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Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder

一种胃泌素释放肽、炎性疾病的技术，应用在脓毒症和急性肺损伤,双相性精神障碍领域

Inactive Publication Date: 2007-12-19
CRISTALIA PROD QUI FARM LTDA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, without proper treatment, hypomanic patients may turn into severe mania or depression

Method used

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  • Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
  • Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
  • Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder

Examples

Experimental program
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Embodiment

[0108] I)

[0109] Here, the inventors of the present invention demonstrate the therapeutic potential of the bombesin / GRP antagonist RC-3095 for the treatment of the inflammatory disease rheumatoid arthritis.

[0110] They further demonstrated the therapeutic potential of the bombesin / GRP antagonist RC-3095 for the treatment of two inflammatory diseases, sepsis and acute lung injury. Experiments on the effect of RC-3095 on macrophages revealed that RC-3095 impairs the release of pro-inflammatory cytokines TNF-α and IL-1β by activated macrophages.

[0111] In a well-established model of experimental sepsis, treatment with the bombesin / GRP receptor antagonist RC-3095 attenuated TNF-α and Serum levels of IL-1β and increase survival in inflammatory diseases, especially in "established" sepsis. Furthermore, the bombesin / GRP antagonist RC-3095 was found to reduce lung injury induced by intratracheal instillation of lipopolysaccharide (LPS) in an established acute lung injury (ALI)...

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Abstract

The present invention relates to the use of bombesin / gastrin releasing peptide antagonist in the preparation of pharmaceutical composition, said pharmaceutical composition is used for treating inflammatory diseases and immune-mediated inflammatory diseases, especially sepsis , acute lung injury and rheumatoid arthritis and for the treatment or prevention of brain disorders, preferably bipolar disorders, and in particular of different types and / or subtypes of bipolar disorders such as mania, acute mania, Severe mania, hypomania, depression, moderate depression, dysthymia, major depressive disorder, manic and / or depressive episodes, psychotic / psychotic symptoms (e.g., hallucinations, delusions), mixed bipolar states, Bipolar I disorder, bipolar II disorder, and / or rapid cycling bipolar disorder. In particular, specific nonapeptides with antagonist properties against bombesin or bombesin-like peptides such as gastrin-releasing peptide can be used in the treatment of inflammatory and immune-mediated inflammatory diseases and brain disorders .

Description

field of invention [0001] The present invention relates to novel therapeutic strategies for the treatment of inflammatory and immune-mediated inflammatory diseases, particularly sepsis and acute lung injury, by administering bombesin / gastrin releasing peptide antagonists, and Bipolar disorder. Background of the invention [0002] The bombesin / gastrin-releasing peptide (GRP) receptor system (ie, bombesin / gastrin, their receptors and components of receptor-mediated signaling pathways) is known to be involved in several aspects of the CNS Regulation of function (Yamada et al., Mol. Psychiatry 7, 113-117 (2002)), involvement in neuropsychiatric disorders such as schizophrenia (Mellar et al., Peptides 25, 585-588 (2004)) and autism (Ishikawa-Brush et al. , Hum.Mol.Genet.6, 1241-1250 (1997)), involved in the development of cancer (Schwarts-mann, G., Lung Cancer 46, 129 (2004); Szepeshazi et al., Proc.Natl.Acad.Sci.U.S.A.94 , 10913 (1997)), and involvement in the pathogenesis of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/04A61P1/00A61P7/00A61P11/00A61P19/02A61P25/18A61P25/24A61P29/00A61K38/08
CPCA61K38/08A61K38/105A61K38/2207A61P1/00A61P1/04A61P11/00A61P19/02A61P25/00A61P25/08A61P25/18A61P25/20A61P25/24A61P29/00A61P31/04A61P35/00A61P37/02A61P43/00A61P7/00
Inventor G·施瓦特曼R·勒斯勒尔F·戴尔皮佐尔J·L·克韦多F·考普钦斯基
Owner CRISTALIA PROD QUI FARM LTDA
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