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46results about How to "High tolerability" patented technology
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Indanyloxydihydrobenzofuranylacetic acids
InactiveUS20140163025A1Improve effectivenessImprove stabilityBiocideOrganic chemistryDiabetes mellitusDisease
The present invention relates to compounds of general formula I,wherein the groups (Het)Ar and R1 are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxydihydrobenzofuranylacetic acids
The present invention relates to compounds of general formula I,wherein the group (Het)Ar is defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Owner:BOEHRINGER INGELHEIM INT GMBH
New indanyloxydihydrobenzofuranylacetic acids
ActiveUS20130252937A1Improve effectivenessImprove stabilityBiocideOrganic chemistryDiseaseDiabetes mellitus
The present invention relates to compounds of general formula I,wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxyphenylcyclopropanecarboxylic acids
ActiveUS20130324514A1Improve effectivenessImprove stabilityBiocideMetabolism disorderDiseaseCarboxylic acid
The present invention relates to compounds of general formula I,wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxyphenylcyclopropanecarboxylic acids
ActiveUS8633182B2Improve effectivenessImprove stabilityBiocideOrganic compound preparationDiseaseCarboxylic acid
The present invention relates to compounds of general formula I,wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxydihydrobenzofuranylacetic acids
ActiveUS8642585B2Improve effectivenessImprove stabilityBiocideOrganic chemistryDiseaseDiabetes mellitus
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxydihydrobenzofuranylacetic acids
ActiveUS20140221349A1Improve effectivenessImprove stabilityBiocideOrganic chemistryDiabetes mellitusAcetic acid
Compounds of general formula Iwherein the group R1 is defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Owner:BOEHRINGER INGELHEIM INT GMBH
Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
ActiveUS20190389815A1Improve effectivenessImprove stabilityOrganic active ingredientsOrganic chemistryDiseaseDiabetes types
The present invention relates to compounds of general formula I,wherein the groups R, R1, R2, R3, m and n are defined herein, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Owner:BOEHRINGER INGELHEIM INT GMBH
Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
ActiveUS10538490B2Improve effectivenessImprove stabilityOrganic chemistryMetabolism disorderDiseaseDiabetes mellitus
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxydihydrobenzofuranylacetic acids
ActiveUS20160235706A1Improve effectivenessImprove stabilityOrganic chemistryMetabolism disorderDiabetes mellitusDisease
Owner:BOEHRINGER INGELHEIM INT GMBH
Azabenzimidazole derivatives
ActiveUS20160039846A1Improve stabilityImprove effectivenessBiocideOrganic chemistryDiseaseProtein kinase C
The present invention relates to compounds of general formula I,wherein the group R1, R2, X, Y and Z are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Owner:BOEHRINGER INGELHEIM INT GMBH
Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
ActiveUS10603317B2Improve effectivenessImprove stabilityOrganic active ingredientsOrganic chemistryDiseaseDiabetes mellitus
Owner:BOEHRINGER INGELHEIM INT GMBH
New indanyloxydihydrobenzofuranylacetic acids
ActiveUS20130289074A1Improve effectivenessImprove stabilityBiocideOrganic chemistryDiseaseStereochemistry
The present invention relates to compounds of general formula I,wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxyphenylcyclopropanecarboxylic acids
ActiveUS20150148347A1Improve effectivenessImprove stabilityBiocideOrganic chemistryDiseaseCarboxylic acid
A compound of formula I,wherein the groups R1, R2, R3, X, m, and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
Owner:BOEHRINGER INGELHEIM INT GMBH
Azabenzimidazole derivatives
ActiveUS9492436B2Improve stabilityLow toxicityOrganic active ingredientsOrganic chemistryDiseaseDiabetes mellitus
Owner:BOEHRINGER INGELHEIM INT GMBH
Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications
InactiveUS7700612B2Increase biological and bioavailabilityMaintaining inherent activityBiocideOrganic chemistryEster prodrugBioavailability
Owner:NANTBIOSCI +1
Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
ActiveUS20170037040A1Improve effectivenessImprove stabilityOrganic active ingredientsOrganic chemistryDiseaseCarboxylic acid
The present invention relates to compounds of general formula I,wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxyphenylcyclopropanecarboxylic acids
ActiveUS9308194B2Improve effectivenessImprove stabilityOrganic chemistryPeptide/protein ingredientsDiseaseCarboxylic acid
Owner:BOEHRINGER INGELHEIM INT GMBH
New azabenzimidazole derivatives
The present invention relates to compounds of general formula I,wherein the group R1, R2, X, Y and z are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxydihydrobenzofuranylacetic acids
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxydihydrobenzofuranylacetic acids
Owner:BOEHRINGER INGELHEIM INT GMBH
Triazole benzamide derivatives as gpr142 agonists
ActiveUS20210267947A1Improve stabilityImprove effectivenessOrganic active ingredientsOrganic chemistryDiseasePharmacometrics
The present invention relates to compounds of general formula I,wherein the groups R1, R2, R3, R4, n and m are as defined herein, which have valuable pharmacological properties, in particular bind to the GPR142 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as type 2 diabetes.
Owner:BOEHRINGER INGELHEIM INT GMBH
Azabenzimidazole derivatives
ActiveUS10053471B2Improve stabilityGood curative effectOrganic active ingredientsOrganic chemistryDiseaseProtein kinase C
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
ActiveUS9617251B2Improve effectivenessImprove stabilityOrganic active ingredientsOrganic chemistryDiseaseCarboxylic acid
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
ActiveUS20180208560A1Improve effectivenessImprove stabilityOrganic active ingredientsOrganic chemistryDiseaseDiabetes mellitus
The present invention relates to compounds of formula I,wherein the groups R, R1, R2, R3, m and n are defined herein, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
Owner:BOEHRINGER INGELHEIM INT GMBH
Triazole benzamide derivatives as GPR142 agonists
ActiveUS11179371B2Improve stabilityImprove effectivenessOrganic active ingredientsOrganic chemistryDiseasePharmacometrics
The present invention relates to compounds of general formula I,wherein the groups R1, R2, R3, R4, n and m are as defined herein, which have valuable pharmacological properties, in particular bind to the GPR142 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as type 2 diabetes.
Owner:BOEHRINGER INGELHEIM INT GMBH
Azabenzimidazole derivatives
ActiveUS9422312B2Improve stabilityImprove effectivenessOrganic active ingredientsOrganic chemistryDiseaseProtein kinase C
Owner:BOEHRINGER INGELHEIM INT GMBH
Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
ActiveUS20190352266A1Improve effectivenessImprove stabilityOrganic chemistryMetabolism disorderDiseaseMedicine
The present invention relates to compounds of general formula I,wherein the groups R, R1, R2, R3, m and n are defined herein, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Owner:BOEHRINGER INGELHEIM INT GMBH
Indanyloxydihydrobenzofuranylacetic acids
Compounds of general formula Iwherein the group R1 is defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
Owner:BOEHRINGER INGELHEIM INT GMBH
Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
ActiveUS10793530B2Improve effectivenessImprove stabilityOrganic active ingredientsOrganic chemistryDiseaseReceptor
Owner:BOEHRINGER INGELHEIM INT GMBH
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