The invention provides a method for quickly screening saccharification and / or
ageing resisting substances. The method comprises the steps of feeding fruit flies of 1-3 days old with a
cane sugar aqueous solution containing potential active substances to be tested, besides, using the fruit flies only fed with a
cane sugar aqueous solution as a control group, then performing hungry treatment on thetwo groups of the fruit flies, finally, performing feeding with pyruvic
aldehyde, and counting the death quantity of the fruit flies at intervals until the two groups of the fruit flies are dead completely; and when the
mortality rate of the fruit flies in the control group is 40%-60%, performing statistics on the survival condition of the fruit flies in the experiment group, judging whether the potential active substances to be tested can prolong the survival time of the fruit flies or not, and if yes, determining that the substances are saccharification and / or
ageing resisting substances. Within a 7-day experiment period, compared with a conventional
cell model and other animal models, at an extremely low economy cost, whether one substance has activity of resisting saccharification andageing can be determined, and a prominent platform is provided for large-scale high-
throughput screening of active substances for resisting diabetes and resisting
ageing relevant diseases.