Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of epothilones in the treatment of brain diseases associated with proliferative processes

An epothilone technology for use in the treatment of primary or secondary brain tumors, multiple sclerosis, and Alzheimer's disease to address issues such as no carcinogenic potential

Inactive Publication Date: 2009-04-01
SCHERING AG
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It would therefore be desirable to provide compounds effective in the treatment of encephalopathy associated with proliferative processes, which have similar or better BBB penetration properties than nitrosourines, but without their carcinogenic potential

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of epothilones in the treatment of brain diseases associated with proliferative processes
  • Use of epothilones in the treatment of brain diseases associated with proliferative processes
  • Use of epothilones in the treatment of brain diseases associated with proliferative processes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0047] The term "encephalopathy associated with a proliferative process" in the context of the present invention includes, but is not limited to, primary brain tumors such as astrocytoma, oligodendroglioma, pineal tumor, medulloblastoma , schwannomas, meningiomas and ependymomas, secondary brain tumors, multiple sclerosis and Alzheimer's disease, all these represent preferred encephalopathy associated with proliferative processes to be treated according to the invention.

[0048] Particularly preferred encephalopathy associated with proliferative processes to be treated by administration of epothilones according to the invention are primary and secondary brain tumors.

[0049] The term "therapeutically effective amount" as used herein refers to an amount of a compound of the invention sufficient to be effective in treating encephalopathy associated with a proliferative process as defined below when administered to a subject in need thereof. The amount that constitutes a "thera...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

This invention provides the use of an Epothilone, which shows an average distribution coefficient between plasma and brain of 0.3 to 1.5 in the mouse intravenous bolus injection assay, for the preparation of a medicament for the treatment of a brain disease associated with proliferative processes.

Description

technical field [0001] The present invention relates to the use of epothilone in the treatment of encephalopathy related to proliferative process, especially primary or secondary brain tumor, multiple sclerosis and Alzheimer's disease. Background technique [0002] The possibilities for drug treatment of encephalopathy are greatly limited by the presence of the so-called blood-brain barrier (BBB). Although the BBB functions as a protective mechanism against the entry of foreign substances into the brain tissue, it unfortunately also prevents the entry of drugs administered by conventional means (oral, parenteral, etc.) (A. Maelicke, Nachr. Chem Tech. Lab .1989, 37, 32-34). [0003] An important class of brain diseases that are difficult to treat pharmacologically for the reasons mentioned above are those related to proliferative processes, such as brain tumors, multiple sclerosis or Alzheimer's disease. Various studies on these diseases, especially cancer, have provided so...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/428A61K31/423A61K31/4709A61K31/427A61K31/4427A61P25/28A61P35/00C07D401/04A61P25/00C07D401/06C07D413/04C07D417/04C07D417/06C07D493/04
CPCA61K31/4427A61K31/4709A61K31/427A61K31/428A61K31/423A61P25/00A61P25/28A61P35/00A61K31/425
Inventor 罗斯玛丽·利希特纳安德烈亚·罗特盖里乌尔里希·克拉尔延斯·赫夫曼贝恩德·布赫曼沃尔夫冈·施韦德维尔纳·斯库巴尔拉
Owner SCHERING AG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com