Use of epothilones in the treatment of brain diseases associated with proliferative processes

An epothilone technology for use in the treatment of primary or secondary brain tumors, multiple sclerosis, and Alzheimer's disease to address issues such as no carcinogenic potential

Inactive Publication Date: 2009-04-01
SCHERING AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It would therefore be desirable to provide compounds effective in the treatment of encephalopathy associated with proliferative processes, which have similar or better BBB penetration properties than nitrosourines, but without their carcinogenic potential

Method used

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  • Use of epothilones in the treatment of brain diseases associated with proliferative processes
  • Use of epothilones in the treatment of brain diseases associated with proliferative processes
  • Use of epothilones in the treatment of brain diseases associated with proliferative processes

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Embodiment Construction

[0047] The term "encephalopathy associated with a proliferative process" in the context of the present invention includes, but is not limited to, primary brain tumors such as astrocytoma, oligodendroglioma, pineal tumor, medulloblastoma , schwannomas, meningiomas and ependymomas, secondary brain tumors, multiple sclerosis and Alzheimer's disease, all these represent preferred encephalopathy associated with proliferative processes to be treated according to the invention.

[0048] Particularly preferred encephalopathy associated with proliferative processes to be treated by administration of epothilones according to the invention are primary and secondary brain tumors.

[0049] The term "therapeutically effective amount" as used herein refers to an amount of a compound of the invention sufficient to be effective in treating encephalopathy associated with a proliferative process as defined below when administered to a subject in need thereof. The amount that constitutes a "thera...

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Abstract

This invention provides the use of an Epothilone, which shows an average distribution coefficient between plasma and brain of 0.3 to 1.5 in the mouse intravenous bolus injection assay, for the preparation of a medicament for the treatment of a brain disease associated with proliferative processes.

Description

technical field [0001] The present invention relates to the use of epothilone in the treatment of encephalopathy related to proliferative process, especially primary or secondary brain tumor, multiple sclerosis and Alzheimer's disease. Background technique [0002] The possibilities for drug treatment of encephalopathy are greatly limited by the presence of the so-called blood-brain barrier (BBB). Although the BBB functions as a protective mechanism against the entry of foreign substances into the brain tissue, it unfortunately also prevents the entry of drugs administered by conventional means (oral, parenteral, etc.) (A. Maelicke, Nachr. Chem Tech. Lab .1989, 37, 32-34). [0003] An important class of brain diseases that are difficult to treat pharmacologically for the reasons mentioned above are those related to proliferative processes, such as brain tumors, multiple sclerosis or Alzheimer's disease. Various studies on these diseases, especially cancer, have provided so...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/428A61K31/423A61K31/4709A61K31/427A61K31/4427A61P25/28A61P35/00C07D401/04A61P25/00C07D401/06C07D413/04C07D417/04C07D417/06C07D493/04
CPCA61K31/4427A61K31/4709A61K31/427A61K31/428A61K31/423A61P25/00A61P25/28A61P35/00A61K31/425
Inventor 罗斯玛丽·利希特纳安德烈亚·罗特盖里乌尔里希·克拉尔延斯·赫夫曼贝恩德·布赫曼沃尔夫冈·施韦德维尔纳·斯库巴尔拉
Owner SCHERING AG
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