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Drop pills of medical broth of small bupleurum root

A technology of decoction dripping pills and Bupleurum bupleurum, applied in the field of traditional Chinese medicine preparations and its preparation, can solve the problems of low natural degree, low natural degree, and low natural degree of dripping pill auxiliary materials, achieve reduction of drug irritating smell, improve Oral pH, high natural effect

Inactive Publication Date: 2009-12-02
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] With the global expansion of the market and the requirement of human beings to return to nature, the use of drugs with low toxicity and side effects, especially pure natural drugs, has become the first choice of people. The dropping pill preparation is a new type of Chinese medicine preparation with high efficiency and quick effect. The shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the current drop pill preparations generally face the following problems: 1. The drop pill auxiliary materials are not purely natural: at present, most of the drop pill base auxiliary materials are chemically synthesized, and the natural degree is low. New alternatives The search for matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, is also very difficult, because the preparation conditions required for common and possible substitutes for natural matrix excipients are very harsh. And its dripping pill dripping conditions are the key to affect the preparation of dripping pills
If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work
2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market, and has become a stumbling block for Chin

Method used

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  • Drop pills of medical broth of small bupleurum root
  • Drop pills of medical broth of small bupleurum root
  • Drop pills of medical broth of small bupleurum root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] (a) Take 33.3g of Bupleurum, 166.7g of Pinellia chinensis, 166.7g of Scutellaria baicalensis, 166.7g of Codonopsis pilosula, 166.7g of jujube, 111.1g of licorice, 88.9g of ginger, 65.5g of xylitol, and 18.5g of gum arabic;

[0076](b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation liquid to obtain concentrated solution (2), set aside, take Codonopsis pilosula, jujube and l...

Embodiment 2

[0079] (a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Chinese jujube 166.7g, licorice 111.1g, ginger 88.9g, xylitol, and gum arabic;

[0080] (b) Take Radix Bupleurum, add water to distill and extract once for 3 hours to obtain volatile oil and water decoction, add water to extract the remaining medicinal dregs once for 1 hour, and combine with the water decoction obtained from the initial distillation , properly concentrated to a relative density of 1.10 at 50°C, let cool, add ethanol to precipitate until the alcohol content reaches 50%, let it stand, take the supernatant to concentrate and recover the ethanol to obtain a concentrated solution, and set aside; take pinellia and ginger, add 50 % of ethanol percolation, concentrate percolation liquid to obtain concentrated liquid, set aside; take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to a rel...

Embodiment 3

[0083] (a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Chinese jujube 166.7g, licorice 111.1g, ginger 88.9g, lactitol, and starch for later use;

[0084] (b) Take Radix Bupleurum, add water to distill and extract 2 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1.5 hours, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.30 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 50%, left to stand, and the supernatant was concentrated to recover the ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 60% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract ...

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Abstract

The invention provides a medicine for treating alternating cold and heat, bitter fullness in the chest and sides, upset and vomiting, bitter mouth and dry throat. In the food additive catalogs of some countries, the shortcomings of dropping pills with poor taste are a kind of pharmaceutical preparation with higher natural degree, stronger safety and lower toxic and side effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof. Specifically, the invention relates to a Xiaochaihutang dripping pill, and the invention also discloses a preparation method thereof. Background technique [0002] Xiao Chaihu Decoction comes from Zhang Zhongjing's "Treatise on Febrile Diseases", consisting of Bupleurum, Scutellaria, Ginseng, Pinellia, Licorice, Ginger, and Jujube. The original book is used to treat typhoid shaoyang syndrome and the symptoms caused by it: as well as jaundice and other shaoyang syndromes. In long-term medical practice, this prescription is widely used in the treatment of liver and gallbladder, digestion, endocrine, blood, immune and other system diseases . [0003] As a common synthetic chemical substance commonly used in modern medicine, it has pervaded every corner of human life. Chemical synthetic drugs have become the mainstream of medicine. Reality and the latest...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K36/9068A61K36/8888A61K36/725A61K36/539A61K36/484A61K36/344A61K36/233A61P1/16A61P1/00
Inventor 童玉新李清华谢卫锋高玉珍陈莉琳叶正良祝国光朱永宏陈建明郑永锋李旭李永强章顺楠刘金平魏峰范立君
Owner TIANJIN TASLY PHARMA CO LTD
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