Composite vitamin B powdery injection for venous infusion and preparation thereof

A technology of compound vitamins and powder injections, which is applied in the direction of medical preparations containing active ingredients, powder delivery, drug combination, etc. It can solve the problems of poor drug stability, easy oxidation reaction, short storage time, etc.

Inactive Publication Date: 2008-01-16
WUXI KAIFU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The domestic market already has compound vitamin B injections. The oral and aqueous injections of this product are currently on the market. Due to the poor stability of the drug in aqueous solution and easy oxidation reactions, water-soluble injections have the disadvantage of short storage time.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Formula: Vitamin B 1 20g

[0015] Riboflavin Sodium Phosphate 2.74g

[0016] Vitamin B 6 2g

[0017] Niacinamide 30g

[0018] Sodium D-pantothenate 1g

[0019] Edetate Disodium 0.2g

[0020] Low Molecular Dextran 40 20g

[0021] A total of 1000 pieces were made

[0022] The preparation process includes pretreatment: under the condition of 10,000 grades, heat and dissolve the prescribed amount of low-molecular dextran 40 with 50-200ml water for injection, add activated carbon to boil, keep stirring for 20-30 minutes, filter while it is hot, and let the filtrate cool as a pretreatment solution.

[0023] Ingredients: add water for injection to the pretreatment solution to 50-90% of the ingredients, add 0.1-1g of edetate disodium and stir to dissolve, then add the prescribed amount of vitamin B 1 , Vitamin B 6 , Niacinamide and D-pantothenic acid sodium were dissolved in ...

Embodiment 2

[0030] Formula: Vitamin B 1 20g

[0031] Riboflavin Sodium Phosphate 2.74g

[0032] Vitamin B 6 2g

[0033] Niacinamide 30g

[0034] Sodium D-pantothenate 1g

[0035] Edetate Disodium 0.2g

[0036] Mannitol 20g

[0037] A total of 1000 pieces were made

[0038] Preparation process: except that the auxiliary materials added are different, others are the same as in Example 1

Embodiment 3

[0040] Formula: Vitamin B 1 20g

[0041] Riboflavin Sodium Phosphate 2.74g

[0042] Vitamin B 6 2g

[0043] Niacinamide 30g

[0044] Sodium D-pantothenate 1g

[0045] Edetate Disodium 0.2g

[0046] Cyclodextrin 20g

[0047] A total of 1000 pieces were made

[0048] Preparation process: except that the auxiliary materials added are different, others are the same as in Example 1

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PUM

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Abstract

A powder injection of composite VB for intravenous injection is prepared from VB1, riboflavine sodium phosphate, VB6, nicotinic amide, sodium dextropantothenate, edetate disodium, low-molecular dextran and excipient through pretreating, proportional mixing, filtering for removing bacteria, and freeze drying.

Description

technical field [0001] The invention relates to a biologically active compound vitamin B powder injection and a preparation method, belonging to pharmaceutical products. Background technique [0002] Vitamins are one of the six essential nutrients for human growth and health. Since such substances cannot be synthesized in humans and most animals, or the amount of synthesis cannot meet the needs of the body, they must be regularly obtained through food or other methods. ingested from outside. There are more than 20 kinds of vitamins in total, and each vitamin plays a different biochemical function in the living body. They cannot replace each other, and there is no other substitute. Although vitamin requirements are minimal, they play an important role in regulating physiological functions. Vitamins can enhance the functions of the nervous system, blood vessels, muscles and other systems, and participate in the composition of the enzyme system. Most vitamins participate in t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/525A61K9/14A61P3/02A61K31/51A61K31/4415A61K31/197A61K31/455
Inventor 郑静佳欧阳健
Owner WUXI KAIFU PHARMA
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