1results about How to "Reduce R&D Risk" patented technology

This invention relates to a high-throughput prediction method and system for drug-regulatory element associations. The method includes: constructing a regulatory element-transcription factor network; constructing a regulatory element-target gene network; using the expression levels of transcription factors bound to the regulatory element and the target gene of the regulatory element as inputs, constructing a predictive model of the chromatin openness of the regulatory element; using gene expression levels under different drug action conditions as inputs, using the predictive model to predict and compare the openness of the regulatory element under different drug action conditions, thereby predicting drug-regulatory element associations. This invention can predict the relationship between regulatory elements and drugs at the genome-wide level with high throughput, enabling high-throughput screening of drug-regulatory element associations with relatively low investment, reducing drug development risks. These associations have potential value in research on drug mechanisms, drug combinations, and drug repositioning.