ester pyrazinoylguanidine sodium channel blockers
InactiveUS20090324724A1More potent and/or absorbed less rapidlyLess reversibleOrganic active ingredientsPowder deliveryChannel blockerTreatment use
Owner:PARION SCI DURHAM NC
Sodium channel blockers
InactiveUS20050113390A1More potentLess reversibleOrganic active ingredientsSenses disorderChemistryTreatment use
Owner:PARION SCI DURHAM NC
Sodium channel blockers
InactiveUS20050113389A1More potentLess reversibleOrganic active ingredientsSenses disorderChemistryTreatment use
Owner:PARION SCI DURHAM NC
Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
Owner:PARION SCI DURHAM NC
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