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Preparing method of biliary-tract carriage carrying about medicine

A technology for internal stents and biliary tracts, which is applied in the field of preparation of biliary internal stents carrying drugs, which can solve the problems of uneven and difficult mixing of drugs and excipients, and achieve the effects of proper methods, accurate medication, and simple operations

Inactive Publication Date: 2010-09-15
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the current situation that medical devices are mainly produced and provided by medical device manufacturers, and doctors only use medical devices directly, they want to obtain "according to different conditions, according to different drug release time requirements, and different drug dosages. store different drugs" effect, it is quite difficult
As far as the biliary stent carrying the drug is concerned, this not only requires the medical device manufacturer to master quite a lot of drug formulas, proportions and preparation methods, but also can only carry out single-piece production in the process of industrialized mass production. The bigger problem is that this kind of workshop production often also causes the problem of uneven mixing of drugs and excipients stored in the drug storage layer of the biliary stent
The crux of the problem is that there is still a lack of a method that can prepare corresponding drug-carrying biliary stents according to the requirements of different diseases and different etiologies.

Method used

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  • Preparing method of biliary-tract carriage carrying about medicine
  • Preparing method of biliary-tract carriage carrying about medicine
  • Preparing method of biliary-tract carriage carrying about medicine

Examples

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Embodiment Construction

[0020] A kind of preparation method of the biliary inner stent that carries medicine (refer to figure 1 , 2 , 4, 6, 7). The biliary internal stent used in the method includes a tubular support tube 2 capable of opening the lumen of the bile duct and having several drug release holes 21 . On the inner wall of the tubular support tube 2, there is a drug storage layer 3 mixed with drugs and excipients. The core of the drug storage layer 3 has a drainage hole 10 for the conduction of the bile duct; the two ends of the tubular support tube 2 There are matching connectors respectively, allowing two or more biliary stents to be connected in series.

[0021] Obviously, the matching of the connector can have multiple structural forms, for example, the connectors at both ends are respectively a section of internal thread 23 and a section of external thread 13 (refer to Figure 6 , Figure 8 ), or the connectors at both ends are respectively a circle of ring-shaped inner buckle 23' a...

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Abstract

The present invention relates to a biliary tract interior support frame containing medicine and its preparation method. Said biliary tract interior support frame includes tubular supporting tube which can open cavitary tract of biliary duct and is equipped with several medicine-releasing holes. The inner wall of the invented tubular supporting tube has a layer of medicine-stored layer made up by mixing medicine and excipient. Several biliary tract interior suppert frames can be series-connected together. Said invention also provides the concrete steps of its preparation method.

Description

technical field [0001] The invention relates to a stent implantable in the biliary tract of a human body, in particular to a method capable of preparing a biliary stent carrying medicine. Background technique [0002] Malignant obstruction of the biliary tract is mostly caused by compression of the hepatic and bile ducts by primary cholangiocarcinoma, liver cancer, pancreatic head cancer, ampulla cancer, gallbladder cancer and other metastatic cancers. Biliary stents relieve symptoms caused by strictures or blockages by dilating narrowed bile ducts or clearing blocked ones. However, stent implantation also has some shortcomings, such as restenosis after implantation is still a clinical problem, the restenosis rate is 13.8%, and a series of symptoms of obstructive jaundice appear after stenosis. Studies on the etiology of stent restenosis have shown that the causes of stent restenosis include tumor growth, tissue reaction hyperplasia, and biliary sludge formation. It has be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/82A61L29/00A61M31/00A61M29/00A61K45/00
Inventor 刘耀刘松青
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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