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40results about How to "Reduce R&D Risk" patented technology

Method for determining in-vitro dissolution of felodipine sustained-release tablets

ActiveCN112526055AOvercome cohesionEnsure physiological temperatureComponent separationDissolutionPharmaceutical Substances
The invention belongs to the technical field of pharmaceutical analysis, and discloses a method for determining in-vitro dissolution of felodipine sustained-release tablets, wherein the method comprises the steps: dissolving out felodipine sustained-release tablets by using a two-chamber model experiment device, dissolving out a pH 6.8 phosphate buffer solution of which the medium is 0.3% lauryl sodium sulfate, and putting the felodipine sustained-release tablets into a rotating basket at the rotating basket rotating speed of 100 rpm; filtering the dissolution solution by a filter membrane, continuously extracting the dissolution solution, and measuring the concentration of the felodipine in the dissolution solution at the extraction speed of the dissolution solution and the supplementingspeed of a dissolution medium of 5-12 mL/min until the dissolution of the felodipine sustained-release tablets is completed; and determining the average dissolution concentration of the felodipine inthe dissolution solution at different time points by adopting a high performance liquid chromatography. According to the in-vitro dissolution method, the in-vivo absorption process is simulated, so that the accuracy of the in-vitro dissolution experiment is guaranteed, the consistency of a dissolution curve measured by the in-vitro dissolution experiment and the in-vivo absorption process is realized, and a guarantee is provided for realizing good prediction of the bioequivalence of a human body.
Owner:HUNAN HUIZE BIO PHARMA CO LTD

Method for measuring in-vitro dissolution rate of nifedipine controlled release tablets

The invention belongs to the technical field of medicine analysis, and discloses a method for measuring the in-vitro dissolution rate of nifedipine controlled release tablets, which comprises the following specific steps: (1) a dissolution medium enters a dissolution container from a liquid inlet, the nifedipine controlled release tablets in the dissolution container are dissolved out, and a dissolution liquid dissolved with nifedipine is output to a sampling device to complete sampling; and (2) the concentration of nifedipine in the collected sample is measured by using a high performance liquid chromatograph, an average differential dissolution curve graph between the concentration of nifedipine and the dissolution time is drawn, and a cumulative dissolution curve graph between the cumulative dissolution mass fraction and the dissolution time is obtained according to the differential dissolution relation. According to the method, the dissolution concentration of the nifedipine controlled-release tablets is measured by simulating the dynamic continuous process of in-vivo dissolution and absorption, different nifedipine controlled-release tablets are distinguished by quality, so that the BE experiment passing rate of the nifedipine controlled-release tablets is improved, and the research and development risk is reduced.
Owner:HUNAN HUIZE BIO PHARMA CO LTD

In-vitro dissolution method of mirabegron sustained release tablet

PendingCN114858986ADistinguish quality differencesDistinguish process differencesComponent separationTesting medicinal preparationsProlonged-release tabletPhysical chemistry
The invention belongs to the technical field of pharmaceutical analysis, and particularly discloses an in-vitro dissolution method of mirabegron sustained release tablets. A flow cell method is adopted, a dissolution medium is conveyed to a dissolution container through a constant flow pump, the medicine is continuously pumped out of the dissolution container along with the dissolution medium at the same constant flow speed in the swelling and erosion processes, and sampling is conducted at intervals at a fixed time point; and detecting the mirabegron sample concentration at each time point by using a high performance liquid chromatograph to obtain a mirabegron dissolution curve and an in-vivo and in-vitro correlation curve, and predicting the bioequivalence of the tested preparation and the reference preparation. The dissolution method adopted by the invention can truly simulate in-vivo release and absorption processes, realizes in-vivo and in-vitro correlation of drugs, and combines f2 factors to doubly analyze preparation differences, so that quality differences and process differences between a reference preparation and different tested preparations can be effectively distinguished, and similarity and quality consistency evaluation of mirabegron sustained release preparations is realized.
Owner:HUNAN HUIZE BIO PHARMA CO LTD

Method for quickly screening saccharification and/or ageing resisting substances

The invention provides a method for quickly screening saccharification and/or ageing resisting substances. The method comprises the steps of feeding fruit flies of 1-3 days old with a cane sugar aqueous solution containing potential active substances to be tested, besides, using the fruit flies only fed with a cane sugar aqueous solution as a control group, then performing hungry treatment on thetwo groups of the fruit flies, finally, performing feeding with pyruvic aldehyde, and counting the death quantity of the fruit flies at intervals until the two groups of the fruit flies are dead completely; and when the mortality rate of the fruit flies in the control group is 40%-60%, performing statistics on the survival condition of the fruit flies in the experiment group, judging whether the potential active substances to be tested can prolong the survival time of the fruit flies or not, and if yes, determining that the substances are saccharification and/or ageing resisting substances. Within a 7-day experiment period, compared with a conventional cell model and other animal models, at an extremely low economy cost, whether one substance has activity of resisting saccharification andageing can be determined, and a prominent platform is provided for large-scale high-throughput screening of active substances for resisting diabetes and resisting ageing relevant diseases.
Owner:上海普佑生物医药有限公司

Multifunctional display platform of direct-drive A/C-axis double-angle numerical control universal milling head

A multifunctional display platform of a direct-drive A / C-axis double-angle numerical control universal milling head comprises a pedestal, a stand column and a head body, wherein the pedestal is welded; the stand column is a hollow pipe, and the lower end of the stand column is connected with the pedestal through a bolt while the upper end thereof is abutted with the head body through axle hole clearance fit; a wire groove communicated with the inner hole of the stand column is arranged on the pedestal corresponding to the mounting position of the stand column; a rectangular groove is arranged at the side of the pedestal; and the head body is a hollow welded cubic structure or a regular trigone column assembled by a welding bracket, a protection piece and a connection piece. The multifunctional display platform of the direct-drive A / C-axis double-angle numerical control universal milling head has the following advantages of: (1) replacing the machine tool, independently displaying the functions of the functional components, and saving the cost; (2) being convenient for assembly and transportation because the stand column and the pedestal are fixed through a bolt, and the stand column and the head body are combined through a joint and reducing the time and cost; (3) shortening the development period and reducing the development risk; and (4) occupying small area, wherein three or four multifunctional display platforms of the direct-drive A / C-axis double-angle numerical control universal milling head can be arranged in the area occupied by one machine tool.
Owner:SHENYANG MACHINE TOOLGRP RES & DESIGN INST CO LTD SHANGHAI BRANCH

Method for determining the in vitro dissolution of felodipine sustained-release tablets

ActiveCN112526055BOvercome cohesionEnsure physiological temperatureComponent separationProlonged-release tabletDissolution
The invention belongs to the technical field of drug analysis, and discloses a method for measuring the in vitro dissolution of felodipine sustained-release tablets. The felodipine sustained-release tablets are dissolved using a two-chamber model experimental device, and the dissolution medium is 0.3% sodium lauryl sulfate. pH 6.8 phosphate buffer solution, felodipine slow-release tablets are placed in the rotating basket, the rotating speed of the rotating basket is 100 rpm, the stripping solution is continuously extracted after the stripping solution is filtered through the filter membrane, and the extraction speed of the stripping solution is the same as that of the dissolution medium. The replenishment rate was 5-12 mL / min to measure the concentration of felodipine in the dissolution liquid until the dissolution of the felodipine sustained-release tablet was completed; the average dissolution concentration of felodipine in the dissolution liquid at different time points was measured by high performance liquid chromatography . The in vitro dissolution method of the present invention ensures the accuracy of the in vitro dissolution test by simulating the in vivo absorption process, realizes that the dissolution curve determined by the in vitro dissolution test is consistent with the in vivo absorption process, and provides guarantee for realizing good prediction of human bioequivalence.
Owner:HUNAN HUIZE BIO PHARMA CO LTD

A method for determining the energy of electric vehicle power battery under cycle conditions

ActiveCN106202972BSolve the problem that the cruising range is difficult to meet the design requirementsReduce R&D RiskInformaticsSpecial data processing applicationsPower batteryEngineering
The invention relates to a method for determining energy of a power battery of an electric automobile under circulating working conditions. The method comprises the following steps of breaking down each circulating working condition of the pure electric automobile into a uniform speed working condition, an acceleration working condition and a brake working condition; respectively determining the energy requirements under each of the uniform speed working condition and acceleration working condition; determining the driving energy consumption of the whole automobile under the uniform speed working condition and acceleration working condition, so as to obtain the energy requirement of a power battery pack. The method has the advantages that in the early design period of the pure electric automobile, the energy of the power battery is calculated according to the endurance mileage requirement under the circulating working condition, the endurance mileage requirement of the whole automobile is guaranteed, the research and development risk of a project is decreased, and the defect of low calculation accuracy of energy of power battery according to endurance mileage requirement under the uniform speed working condition is overcome.
Owner:芜湖泰瑞汽车有限公司

Vehicle sound insulation performance analysis method, system and medium

ActiveCN113255060BAccurately evaluate the sound insulation levelImprove work efficiencyGeometric CADSustainable transportationSound sourcesEngineering
The invention discloses a vehicle sound insulation performance analysis method, system and medium, and relates to the technical field of vehicle sound insulation detection, comprising the following steps: collecting a sound source imaging map and a sound source spectrum map of a vehicle to be tested in a preset state; collecting the The sound insulation contribution of the vehicle to be tested; obtain the weak position of the sound insulation of the vehicle to be tested according to the sound source imaging map and the sound source spectrum; obtain the mapping table of the sound insulation contribution and the sound insulation requirement; according to the sound insulation contribution Quantities and the mapping table to obtain the sound insulation requirement level of the part. The present invention is carried out in a noise-absorbing environment, which avoids most of the sounds caused by the influence of the vehicle glass from being injected into the vehicle through the glass. The package analyzes the contribution of sound insulation, with high work efficiency and good detection accuracy, which realizes lightweight products, low-cost research and development, and ultimately shortens product development cycles and reduces research and development risks.
Owner:DONGFENG MOTOR GRP

Multifunctional display platform of direct-drive A/C-axis double-angle numerical control universal milling head

A multifunctional display platform of a direct-drive A / C-axis double-angle numerical control universal milling head comprises a pedestal, a stand column and a head body, wherein the pedestal is welded; the stand column is a hollow pipe, and the lower end of the stand column is connected with the pedestal through a bolt while the upper end thereof is abutted with the head body through axle hole clearance fit; a wire groove communicated with the inner hole of the stand column is arranged on the pedestal corresponding to the mounting position of the stand column; a rectangular groove is arrangedat the side of the pedestal; and the head body is a hollow welded cubic structure or a regular trigone column assembled by a welding bracket, a protection piece and a connection piece. The multifunctional display platform of the direct-drive A / C-axis double-angle numerical control universal milling head has the following advantages of: (1) replacing the machine tool, independently displaying the functions of the functional components, and saving the cost; (2) being convenient for assembly and transportation because the stand column and the pedestal are fixed through a bolt, and the stand column and the head body are combined through a joint and reducing the time and cost; (3) shortening the development period and reducing the development risk; and (4) occupying small area, wherein three or four multifunctional display platforms of the direct-drive A / C-axis double-angle numerical control universal milling head can be arranged in the area occupied by one machine tool.
Owner:SHENYANG MACHINE TOOLGRP RES & DESIGN INST CO LTD SHANGHAI BRANCH
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