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New application of dendrobine

A technology of dendrobine and medicine, which is applied in the new application field of dendrobine, and can solve the problems of undefined pharmacological active ingredients, unclear material basis of pharmacological effects, complex components, etc.

Inactive Publication Date: 2008-01-16
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the complex composition of the above-mentioned Dendrobium nobile extract, which contains a variety of alkaloids and other chemical components, the material basis of its medicinal effect is not clear, that is, the active ingredient of the pharmacological action is not clear.

Method used

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  • New application of dendrobine

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Embodiment 1

[0011] The extraction and separation of embodiment 1 formula I compound dendrobine

[0012] According to the above literature (T.Okamoto, et al.The structure of dendrobine.Chem.Pharm.Bull., 1964,12(4):506-512; Y.Inubushi, et al.Isolation and Characterization of Alkaloids of the Chinese Drug " Chin-Shih-Hu ".Chem.Pharm.Bull., 1964,12 (10): 1175-1180) the method in carries out extraction and separation, and concrete steps are as follows:

[0013] The commercially available 1.0kg Dendrobium nobile medicinal material was chopped and soaked in 8L of methanol for two days, filtered, and the residue was reflux extracted with methanol for 4 times (5L each time), and the extracts were combined and concentrated under reduced pressure to obtain a thick extract. % hydrochloric acid aqueous solution was dissolved and extracted several times, filtered, combined the acidic water extracts, added ammonia water in an ice bath to adjust the pH to about 11.0, the alkaline aqueous solution was ext...

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Abstract

The invention discloses two novel purposes of dendrobine, namely applications in preparation of drug for preventing or treating arthritis and protecting gastrointestinal mucosa from lesion.

Description

technical field [0001] The present invention relates to a new application of dendrobine, especially the application in the prevention or treatment of arthritis and the protection of digestive tract mucosal damage. Background technique [0002] Dendrobine (Dendrobine), as a chemical component, was first isolated from the Chinese medicinal material Dendrobium nobile Lindl. in 1932 (H.Suzuki, et al.: YakugakuZasshi, 52, 996, 1049 (1932); 54, 801(1934).), in 1962, its extraction and separation method was clarified, and its complete chemical structure was confirmed (T.Okamoto, et al.The structure of dendrobine.Chem.Pharm.Bull., 1964, 12(4):506 -512; Y.Inubushi, et al.Isolation and Characterization of Alkaloids of the Chinese Drug "Chin-Shih-Hu". Chem.Pharm.Bull., 1964, 12 (10): 1175-1180), its chemical structure is as follows As shown in I, the molecular formula is C 16 h 25 NO 2 , with a molecular weight of 263. [0003] [0004] According to the retrieval of existing li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61P1/04A61P19/02
Inventor 华茉莉刘全海庄贤韩戴静芝沈龙海卢艳萍李定祥刘珉宇李晶晶王小晨
Owner SHANGHAI INST OF PHARMA IND CO LTD
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