The embodiment of the invention provides a touch substrate, a preparation method and a driving method thereof and a touch display panel. The touch substrate comprises a plane part and at least one bending part, the bending part extends from the edge of the plane part and is bent to the side edge of the plane part, the plane part is provided with a main touch module with a double-layer electrode structure, and the bending part is provided with a side touch module with a single-layer electrode structure. According to the present invention, a combined electrode structure of a double-layer electrode structure and a single-layer electrode structure is adopted, namely, the main touch module of the plane part adopts a double-layer electrode structure, the side touch module of the bending part is of a single-layer electrode structure, so that the corner wrinkles caused by bending are eliminated, the bending of two adjacent edges, three adjacent edges and four adjacent edges can be achieved, the touch effect and the reliability of a corner area are guaranteed, and the design complexity and the preparation process difficulty of the touch substrate are reduced to the maximum extent.