Use of epothilones in the treatment of brain diseases associated with proliferative processes

An epothilone technology for use in the treatment of primary or secondary brain tumors, multiple sclerosis, and Alzheimer's disease to address issues such as no carcinogenic potential
CN100473381CInactive Publication Date: 2009-04-01SCHERING AG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SCHERING AG
Publication Date
2009-04-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides the use of an Epothilone, which shows an average distribution coefficient between plasma and brain of 0.3 to 1.5 in the mouse intravenous bolus injection assay, for the preparation of a medicament for the treatment of a brain disease associated with proliferative processes.
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Description

technical field

[0001] The present invention relates to the use of epothilone in the treatment of encephalopathy related to proliferative process, especially primary or secondary brain tumor, multiple sclerosis and Alzheimer's disease. Background technique

[0002] The possibilities for drug treatment of encephalopathy are greatly limited by the presence of the so-called blood-brain barrier (BBB). Although the BBB functions as a protective mechanism against the entry of foreign substances into the brain tissue, it unfortunately also prevents the entry of drugs administered by conventional means (oral, parenteral, etc.) (A. Maelicke, Nachr. Chem Tech. Lab .1989, 37, 32-34).

[0003] An important class of brain diseases that are difficult to treat pharmacologically for the reasons mentioned above are those related to proliferative processes, such as brain tumors, multiple sclerosis or Alzheimer's disease. Various studies on these diseases, especially cancer, have provided so...

Claims

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