The invention relates to the field of milk powder production, and particularly discloses a milk powder formula helpful for delaying senescence and preventing hypertension, hyperglycemia and hyperlipidemia and a preparation method thereof, the raw materials of the formula milk powder comprise main materials and auxiliary materials, and the raw materials of the formula milk powder further comprise nutrient substances; the main materials comprise skim milk powder and whole milk powder. The radix polygonati officinalis extract, the radix puerariae extract, the folium mori extract and the rhizoma polygonati extract are all medicinal and edible components, so that on one hand, a health-care effect can be provided for a human body, and on the other hand, three highs can be effectively prevented; through the arrangement of nutrient substances, daily nutrient elements can be effectively provided for people, and retinyl acetate, cholecalciferol, dl-alpha-tocopheryl acetate, pyridoxine hydrochloride and L-sodium ascorbate can also provide vitamins required by a schedule for a human body and have a certain effect of delaying senescence.